Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press2710.17650/2222-1468-2013-0-4-23-28ORIGINAL REPORTSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯMEDULLARY THYROID CANCER AS PART OF MEN 2B SYNDROME. CASE REPORTМЕДУЛЛЯРНЫЙ РАК ЩИТОВИДНОЙ ЖЕЛЕЗЫ В СОСТАВЕ СИНДРОМА МЭН 2Б. КЛИНИЧЕСКИЙ СЛУЧАЙLyubchenkoL. N.ЛюбченкоЛ. Н.
Russian Federation
clingen@mail.ruAmosenkoF. A.АмосенкоФ. А.
Russian Federation
FilippovaM. G.ФилипповаМ. Г.
Russian Federation
DobrokhotovaV. Z.ДоброхотоваВ. З.
Russian Federation
MatyakinE. G.МатякинЕ. Г.
Russian Federation
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваI. M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, МоскваФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва150420133423281504201515042015Copyright ©; 2013, Lyubchenko L.N., Amosenko F.A., Filippova M.G., Dobrokhotova V.Z., Matyakin E.G.Copyright ©; 2013, Любченко Л.Н., Амосенко Ф.А., Филиппова М.Г., Доброхотова В.З., Матякин Е.Г.2013Lyubchenko L.N., Amosenko F.A., Filippova M.G., Dobrokhotova V.Z., Matyakin E.G.Любченко Л.Н., Амосенко Ф.А., Филиппова М.Г., Доброхотова В.З., Матякин Е.Г.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/27

MEN 2B syndrome is a subtype of the multiple endocrine neoplasia type 2. It is characterized by the development of aggressive forms of medullary thyroid cancer at an early age, pheochromocytoma and hyperparathyroid syndrome. This article provides an own clinical observation of the patient with MEN 2B syndrome associated with a mutation in the proto-oncogene RET.

Синдром МЭН 2Б является одним из подтипов синдрома множественных эндокринных неоплазий 2-го типа и характеризуется развитием агрессивных форм медуллярного рака щитовидной железы в раннем возрасте, высоким риском развития феохромоцитомы и гиперпаратиреоидного синдрома. В статье приводится собственное клиническое наблюдение пациента с синдромом МЭН 2Б, ассоциированным с герминальной мутацией в протоонкогене RET.

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