Evaluation of the quality of life in oncology patients after total temporomandibular joint replacement using a new domestic system

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Introduction. Treatment of primary and secondary neoplastic lesions of the temporomandibular joint (TMJ) remains a highly relevant problem. These tumors are characterized by a variety of histological types, a lack of pathognomonic symptoms, and the complexity of their location. Surgical treatment typically involves extended mandibular resections with TMJ exarticulation and removal of the infratemporal fossa structures. The mandible and TMJ form an anatomic and functional complex that ensures mastication, deglutition, and speech production. Disruption of the mandibular arch continuity and the absence of the TMJ lead to persistent impairment of all the aforementioned functions, which significantly decreases the patients’ quality of life. In this regard, the development of effective methods for mandibular reconstruction with immediate or delayed total TMJ replacement aimed at restoring the lost functions is a relevant scientific and practical task.

Aim. To evaluate the quality of life in patients after extended combined oral cavity resections with immediate or delayed total TMJ replacement.

Materials and methods. The study included 17 patients with head and neck tumors involving the TMJ structures who were examined and underwent surgical treatment between 2020 and 2025 at the N. N. Blokhin National Medical Research Center of Oncology (Moscow) and the Clinical Hospital “Lapino” (Moscow Region). In all cases, segmental resection of the mandible with TMJ exarticulation and immediate or delayed total replacement of this joint was performed, and a total TMJ replacement system manufactured by LLC “LOGIX Medical Systems” (Novosibirsk, Russia) was placed. All patients completed the University of Washington Quality of Life (UW-QOL) v4 questionnaire for head and neck cancer patients 7 days prior to surgery and 3 months postoperatively.

Results. According to the UW-QOL v4 questionnaire, a positive trend in the patients’ quality of life was observed across most domains after surgical treatment. In the preoperative period, the majority of patients exhibited severe impairment of physical functions and psycho-emotional status indicators. Three months after total TMJ replacement, quality of life indicators improved significantly, demonstrating the efficacy of the utilized joint replacement system.

Conclusion. In primary and secondary tumor lesions of the TMJ after exarticulation, total joint replacement is the method of choice, ensuring the restoration of lost functions and improving the patients’ quality of life.

About the authors

Artur A. Marienko

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

Author for correspondence.
Email: arturmarienko1@gmail.com
ORCID iD: 0000-0001-6679-2432
Russian Federation, 111 1st Uspenskoe Shosse, Lapino, Moscow Region 143081

A. M. Mudunov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies; Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: arturmarienko1@gmail.com
ORCID iD: 0000-0002-0918-3857
Russian Federation, 111 1st Uspenskoe Shosse, Lapino, Moscow Region 143081; Bld. 2, 8 Trubetskaya St., Moscow 119048

M. V. Bolotin

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies, Federal Medical and Biological Agency of Russia

Email: arturmarienko1@gmail.com
ORCID iD: 0000-0001-7534-6565
Russian Federation, 28 Orekhovy Boulevard, Moscow 115682

References

  1. Sha J. Surgery of tumors of the head and neck: translated from English. Ed.: I.V. Reshetov. Moscow: 2023. P. 1. (In Russ.).
  2. Reconstructive surgery for tumors of the head and neck. Ed.: E.G. Matyakin, Moscow, 2009, p. 169. (In Russ.).
  3. Azizyan R.I. Combined reconstructive surgery for head and neck tumors. Dis. ... Doctor of Medical Sciences, Moscow, 1997. (In Russ.).
  4. Ivanov V.M. Reconstructive plastic surgery for locally advanced cancer of the oropharyngeal region. Dis. ... Doctor of Medical Sciences, Moscow, 2002. (In Russ.).
  5. Lyubaev V.L. Surgical method in the treatment of locally advanced cancer of the oral mucosa and oropharynx. Dis. ... Doctor of Medical Sciences, Moscow, 1985. (In Russ.).
  6. Falileev G.V., Nerobeev A.I., Nummaev G.M., Matyakin E.G. Indications for primary and delayed plastic surgery of pharyngeal and cervical esophageal defects after their removal for advanced cancer: method. recommendations. Moscow, 1986. (In Russ.).
  7. Kropotov M.A. Reconstructive operations on the lower jaw in patients with cancer of the oral mucosa. Vestnik RONTC im. N.N. Blohina RAMN = Jornal of N.N. Blokhin Russian Research Center RAMS 2003;2:50–7. (In Russ.).
  8. Singh S., Wang Z., George R. et al. Benign and malignant neoplasms in temporomandibular joint (TMJ): a narrative review. J Maxillofac Anestesia 2025;4. doi: 10.21037/joma-24-25
  9. Hinton R.J., Jing J., Feng J.Q. Genetic influences on temporomandibular joint development and growth. Curr Top Dev Biol 2015;115:85–109. doi: 10.1016/bs.ctdb.2015.07.008
  10. Semkin V.A., Rabukhina N.A., Volkov S.I. Pathology of the temporomandibular joints. Moscow: Practicheskaya meditsina, 2011. 168 p. P. 24. (In Russ.).
  11. Yibulayin F., Yu C.X., Feng L. et al. Malignant tumours of temporomandibular joint. BMC Cancer 2020;20(1):967. doi: 10.1186/s12885-020-07425-9
  12. Ren R., Mueller S., Kraft A.O., Powers C.N. Giant cell tumor of temporomandibular joint presenting as a parotid tumor: challenges in the accurate subclassification of giant cell tumors in an unusual location. Diagn Cytopathol 2018;46(4):340–4. doi: 10.1002/dc.23848
  13. Gonzalez-Perez L.M., Montes-Carmona J.F., Torres-Carranza E., Infante-Cossio P. Total joint replacement for immediate reconstruction following ablative surgery for primary tumors of the temporo-mandibular joint. J Pers Med 2023;13(7):1021. doi: 10.3390/jpm13071021
  14. Choi J.H., Ro J.Y. The 2020 WHO classification of tumors of bone. Adv Anat Pathol 2021;28(3):119–38. doi: 10.1097/PAP.0000000000000293
  15. Al Hayek M., Yousfan A. Monophasic synovial sarcoma in the temporomandibular joint region: a case report and review of the literature. Int J Surg Case Rep 2023;105:107998. doi: 10.1016/j.ijscr.2023.107998
  16. Gerbino G., Segura-Pallarès I., Ramieri G. Osteochondroma of the mandibular condyle. J Craniomaxillofac Surg 2021;4997):584–91. doi: 10.1016/j.jcms.2021.04.007
  17. Holmlund A.B., Gynther G.W., Reinholt F.P. Surgical treatment of osteochondroma of the mandibular condyle. Int J Oral Maxillofac Surg 2004;33(6):549–53. doi: 10.1016/j.ijom.2004.01.006
  18. Gonzalez-Perez L.M., Sánchez-Gallego F., Pérez-Ceballos J.L., López-Vaquero D. Temporomandibular joint chondrosarcoma. J Craniomaxillofac Surg 2011;39(1):79–83. doi: 10.1016/j.jcms.2010.03.018
  19. Yu H.B., Sun H., Li B. et al. Endoscope-assisted conservative condylectomy. Int J Oral Maxillofac Surg 2013;42(12):1582–6. doi: 10.1016/j.ijom.2013.05.002
  20. Ord R.A., Warburton G., Caccamese J.F. Osteochondroma of the condyle: review of 8 cases. Int J Oral Maxillofac Surg 2010;39(6):523–8. doi: 10.1016/j.ijom.2010.02.015
  21. Poveda-Roda R., Bagán J.V., Sanchis J.M., Margaix M. Pseudotumors and tumors of the temporomandibular joint: a review. Med Oral Patol Oral Cir Bucal 2013;18(3):392–402. doi: 10.4317/medoral.18799
  22. Faro T.F., Martins-de-Barros A.V., Lima G.T.W.F. et al. Chondrosarcoma of the temporomandibular joint: Systematic review and survival analysis. Head Neck Pathol 2021;15(3):923–34. doi: 10.1007/s12105-021-01313-9
  23. Bredell M., Grätz K., Obwegeser J., Gujer A.K. Management of the temporomandibular joint after ablative surgery. Craniomaxillofac Trauma Reconstr 2014;7(4):271–9. doi: 10.1055/s-0034-1378181
  24. Park J.H., Jo E., Cho H., Kim H.J. Temporomandibular joint reconstruction with alloplastic prosthesis. Maxillofac Plastic Reconst Surg 2017;39(1):6. doi: 10.1186/s40902-017-0103-7
  25. Morey-Mas M.A., Caubet-Biayna J., Iriarte-Ortabe J.I. Osteochondroma of the temporomandibular joint treated by condylectomy and immediate reconstruction with a total stock prosthesis. J Oral Maxillofac Res 2010;1(4):e4. doi: 10.5037/jomr.2010.1404
  26. Kumar V.V. Large osteochondroma of the mandibular condyle treated by condylectomy using a transzygomatic approach. Int J Oral Maxillofac Surg 2010;39(2):188–91. doi: 10.1016/j.ijom.2009.12.004
  27. Ruiz Valero C.A., Duran-Rodriguez G., Solano-Parra N., Castro-Núñez J. Immediate total temporomandibular joint replacement with temporomandibular joint concepts prosthesis as an alternative for ameloblastoma cases. J Oral Maxillofac Surg 2014;72(3): 646.e1–12. doi: 10.1016/j.joms.2013.09.026
  28. Anderson S.R., Pak K.Y., Vincent A.G. et al. Reconstruction of the mandibular condyle. Facial Plast Surg 2021;37(6):728–34. doi: 10.1055/s-0041-1726444
  29. De Casso C., Kwhaja S., Davies S. et al. Effect of temporal bone resection on temporomandibular joint function: a quality of life study. Otolaryngol Head Neck Surg 2010;142(1):85–9. doi: 10.1016/j.otohns.2009.09.029
  30. Kropotov M.A., Sobolevsky V.A., Dikov Yu. and others. Reconstruction of the temporomandibular joint during segmental resection of the mandible with exarticulation for primary and secondary tumors of the mandible. Al’manakh klinicheskoy meditsiny = Almanac of Clinical Medicine 2017;45(6):486–94. (In Russ.). doi: 10.18786/2072-0505-2017-45-6-486-494
  31. Head C., Daniel Alam D., Sercarz J.A. et al. Microvascular flap reconstruction of the mandible. Otolaryngol Head Neck Surg 2003;129(1):48–54. doi: 10.1016/S0194-5998(03)00480-7
  32. Olbrisch C., Santander P., Moser N. et al. Three-dimensional mandibular characteristics in skeletal malocclusion: a cross-sectional study. J Orofac Orthop 2024;85(2):134–45. doi: 10.1007/s00056-022-00419-1

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2026 ABV-Press

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-36990 от  21.07.2009.