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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">249</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2016-6-4-35-44</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">EPIGENETIC REGULATION OF GENE EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA: THERAPEUTIC PERSPECTIVES</article-title><trans-title-group xml:lang="ru"><trans-title>ЭПИГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ ГЕННОЙ ЭКСПРЕССИИ В РАЗВИТИИ ПЛОСКОКЛЕТОЧНОГО РАКА ГОЛОВЫ И ШЕИ: ТЕРАПЕВТИЧЕСКИЕ ПЕРСПЕКТИВЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Samsonov</surname><given-names>R. B.</given-names></name><name xml:lang="ru"><surname>Самсонов</surname><given-names>Р. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758; 11/1 Hoshimina St., Saint Petersburg 194356; 70 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758</p></bio><bio xml:lang="ru"><p>Роман Борисович Самсонов.</p><p>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 194356 Санкт-Петербург, ул. Хошимина, 11/1; 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 70, Rom_207@mail.ru</p></bio><email>Rom_207@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Radzhabova</surname><given-names>Z. A.</given-names></name><name xml:lang="ru"><surname>Раджабова</surname><given-names>З. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758</p></bio><bio xml:lang="ru"><p>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Cheburkin</surname><given-names>Yu. V.</given-names></name><name xml:lang="ru"><surname>Чебуркин</surname><given-names>Ю. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758; 11/1 Hoshimina St., Saint Petersburg 194356</p></bio><bio xml:lang="ru"><p>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 194356 Санкт-Петербург, ул. Хошимина, 11/1</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Klyuge</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Клюге</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758</p></bio><bio xml:lang="ru"><p>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tkachenko</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Ткаченко</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758</p></bio><bio xml:lang="ru"><p>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malek</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Малек</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758; 11/1 Hoshimina St., Saint Petersburg 194356</p></bio><bio xml:lang="ru"><p>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 194356 Санкт-Петербург, ул. Хошимина, 11/1</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Petrov Research Institute of Oncology</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт онкологии имени Н. Н. Петрова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Onco-system, Ltd</institution></aff><aff><institution xml:lang="ru">Онко-система, ООО</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Russian Research Center for Radiology and Surgical Technologies</institution></aff><aff><institution xml:lang="ru">Российский научный центр радиологии и хирургических технологий</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Onco-system,Ltd</institution></aff><aff><institution xml:lang="ru">Онко-система, ООО</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-12-08" publication-format="electronic"><day>08</day><month>12</month><year>2016</year></pub-date><volume>6</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>35</fpage><lpage>44</lpage><history><date date-type="received" iso-8601-date="2017-04-08"><day>08</day><month>04</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-04-08"><day>08</day><month>04</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Samsonov R.B., Radzhabova Z.A., Cheburkin Y.V., Klyuge V.A., Tkachenko E.V., Malek A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Самсонов Р.Б., Раджабова З.А., Чебуркин Ю.В., Клюге В.А., Ткаченко Е.В., Малек А.В.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Samsonov R.B., Radzhabova Z.A., Cheburkin Y.V., Klyuge V.A., Tkachenko E.V., Malek A.V.</copyright-holder><copyright-holder xml:lang="ru">Самсонов Р.Б., Раджабова З.А., Чебуркин Ю.В., Клюге В.А., Ткаченко Е.В., Малек А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/249">https://ogsh.abvpress.ru/jour/article/view/249</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>head and neck tumors</kwd><kwd>microRNAs</kwd><kwd>squamous cell carcinoma</kwd><kwd>epigenetics</kwd><kwd>antitumor therapy</kwd><kwd>histone deacetylase inhibitors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>опухоли головы и шеи</kwd><kwd>микрорнк</kwd><kwd>плоскоклеточный рак</kwd><kwd>эпигенетика</kwd><kwd>противоопухолевая терапия</kwd><kwd>ингибиторы деацетилаз гистонов</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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