Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press18110.17650/2222-1468-2015-5-4-16-27DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИAnalysis of the impact of radiotherapy on long-term treatment results in patients with malignant salivary gland tumorsАнализ влияния эффективности лучевой терапии на отдаленные результаты лечения больных злокачественными опухолями слюнных железVayradyanV. T.ВайрадянВ. Т.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

v_violetta@list.ruMudunovA. M.МудуновА. М.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

AzizyanR. I.АзизянР. И.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

ZaderenkoI. A.ЗадеренкоИ. А.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

AlievaS. B.АлиеваС. Б.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

RuruaN. V.РуруаН. В.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

Kondrat’evaT. T.КондратьеваТ. Т.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

ErmilovaV. D.ЕрмиловаВ. Д.
Russian Federation

23 Kashirskoe Shosse, Moscow, 115478

115478, Москва, Каширское шоссе, 23

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России301220155416271601201616012016Copyright ©; 2015, Vayradyan V.T., Mudunov A.M., Azizyan R.I., Zaderenko I.A., Alieva S.B., Rurua N.V., Kondrat’eva T.T., Ermilova V.D.Copyright ©; 2015, Вайрадян В.Т., Мудунов А.М., Азизян Р.И., Задеренко И.А., Алиева С.Б., Руруа Н.В., Кондратьева Т.Т., Ермилова В.Д.2015Vayradyan V.T., Mudunov A.M., Azizyan R.I., Zaderenko I.A., Alieva S.B., Rurua N.V., Kondrat’eva T.T., Ermilova V.D.Вайрадян В.Т., Мудунов А.М., Азизян Р.И., Задеренко И.А., Алиева С.Б., Руруа Н.В., Кондратьева Т.Т., Ермилова В.Д.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/181

Objective: to investigate the efficiency of radiotherapy for malignant salivary gland tumors and to reveal prognostic factors influencing overall and relapse-free survival rates in this patient group.

Materials and methods. The retrospective and prospective data of 111 patients with malignant salivary gland tumors were analyzed. All the examinees received preoperative radiotherapy to the primary focus and, if need be, regional metastatic areas; the cumulative focal dose was 40–65 (56.0 ± 8.9) Gy. In the following step, the patients were surgically treated. They were divided into 2 groups according to the degree of therapeutic pathomorphism: 1) Degree 0–III (91.9 %) and 2) Degree IV (8.1 %).

Results. Five- and ten-year overall survival rates were 60.1 ± 5.1 and 50.4 ± 5.7 % and 7.5 ± 11,69 and 87.5 ± 11.69 % (unachieved median) in Groups 1 and 2, respectively (p = 0.04); relapse-free survival rates were 53.6 ± 5.1 and 41.33 ± 5.5 % in Group 1 and 88.8 ± 10.4 and 88.8 ± 10.4 % in Group 2 (unachieved median) (р = 0.015). Cox multivariate regression analysis showed that the significant independent signs for overall survival were the pathomorphological characteristics of a tumor (risk ratio (RR) = 1.933; p = 0.010), process location (RR = 0.705; р = 0.010), and tumor grade (RR = 1.825; р = 0.010); those for relapse-free survival were the pathomorphological characteristics of a tumor (RR = 2.177; р = 0.001), regional lymph node metastases (RR = 1.543; р = 0.013), tumor localization (RR = 0.700; р = 0.014), effect of radiotherapy (RR = 1.767; р = 0.042), and tumor grade (RR = 1.754; р = 0.005).

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