Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press11110.17650/2222-1468-2014-0-4-28-33LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫPROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEWПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ БИОМАРКЕРОВ ПРИ ПЛОСКОКЛЕТОЧНОМ РАКЕ ПОЛОСТИ РТА. ОБЗОР ЛИТЕРАТУРЫIgnatovaA. V.ИгнатоваА. В.
Russian Federation

Department of Oncology

Контакты: Анастасия Валерьевна Игнатова annasurge@gmail.com

Кафедра онкологии ГБОУ ДПО РМАПО Минздрава России; 125993, Россия, Москва, ул. Баррикадная, 2/1;

 

annasurge@gmail.comMudunovA. M.МудуновА. М.
Russian Federation
annasurge@gmail.comNarimanovM. N.НаримановМ. Н.
Russian Federation
annasurge@gmail.comRussian Medical Academy of Post-Graduate Education., MoscowФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваResearch Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, MoscowНИИ клинической онкологии ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва150420144428331904201519042015Copyright ©; 2014, Ignatova A.V., Mudunov A.M., Narimanov M.N.Copyright ©; 2014, Игнатова А.В., Мудунов А.М., Нариманов М.Н.2014Ignatova A.V., Mudunov A.M., Narimanov M.N.Игнатова А.В., Мудунов А.М., Нариманов М.Н.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/111

Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of molecules-biomarkers that can be used for prediction of behaviour of this disease to achieve the above objective.

We identified and classified 24 molecular biomarkers into five groups based on their biological functions: 1) cell cycle acceleration and proliferation; 2) hypoxia-inducible factors; 3) tumour suppression and apoptosis; 4) angiogenesis; 5) cell adhesion and matrix degradation. We considered articles published in PubMed-indexed journals over the past 8 years and conducted a literature review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome.

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