Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press25010.17650/2222-1468-2016-6-4-45-48ORIGINAL REPORTОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕTHE ROLE OF BRAF MUTATION STATUS IN SURGICAL TREATMENT OF WELL-DIFFERENTIATED THYROID CANCERВЛИЯНИЕ СТАТУСА ГЕНА BRAF НА ВЫБОР ТАКТИКИ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ВЫСОКОДИФФЕРЕНЦИРОВАННОГО РАКА ЩИТОВИДНОЙ ЖЕЛЕЗЫPolyakovA. P.ПоляковА. П.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

Андрей Павлович Поляков.

125284 Москва, 2-й Боткинский проезд, 3, appolyakov@mail.ru

appolyakov@mail.ruVolchenkoN. N.ВолченкоН. Н.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

SlavnovaE. N.СлавноваЕ. Н.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

KudryavtsevaA. V.КудрявцеваА. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

RatushnyyM. V.РатушныйМ. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

RatushnayaV. V.РатушнаяВ. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

FilyushinM. M.ФилюшинМ. М.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

RebrikovaI. V.РебриковаИ. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

NikiforovichP. A.НикифоровичП. А.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow, 125284 

125284 Москва, 2-й Боткинский проезд, 3

P.A. Herzen Moscow Oncology Research Institute – Branch of National Medical Radiology Research CenterМосковский научно-исследовательский онкологический институт имени П.А. Герцена – филиал Национального медицинского радиологического исследовательского центра081220166445480804201708042017Copyright ©; 2016, Polyakov A.P., Volchenko N.N., Slavnova E.N., Kudryavtseva A.V., Ratushnyy M.V., Ratushnaya V.V., Filyushin M.M., Rebrikova I.V., Nikiforovich P.A.Copyright ©; 2016, Поляков А.П., Волченко Н.Н., Славнова Е.Н., Кудрявцева А.В., Ратушный М.В., Ратушная В.В., Филюшин М.М., Ребрикова И.В., Никифорович П.А.2016Polyakov A.P., Volchenko N.N., Slavnova E.N., Kudryavtseva A.V., Ratushnyy M.V., Ratushnaya V.V., Filyushin M.M., Rebrikova I.V., Nikiforovich P.A.Поляков А.П., Волченко Н.Н., Славнова Е.Н., Кудрявцева А.В., Ратушный М.В., Ратушная В.В., Филюшин М.М., Ребрикова И.В., Никифорович П.А.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/250

papillary thyroid carcinomawell-differentiated thyroid cancerBRAF genemutationsmetastasisпапиллярный рак щитовидной железывысокодифференцированный рак щитовидной железыген BRAFмутацииметастазирование1. Hodgson N.C., Button J., Solorzano C. et al. Thyroid cancer: is the incidence still increasing? Ann Surg Oncol 2004;11:1093–7.Hodgson N.C., Button J., Solorzano C. et al. Thyroid cancer: is the incidence still increasing? Ann Surg Oncol 2004;11:1093–7.2. Davies L., Welch H.G. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 2006;295(18):2164–7.Davies L., Welch H.G. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 2006;295(18):2164–7.3. Davies H., Bignell G.R., Cox C. et al. Mutations of the BRAF gene in human cancer. Nature 2002;417(6892):949–54.Davies H., Bignell G.R., Cox C. et al. Mutations of the BRAF gene in human cancer. Nature 2002;417(6892):949–54.4. Xing М. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr Rev 2007;28(7):742–62.Xing М. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr Rev 2007;28(7):742–62.5. Fugazzola L., Puxeddu E., Avenia N. et al. Correlation between В-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: data from a multicentric Italian study and review of the literature. Endocr Relat Cancer 2006;13(2): 455–64.Fugazzola L., Puxeddu E., Avenia N. et al. Correlation between В-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: data from a multicentric Italian study and review of the literature. Endocr Relat Cancer 2006;13(2): 455–64.6. Basolo F., Torregrossa L., Giannini R. et al. Сorrelation between the BRAF V600E Mutation and Tumor Invasiveness in Papillary Thyroid Carcinomas Smaller than 20 Millimeters: Analysis of 1060 Cases. J Clin Endocrinol Metab 2010;95(9):4197–4205. DOI: 10.1210/jc.2010-0337.Basolo F., Torregrossa L., Giannini R. et al. Сorrelation between the BRAF V600E Mutation and Tumor Invasiveness in Papillary Thyroid Carcinomas Smaller than 20 Millimeters: Analysis of 1060 Cases. J Clin Endocrinol Metab 2010;95(9):4197–4205. DOI: 10.1210/jc.2010-0337.7. Xing M., Westra W.H., Tufano R.P. et al. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 2005;90(12): 6373–9.Xing M., Westra W.H., Tufano R.P. et al. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 2005;90(12): 6373–9.8. Barollo S., Pennelli G., Vianello F. et al. BRAF in primary and recurrent papillary thyroid cancers: the relationship with (131)I and 2-[(18)F]fluoro-2-deoxy-D-glucose uptake ability. Eur J Endocrinol 2010;163(4):659–63.Barollo S., Pennelli G., Vianello F. et al. BRAF in primary and recurrent papillary thyroid cancers: the relationship with (131)I and 2-[(18)F]fluoro-2-deoxy-D-glucose uptake ability. Eur J Endocrinol 2010;163(4):659–63.9. Brose M.S., Schlumberger M., Peña C., Kappeler C. Sorafenib in radioactive iodinerefractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3. Lancet 2014;384(9940):319–28. DOI: 10.1016/S0140-6736(14)60421-9.Brose M.S., Schlumberger M., Peña C., Kappeler C. Sorafenib in radioactive iodinerefractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3. Lancet 2014;384(9940):319–28. DOI: 10.1016/S0140-6736(14)60421-9.