Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press2010.17650/2222-1468-2013-0-4-10-14REVIEWSОБЗОРНЫЕ СТАТЬИECTOPIC THYROID: REVIEW OF THE LITERATURE AND ANALYSIS OF THE CLINICAL OBSERVATIONЭКТОПИРОВАННАЯ ЩИТОВИДНАЯ ЖЕЛЕЗА: ОБЗОР ЛИТЕРАТУРЫ И АНАЛИЗ КЛИНИЧЕСКОГО НАБЛЮДЕНИЯAlmyashevA. Z.АльмяшевА. З.
Russian Federation
almyashev_2005@mail.ruN. P. Ogarev Mordovia State University, SaranskФГБОУ ВПО «Мордовский государственный университет им. Н.П. Огарева», Саранск150420133410141504201515042015Copyright ©; 2013, Almyashev A.Z.Copyright ©; 2013, Альмяшев А.З.2013Almyashev A.Z.Альмяшев А.З.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/20

Different variants of the ectopic thyroid are rarely encountered in routine clinical practice and associated with a defect in thyroid embryo-genesis at its early stages. The symptoms depend on the site and sizes of the ectopic thyroid, its function and morphological structure. Its diagnosis is based on radiologic studies. Hormone suppression, radioiodine ablation, and surgery are treatment choices.

Различные варианты эктопии щитовидной железы (ЩЖ) редко встречаются в рутинной клинической практике и связаны с дефектом тиреоидного эмбриогенеза на ранних его этапах. Симптомы зависят от локализации и размеров эктопированной ЩЖ, ее функции и морфологической структуры. Диагностика основана на лучевых методах исследования. Выбор метода лечения: гормональная супрессия, радиойодабляция, хирургия.

ectopic thyroidsymptomsdiagnosis, treatmentтиреоидная эктопиясимптомыдиагностикалечение1. Ibrahim N. A., Fadeyibi I. O. Ectopic thyroid: etiology, pathology and management.Ibrahim N. A., Fadeyibi I. O. Ectopic thyroid: etiology, pathology and management.Hormones 2011;10(4):261–9.2. Larochelle D., Arcand P., Belzile M., Gagnon N. B. Ectopic thyroid tissue – a review of the literature. J Otolaryngol 1979;8:523–30.Larochelle D., Arcand P., Belzile M., Gagnon N. B. Ectopic thyroid tissue – a review of the literature. J Otolaryngol 1979;8:523–30.3. Felice M. D., Lauro R. D. Thyroid development and its disorders: genetic and molecular mechanisms. Endocrine Reviews 2004;25:722–46.Felice M. D., Lauro R. D. Thyroid development and its disorders: genetic and molecular mechanisms. Endocrine Reviews 2004;25:722–46.4. Gillam M. P., Kopp P. Genetic regulation of thyroid development. Curr Opin Pediatr 2001;13:358–63.Gillam M. P., Kopp P. Genetic regulation of thyroid development. Curr Opin Pediatr 2001;13:358–63.5. Nitsch R., Di Dato V., di Gennaro A. et al. Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene. BMC Genomics 2010;11:306.Nitsch R., Di Dato V., di Gennaro A. et al. Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene. BMC Genomics 2010;11:306.6. Silberschmidt D., Rodriguez-Mallon A., Mithboakar P. et al. In vivo role of different domains and of phosphorylation in the transcription factor Nkx2–1. BMC Dev Biol 2011;11:9.Silberschmidt D., Rodriguez-Mallon A., Mithboakar P. et al. In vivo role of different domains and of phosphorylation in the transcription factor Nkx2–1. BMC Dev Biol 2011;11:9.7. Evuboglu E., Kapan M., Ipek T. et al. Ectopic thyroid in the abdomen: report of a case. Surg Today 1999;29:472–4.Evuboglu E., Kapan M., Ipek T. et al. Ectopic thyroid in the abdomen: report of a case. Surg Today 1999;29:472–4.8. Kalan A., Tariq M. Lingual thyroid gland: clinical evaluation and comprehensive management. Ear Nose Throat J 1999;78:340–1, 345–9.Kalan A., Tariq M. Lingual thyroid gland: clinical evaluation and comprehensive management. Ear Nose Throat J 1999;78:340–1, 345–9.9. Kansal P., Sakati N., Rifai A., Woodhouse N. Lingual thyroid. Diagnosis and treatment. Arch Intern Med 1987;147:2046–8.Kansal P., Sakati N., Rifai A., Woodhouse N. Lingual thyroid. Diagnosis and treatment. Arch Intern Med 1987;147:2046–8.10. Sung Y. M., Lee K. S., Han J., Cho E. Y. Intratracheal ectopic thyroid tissue with adenomatous hyperplasia in a pregnant woman. Am J Roentgenol 2008;190:161–3.Sung Y. M., Lee K. S., Han J., Cho E. Y. Intratracheal ectopic thyroid tissue with adenomatous hyperplasia in a pregnant woman. Am J Roentgenol 2008;190:161–3.11. Wong R. J., Cunningham M. J., Curtin H. D. Cervical ectopic thyroid. Am J Otolaryngol 1998;19:397–400.Wong R. J., Cunningham M. J., Curtin H. D. Cervical ectopic thyroid. Am J Otolaryngol 1998;19:397–400.12. Ibrahim N. A., Oludara M. A. Lateral cervical ectopic thyroid masses with eutopic multinodular goiter: an unusual presentation. Hormones (Athens) 2009;8:150–3.Ibrahim N. A., Oludara M. A. Lateral cervical ectopic thyroid masses with eutopic multinodular goiter: an unusual presentation. Hormones (Athens) 2009;8:150–3.13. Malone Q., Conn J., Gonzales M. et al. Ectopic pituitary fossa thyroid tissue. J Clin Neurosci 1997;4:360–3.Malone Q., Conn J., Gonzales M. et al. Ectopic pituitary fossa thyroid tissue. J Clin Neurosci 1997;4:360–3.14. Tiberti A., Damato B., Hiscott P., Vora J. Iris ectopic thyroid tissue: report of a case. Arch Ophthalmol 2006;124:1497–500.Tiberti A., Damato B., Hiscott P., Vora J. Iris ectopic thyroid tissue: report of a case. Arch Ophthalmol 2006;124:1497–500.15. Cicek Y., Tasci H., Gokdogan C. et al. Intra-abdominal ectopic thyroid. Br J Surg 1993;80:316.Cicek Y., Tasci H., Gokdogan C. et al. Intra-abdominal ectopic thyroid. Br J Surg 1993;80:316.16. Comajuan S. M., Ayerbe J. L., Ferrer B. R. et al. An intracardiac ectopic thyroid mass. Eur J Echocardiogr 2009;10:704–6.Comajuan S. M., Ayerbe J. L., Ferrer B. R. et al. An intracardiac ectopic thyroid mass. Eur J Echocardiogr 2009;10:704–6.17. Ghanem N., Bley Y., Altehoefer C. et al. Ectopic thyroid gland in the Porta Hepatis and Lingua. Thyroid 2003;13:503–7.Ghanem N., Bley Y., Altehoefer C. et al. Ectopic thyroid gland in the Porta Hepatis and Lingua. Thyroid 2003;13:503–7.18. Hagiuda J., Kuroda I., Tsukamoto T. Ectopic thyroid in an adrenal mass: a case report. BMC Urol 2006;6:18.Hagiuda J., Kuroda I., Tsukamoto T. Ectopic thyroid in an adrenal mass: a case report. BMC Urol 2006;6:18.19. Harach H. R. Ectopic thyroid tissue adjacent to the gallbladder. Histopathology 1998;32:90–1.Harach H. R. Ectopic thyroid tissue adjacent to the gallbladder. Histopathology 1998;32:90–1.20. Hoda S. A., Huvos A. G. Struma salpingis associated with struma ovarii. Am J Surg Pathol 1993;17:1187–9.Hoda S. A., Huvos A. G. Struma salpingis associated with struma ovarii. Am J Surg Pathol 1993;17:1187–9.21. Kuffner H. A., McCook B.M., Swaminatha R. et al. Controversial ectopic thyroid: a case report of thyroid tissue in the axilla and benign total thyroidectomy. Thyroid 2005;15:1095–7.Kuffner H. A., McCook B.M., Swaminatha R. et al. Controversial ectopic thyroid: a case report of thyroid tissue in the axilla and benign total thyroidectomy. Thyroid 2005;15:1095–7.22. Liang K., Liu J. F., Wang Y. H. et al. Ectopic thyroid presenting as a gallbladder mass. Ann R Coll Surg Engl 2010;92:4–6.Liang K., Liu J. F., Wang Y. H. et al. Ectopic thyroid presenting as a gallbladder mass. Ann R Coll Surg Engl 2010;92:4–6.23. Ozpolat B., Dogan O. V., Gökaslan G. et al. Ectopic thyroid gland on the ascending aorta with a partial pericardial defect: report of a case. Surg Today 2007;37:486–8.Ozpolat B., Dogan O. V., Gökaslan G. et al. Ectopic thyroid gland on the ascending aorta with a partial pericardial defect: report of a case. Surg Today 2007;37:486–8.24. Roth L. M., Miller A. W., Talerman A. M. Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol 2008;27:496–506.Roth L. M., Miller A. W., Talerman A. M. Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol 2008;27:496–506.25. Salam M. A. Ectopic thyroid mass adherent to the oesophagus. J Laryngol Otol 1992;106:746–7.Salam M. A. Ectopic thyroid mass adherent to the oesophagus. J Laryngol Otol 1992;106:746–7.26. Shah B. C., Ravichand C. S., Juluri S. et al. Ectopic thyroid cancer. Ann Thorac Cardiovasc Surg 2007;13:122–4.Shah B. C., Ravichand C. S., Juluri S. et al. Ectopic thyroid cancer. Ann Thorac Cardiovasc Surg 2007;13:122–4.27. Spinner R. J., Moor K. L., Gottfried M. R. et al. Thoracic intrathymic thyroid. Ann Surg 1994;220:91–6.Spinner R. J., Moor K. L., Gottfried M. R. et al. Thoracic intrathymic thyroid. Ann Surg 1994;220:91–6.28. Takahashi T., Ishikura H., Kato H. et al. Ectopic thyroid follicles in the submucosa of the duodenum. Virchows Arch A Pathol Anat Histopathol 1991;418:547–50.Takahashi T., Ishikura H., Kato H. et al. Ectopic thyroid follicles in the submucosa of the duodenum. Virchows Arch A Pathol Anat Histopathol 1991;418:547–50.29. Huang T. S., Chen H. Y. Dual thyroid ectopia with a normally located pretracheal thyroid gland: case report and literature review. Head Neck 2007;29:885–8.Huang T. S., Chen H. Y. Dual thyroid ectopia with a normally located pretracheal thyroid gland: case report and literature review. Head Neck 2007;29:885–8.30. Misaki T., Koh T., Shimbo S. et al. Dual-site thyroid ectopy in a mother and son. Thyroid 1992;2:325–7.Misaki T., Koh T., Shimbo S. et al. Dual-site thyroid ectopy in a mother and son. Thyroid 1992;2:325–7.31. Basaria S., Cooper D. S. Graves’ disease and recurrent ectopic thyroid tissue. Thyroid 1999;9:1261–4.Basaria S., Cooper D. S. Graves’ disease and recurrent ectopic thyroid tissue. Thyroid 1999;9:1261–4.32. Gunqor B., Kebat T., Ozaslan C., Akilli S. Intraabdominal ectopic thyroid presenting with hyperthyroidism: report of a case. Surg Today 2002;32:148–50.Gunqor B., Kebat T., Ozaslan C., Akilli S. Intraabdominal ectopic thyroid presenting with hyperthyroidism: report of a case. Surg Today 2002;32:148–50.33. Intenzo C. M., dePapp A.E., Jabbour S. et al. Scintigraphic manifestations of thyrotoxicosis. Radiographics 2003;23:857–69.Intenzo C. M., dePapp A.E., Jabbour S. et al. Scintigraphic manifestations of thyrotoxicosis. Radiographics 2003;23:857–69.34. Kamijo K. Lingual thyroid associated with Graves’ disease graves’ ophtalmopathy. Thyroid 2005;15:1407–8.Kamijo K. Lingual thyroid associated with Graves’ disease graves’ ophtalmopathy. Thyroid 2005;15:1407–8.35. Kumar R., Gupta R., Bal C. S. et al. Thyrotoxicosis in a patient with submandibular thyroid. Thyroid 2000;10:363–5.Kumar R., Gupta R., Bal C. S. et al. Thyrotoxicosis in a patient with submandibular thyroid. Thyroid 2000;10:363–5.36. Rahbar R., Yoon M. J., Connolly L. P. et al. Lingual thyroid in children: a rare clinical entity. Laryngoscope 2008;118:1174–9.Rahbar R., Yoon M. J., Connolly L. P. et al. Lingual thyroid in children: a rare clinical entity. Laryngoscope 2008;118:1174–9.37. Tojo K. Lingual thyroid presenting as acquired hypothyroidism in the adulthood. Inter Med 1998;37:381–4.Tojo K. Lingual thyroid presenting as acquired hypothyroidism in the adulthood. Inter Med 1998;37:381–4.38. Shakir K. M. Lingual thyroid associated with hypothyroidism and lymphomatous thy-roiditis: a case report. Mil Med 1982;147:591.Shakir K. M. Lingual thyroid associated with hypothyroidism and lymphomatous thy-roiditis: a case report. Mil Med 1982;147:591.39. Wein R. O., Norante J. D. Hashimoto’s thyroiditis within ectopic thyroid gland mimicking the presentation of thyroglossal duct cyst. Otolaryngol Head Neck Surg 2001;125:274–6.Wein R. O., Norante J. D. Hashimoto’s thyroiditis within ectopic thyroid gland mimicking the presentation of thyroglossal duct cyst. Otolaryngol Head Neck Surg 2001;125:274–6.40. Mishriki Y. Y., Lane B. P., Lozowski M. S., Epstein H. Hurthle cell tumour arising in the mediastinal ectopic thyroid and diagnosed by fine needle aspiration: light microscopic and ultrastructural features. Acta Cytol 1983;27:188–92.Mishriki Y. Y., Lane B. P., Lozowski M. S., Epstein H. Hurthle cell tumour arising in the mediastinal ectopic thyroid and diagnosed by fine needle aspiration: light microscopic and ultrastructural features. Acta Cytol 1983;27:188–92.41. Tucci J., Rulli F. Follicular carcinoma in ectopic thyroid gland. A case report. G Chir 1999;20:97–9.Tucci J., Rulli F. Follicular carcinoma in ectopic thyroid gland. A case report. G Chir 1999;20:97–9.42. Wang Y. J., Chu P. Y., Tai S. K. Ectopic thyroid papillary carcinoma presenting as bilateral neck masses. J Chin Med Assoc 2010;73:219–21.Wang Y. J., Chu P. Y., Tai S. K. Ectopic thyroid papillary carcinoma presenting as bilateral neck masses. J Chin Med Assoc 2010;73:219–21.43. Yaday S., Singh I., Singh J., Aggarwal N.Medullary carcinoma in a lingual thyroid. Singapore Med J 2008;49:251–3.Yaday S., Singh I., Singh J., Aggarwal N.Medullary carcinoma in a lingual thyroid. Singapore Med J 2008;49:251–3.44. Demirag F., Cakir E., Aydin E. et al. Ectopic primary B cell lymphoma of the thyroid presenting as an anterior mediastinal mass. A case report. Acta Chir Belg 2009;109:802–4.Demirag F., Cakir E., Aydin E. et al. Ectopic primary B cell lymphoma of the thyroid presenting as an anterior mediastinal mass. A case report. Acta Chir Belg 2009;109:802–4.45. Ranaldi R., Morichetti D., Goteri D., Martino A. Immature teratoma of the mediastinum arising in ectopic thyroid tissue; a case report. Anal Quant Cytol Histol 2009;31:233–8.Ranaldi R., Morichetti D., Goteri D., Martino A. Immature teratoma of the mediastinum arising in ectopic thyroid tissue; a case report. Anal Quant Cytol Histol 2009;31:233–8.46. Toso A., Colombani F., Averono G. et al. Lingual thyroid causingdysphagia and dyspnoea. Case reports and review of the literature. Acta Otorhinolaryngol Ital 2009;29:213–7.Toso A., Colombani F., Averono G. et al. Lingual thyroid causingdysphagia and dyspnoea. Case reports and review of the literature. Acta Otorhinolaryngol Ital 2009;29:213–7.47. Koch C. A., Picken C., Clement S. C. et al. Ectopic lingual thyroid: an otolaryngo-logic emergency beyond childhood. Thyroid 2000;10:511–4.Koch C. A., Picken C., Clement S. C. et al. Ectopic lingual thyroid: an otolaryngo-logic emergency beyond childhood. Thyroid 2000;10:511–4.48. Barnes T. W., Olsen K. D., Morgenthaler T. I. Obstructive lingual thyroid causing sleep apnoea: a case report and review of the literature. Sleep Med 2004;5:605–7.Barnes T. W., Olsen K. D., Morgenthaler T. I. Obstructive lingual thyroid causing sleep apnoea: a case report and review of the literature. Sleep Med 2004;5:605–7.49. Choi J. Y., Kim J. H. Case of an ectopic thyroid gland at the lateral neck masquerading as a metastatic papillary thyroid carcinoma. J Korean Med Sci 2008;23:548–50.Choi J. Y., Kim J. H. Case of an ectopic thyroid gland at the lateral neck masquerading as a metastatic papillary thyroid carcinoma. J Korean Med Sci 2008;23:548–50.50. Aklotun C., Demir H., Berk F., Metin K. K. Diagnosis of complete ectopic lingual thyroid with Tc-99m pertechnetate scintigraphy. Clin Nucl Med 2001;26:933–5.Aklotun C., Demir H., Berk F., Metin K. K. Diagnosis of complete ectopic lingual thyroid with Tc-99m pertechnetate scintigraphy. Clin Nucl Med 2001;26:933–5.51. Al-Jurayyan N. A., El-Desouki M. I. Transient iodine organification defect in infants with ectopic thyroid glands. Clin Nucl Med 1997;22:13–16.Al-Jurayyan N. A., El-Desouki M. I. Transient iodine organification defect in infants with ectopic thyroid glands. Clin Nucl Med 1997;22:13–16.52. Sood A., Kumar R. The ectopic thyroid gland and the role of nuclear medicine techniques in its diagnosis and management. Hell J Nucl Med 2008;11(3):168–71.Sood A., Kumar R. The ectopic thyroid gland and the role of nuclear medicine techniques in its diagnosis and management. Hell J Nucl Med 2008;11(3):168–71.53. Djemli A., Fillion M., Belgoudi J. et al. Twenty years later: a re-evaluation of the contribution of plasma thyroglobulin to the diagnosis of thyroid dysgenesis in infants with congenital hypothyroidism. Clin Biochem 2004;37:818–22.Djemli A., Fillion M., Belgoudi J. et al. Twenty years later: a re-evaluation of the contribution of plasma thyroglobulin to the diagnosis of thyroid dysgenesis in infants with congenital hypothyroidism. Clin Biochem 2004;37:818–22.54. El-Desouki M., Al-Jurayyan N.,El-Desouki M., Al-Jurayyan N.,Al-Nuaim A. et al. Thyroid scintigraphy and perchlorate discharge test in the diagnosis ofcongenital hypothyroidism. Eur J Nucl Med 1995;22:1005–8.55. Iglesias P., Olmos-García R., Riva B., Díez J. J. Iodine 131 and lingual thyroid.J Clin Endocrinol Metab 2008;93:4198–9.Iglesias P., Olmos-García R., Riva B., Díez J. J. Iodine 131 and lingual thyroid.J Clin Endocrinol Metab 2008;93:4198–9.56. Lim-Dunham J. E., Feinstein K. A., Yousefzadeh D. K., Ben-Ami T. Sonographic demonstration of a normal thyroid gland excludes ectopic thyroid in patients with thyroglossal duct cyst. Am J Roentgenol 1995;164:1489–91.Lim-Dunham J. E., Feinstein K. A., Yousefzadeh D. K., Ben-Ami T. Sonographic demonstration of a normal thyroid gland excludes ectopic thyroid in patients with thyroglossal duct cyst. Am J Roentgenol 1995;164:1489–91.57. Ohnishi H., Sato H., Noda H. et al. Color Doppler ultrasonography: diagnosis of ectopic thyroid gland in patients with congenital hypothyroidism caused by thyroid dysgenesis. J Clin Endocrinol Metab 2003;88:5145–9.Ohnishi H., Sato H., Noda H. et al. Color Doppler ultrasonography: diagnosis of ectopic thyroid gland in patients with congenital hypothyroidism caused by thyroid dysgenesis. J Clin Endocrinol Metab 2003;88:5145–9.58. Hari C. K., Kumar M., Abo-Khatwa M. M. et al. Follicular variant of papillary carcinoma arising from lingual thyroid. Ear Nose Throat J 2009;88:E7.Hari C. K., Kumar M., Abo-Khatwa M. M. et al. Follicular variant of papillary carcinoma arising from lingual thyroid. Ear Nose Throat J 2009;88:E7.59. Mussak E. N., Kacker A. Surgical and medical management of midline ectopic thyroid. Otolaryngol Head Neck Surg 2007;136:870–2.Mussak E. N., Kacker A. Surgical and medical management of midline ectopic thyroid. Otolaryngol Head Neck Surg 2007;136:870–2.60. Al-Samarrai A. Y., Crankson S. J., Al-Jobori A. Autotransplantation of lingual thyroid into the neck. Br J Surg 1988;75:287.Al-Samarrai A. Y., Crankson S. J., Al-Jobori A. Autotransplantation of lingual thyroid into the neck. Br J Surg 1988;75:287.61. Bodner J., Fish J., Lottersberger A. C. et al. Robotic resection of an ectopic goiter in the mediastinum. Surg Laparosc Endosc Percutan Tech 2005;15:249–51.Bodner J., Fish J., Lottersberger A. C. et al. Robotic resection of an ectopic goiter in the mediastinum. Surg Laparosc Endosc Percutan Tech 2005;15:249–51.62. Hafidh M. A., Sheahan P., Khan N. A. et al. Role of CO2 laser in the management of obstructive ectopic lingual thyroids. J Laryngol Otol 2004;118:807–9.Hafidh M. A., Sheahan P., Khan N. A. et al. Role of CO2 laser in the management of obstructive ectopic lingual thyroids. J Laryngol Otol 2004;118:807–9.63. Rojananin S., Ungkanont K. Transposition of the lingual thyroid: a new alternative technique. Head Neck 1999;21:480–3.Rojananin S., Ungkanont K. Transposition of the lingual thyroid: a new alternative technique. Head Neck 1999;21:480–3.64. Terris D. J., Seybt M. W., Vaughters R. B. A new minimally invasive lingual thyroidectomy technique. Thyroid 2010;20:1367–9.Terris D. J., Seybt M. W., Vaughters R. B. A new minimally invasive lingual thyroidectomy technique. Thyroid 2010;20:1367–9.