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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">270</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2017-7-2-92-98</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">PERISTOMAL RECURRENCE OF LARYNGEAL CANCER (LITERATURE REVIEW)</article-title><trans-title-group xml:lang="ru"><trans-title>АКТУАЛЬНЫЕ ВОПРОСЫ ПЕРИСТОМАЛЬНОГО РЕЦИДИВА РАКА ГОРТАНИ (ОБЗОР ЛИТЕРАТУРЫ)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Guz’</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Гузь</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>42 Blyukher Str., Chelyabinsk, 454018; 64 Vorovskoy Str., Chelyabinsk, 454092</p></bio><bio xml:lang="ru"><p>Александр Олегович Гузь.</p><p>454018, Челябинск, ул. Блюхера, 42; 454092, Челябинск, ул. Воровского, 64 </p></bio><email>guz_a_o@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zakharov</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Захаров</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>42 Blyukher Str., Chelyabinsk, 454018; 64 Vorovskoy Str., Chelyabinsk, 454092</p></bio><bio xml:lang="ru"><p>454018, Челябинск, ул. Блюхера, 42; 454092, Челябинск, ул. Воровского, 64</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Garev</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Гарев</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>42 Blyukher Str., Chelyabinsk, 454018; 64 Vorovskoy Str., Chelyabinsk, 454092</p></bio><bio xml:lang="ru"><p>454018, Челябинск, ул. Блюхера, 42; 454092, Челябинск, ул. Воровского, 64</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Chelyabinsk Regional Clinical Oncology Dispensary</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Челябинский областной клинический онкологический диспансер»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">South Ural State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-06-26" publication-format="electronic"><day>26</day><month>06</month><year>2017</year></pub-date><volume>7</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>92</fpage><lpage>98</lpage><history><date date-type="received" iso-8601-date="2017-06-27"><day>27</day><month>06</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-06-27"><day>27</day><month>06</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Guz’ A.O., Zakharov A.S., Garev A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Гузь А.О., Захаров А.С., Гарев А.В.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Guz’ A.O., Zakharov A.S., Garev A.V.</copyright-holder><copyright-holder xml:lang="ru">Гузь А.О., Захаров А.С., Гарев А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/270">https://ogsh.abvpress.ru/jour/article/view/270</self-uri><abstract xml:lang="en"><p>Treatment of recurrent laryngeal cancer remains challenging for clinicians. Peristomal reccurence is one of the severest complications of laryngeal cancer that occurs in 2–15  % of patients after laryngectomy and has a poor prognosis: the two-year survival rate is 45 % in patients with stage I and stage II recurrence (according to G.A. Sisson) and 9 % among patients with stage III and stage IV recurrence. Stomal recurrence usually occurs within 2 years after surgery. The following factors can influence that: location of the tumor in the subglottic region of the larynx, size of the primary tumor, presence of regional metastases, placement of a tracheostoma before laryngectomy, and submucosal spread of the tumor to the trachea. All these factors should be taken into account in patients» management, including prescription of adjuvant therapy and choosing a treatment strategy in patients with primary disease.</p><p>Since there are multiple factors that can influence peristomal reccurence development, the disease requires comprehensive evaluation in order to provide the most adequate treatment and to prevent stomal recurrence.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>laryngeal cancer</kwd><kwd>risk factors</kwd><kwd>peristomal recurrence</kwd><kwd>laryngectomy</kwd><kwd>lymphadenectomy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак гортани</kwd><kwd>факторы риска</kwd><kwd>перистомальный рецидив</kwd><kwd>ларингэтомия</kwd><kwd>лимфаденэктомия.</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Petrovic Z., Djordjevic V. 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