Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press16810.17650/2222-1468-2015-5-3-24-30DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИCryosurgical and cryoradiation treatments in patients with calvarial skin cancerКриохирургическое и криолучевое лечение больных раком кожи свода черепаPustynskiyI. N.ПустынскийИ. Н.
Russian Federation
inpustynskiy@yandex.ruTkachevS. I.ТкачёвС. И.
Russian Federation
TabolinovskayaT. D.ТаболиновскаяТ. Д.
Russian Federation
AlievaS. B.АлиеваС. Б.
Russian Federation
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «РОНЦ им. Н. Н. Блохина» Минздрава России23 Kashirskoe Shosse, Moscow, 115478, RussiaРоссия, 115478, Москва, Каширское шоссе, 23241120155324302411201524112015Copyright ©; 2015, Pustynskiy I.N., Tkachev S.I., Tabolinovskaya T.D., Alieva S.B.Copyright ©; 2015, Пустынский И.Н., Ткачёв С.И., Таболиновская Т.Д., Алиева С.Б.2015Pustynskiy I.N., Tkachev S.I., Tabolinovskaya T.D., Alieva S.B.Пустынский И.Н., Ткачёв С.И., Таболиновская Т.Д., Алиева С.Б.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/168

The authors developed a novel cryoradiation treatment in patients with locally advanced basal cell and squamous cell carcinoma of the head skin, which included a combination of tumor cryogenic and radiation exposures. of a tumor. Immediately before each radiotherapy session, local tumor cooling is carried out until the freezing temperature is achieved at the tumor-intact tissue border. Irradiation is performed in cycles: at a single daily focal dose of 2.0–2.5 Gy during 5 days at a 2-day interval until the cumulative focal dose of 60–70 Gy is achieved. The results of cryosurgical and cryoradiation treatments were investigated in 112 patients with basal cell (n = 101) and squamous cell (n = 11) carcinoma of the calvarial skin. Among the patients, there were 48 (42.9 %) men and 64 (57.1 %) women; their mean age was 67.1 (39–107) years. The skin tumor was located in the parietal region in 30 (26.8 %) patients, in the temporal region in 55 (49.1 %), in the frontal region in 26 (23.2 %), and in occipital region in 1. The size of the neoplasms in all the patients was more than 1 cm; the tumors belonged to a high recurrence risk group. The method of treatment was chosen according to indicators. The postoperative follow-ups of the patients were 2 to 14 years (median follow-up, 7 years). Recurrences of skin cancer were diagnosed in 5 (4.5 %) of the 18 patients: 1 (1 %) after treatment for its primary forms and 4 (22.2 %) after that of recurrences. Cryosurgical and cryoradiation treatments performed as clinically indicated could yield good functional, aesthetic, and long-term results and ensure effective rehabilitation in patients after the treatment conducted.

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