Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press26410.17650/2222-1468-2017-7-2-45-52DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИLENVATINIB IN TREATMENT OF RADIOACTIVE IODINE-REFRACTORY WELL-DIFFERENTIATED THYROID CARCINOMAЛЕНВАТИНИБ В ЛЕЧЕНИИ РАДИОЙОДРЕФРАКТЕРНОГО ВЫСОКОДИФФЕРЕНЦИРОВАННОГО РАКА ЩИТОВИДНОЙ ЖЕЛЕЗЫRomanovI. S.РомановИ. С.
Russian Federation

23 Kashira Highway, Moscow 115478

Илья Станиславович Романов.

115478 Москва, Каширское шоссе, 23

drromanov@mail.ruMudunovA. M.МудуновА. М.
Russian Federation

23 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 23

IsaevP. A.ИсаевП. А.
Russian Federation

4 Korolev St., Obninsk 249036, Kaluga Region

249036 Калужская область, Обнинск, ул. Королева, 4

BychkovYu. M.БычковЮ. М.
Russian Federation

86 Profsouznaya St., Moscow 117997

117997 Москва, ул. Профсоюзная, 86

DolgushinM. B.ДолгушинМ. Б.
Russian Federation

23 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 23

OdzharovaA. A.ОджароваА. А.
Russian Federation

23 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 23

RomanovaL. F.РомановаЛ. Ф.
Russian Federation

23 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 23

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава РоссииTsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaМедицинский радиологический научный центр им. А.Ф. Цыба – филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава РоссииRussian Scientific Center of RadiologyФГБУ «Российский научный центр рентгенорадиологии»260620177245522706201727062017Copyright ©; 2017, Romanov I.S., Mudunov A.M., Isaev P.A., Bychkov Y.M., Dolgushin M.B., Odzharova A.A., Romanova L.F.Copyright ©; 2017, Романов И.С., Мудунов А.М., Исаев П.А., Бычков Ю.М., Долгушин М.Б., Оджарова А.А., Романова Л.Ф.2017Romanov I.S., Mudunov A.M., Isaev P.A., Bychkov Y.M., Dolgushin M.B., Odzharova A.A., Romanova L.F.Романов И.С., Мудунов А.М., Исаев П.А., Бычков Ю.М., Долгушин М.Б., Оджарова А.А., Романова Л.Ф.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/264

Well-differentiated thyroid carcinoma (WDTC) comprises > 90 % of all cases of thyroid cancer. In 10–15 % of patients, distant metastases are detected which significantly worsen the prognosis. Radioactive iodine therapy remains the main type of treatment of this patient group, but for patients with so-called radioactive iodine-refractory WDTC the prognosis is very poor. After successful phase III  studies, several drugs from the group of multikinase inhibitors are being used in clinical practice for treatment of radioactive iodine-refractory WDTC, for example lenvatinib. In this article, we present a group of patients with radioactive iodine-refractory WDTC who received lenvatinib therapy.

Высокодифференцированные формы рака щитовидной железы (ВДРЩЖ) составляют >90 % всех случаев рака щитовидной железы. У 10–15  % больных обнаруживаются отдаленные метастазы, что крайне ухудшает прогноз. Терапия радиоактивным йодом остается основным видом лечения для этой группы больных, но для пациентов с так называемым радиойодрефрактерным ВДРЩЖ прогноз крайне неблагоприятный. Несколько препаратов из группы мультикиназных ингибиторов после успешных исследований III фазы в настоящее время вошли в клиническую практику при лечении радиойодрефрактерного ВДРЩЖ, в частности ленватиниб. В своей работе мы представляем группу пациентов с радиойодрефрактерным ВДРЩЖ, которым проводилась терапия препаратом ленватиниб.

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