Efficacy of camrelizumab in combination with capecitabine and stereotactic radiation therapy in oligoprogressing squamous cell carcinomas

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Abstract

Camrelizumab is a monoclonal antibody against programmed cell death protein 1 (PD-1) which demonstrated clinical efficacy in esophageal squamous cell carcinoma including in combination with 1st line chemotherapy cases of advanced disease. The article describes a clinical case of administration of camrelizumab + capecitabin in combination with local ablative intervention in the form of stereotactic radiation therapy for treatment of oligoprogressing esophageal squamous cell carcinoma. This observation shows clinical advisability of continuing immunomodulating therapy in cases of limited tumor progression with simultaneous local control of the lesions with the highest biological activity.

About the authors

Y. V. Vakhabova

European Medical Center

Author for correspondence.
Email: yuvahabova@emcmos.ru
ORCID iD: 0000-0002-2209-4410
Russian Federation, 35 Shchepkina St., Moscow, 129090

S. Nidal

European Medical Center

Email: yuvahabova@emcmos.ru
ORCID iD: 0000-0003-2630-4961
Russian Federation, 35 Shchepkina St., Moscow, 129090

P. V. Koposov

European Medical Center

Email: yuvahabova@emcmos.ru
ORCID iD: 0000-0001-8789-9271
Russian Federation, 35 Shchepkina St., Moscow, 129090

E. R. Moskalets

European Medical Center

Email: yuvahabova@emcmos.ru
ORCID iD: 0000-0002-0164-2422
Russian Federation, 35 Shchepkina St., Moscow, 129090

I. E. Loiko

European Medical Center

Email: yuvahabova@emcmos.ru
ORCID iD: 0000-0002-6909-8558
Russian Federation, 35 Shchepkina St., Moscow, 129090

References

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  4. Zhou R.Q., Luo J., Li L.J. et al. Neoadjuvant camrelizumab plus chemotherapy in locally advanced oesophageal squamous cell carcinoma: a retrospective cohort study. BMC Surg 2023;23:114. doi: 10.1186/s12893-023-02023-5
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