Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press3110.17650/2222-1468-2014-0-2-4-9ORIGINAL REPORTSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯANALYSIS OF THE RESULTS OF SURGICAL TREATMENT FOR RECURRENT OROPHARYNGEAL CANCERАНАЛИЗ РЕЗУЛЬТАТОВ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ РЕЦИДИВОВ РАКА РОТОГЛОТКИKropotovM. A.КропотовМ. А.
Russian Federation
drKropotov@mail.ruIlkaevK. D.ИлькаевК. Д.
Russian Federation
drKropotov@mail.ruDronovaE. L.ДроноваЕ. Л.
Russian Federation
drKropotov@mail.ruN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowНИИ клинической онкологии ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва1504201442491604201516042015Copyright ©; 2014, Kropotov M.A., Ilkaev K.D., Dronova E.L.Copyright ©; 2014, Кропотов М.А., Илькаев К.Д., Дронова Е.Л.2014Kropotov M.A., Ilkaev K.D., Dronova E.L.Кропотов М.А., Илькаев К.Д., Дронова Е.Л.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/31

The paper analyzes the results of surgical treatment in 57 patients with recurrent oropharyngeal cancer after an ineffective chemoradiaton therapy cycle performed in 1995 to 2014.

It shows that it is important to estimate the extent of a tumor process by different methods and to choose a surgical approach.

В работе представлен анализ результатов хирургического лечения рецидивов рака ротоглотки, проведенного 57 пациентам после неэффективного курса химиолучевого лечения в период с 1995 по 2014 г.

Показана важность оценки распространенности опухолевого процесса разными методами и выбора оперативного доступа.

oropharyngeal cancerrecurrencechemoradiaton therapysurgical approachmandibulotomyрак ротоглоткирецидивхимиолучевое лечениехирургический доступмандибулотомия1. Kreimer A. R., Clifford G. M., Boyle P., Franceschi S. Human pappilomavirus types in head and neck squamous cell carcinomas worldwide: a systemic review. Cancer Epidemiol Biomarkers Prew 2005; 14:465–75.Kreimer A. R., Clifford G. M., Boyle P., Franceschi S. Human pappilomavirus types in head and neck squamous cell carcinomas worldwide: a systemic review. Cancer Epidemiol Biomarkers Prew 2005; 14:465–75.2. D’Souza G., Kreimer A. R., Viscidi R. et al. Case-control study of human papillomavirus and oropharyngeal cancer. New England J Med 2007:356:1944–56.D’Souza G., Kreimer A. R., Viscidi R. et al. Case-control study of human papillomavirus and oropharyngeal cancer. New England J Med 2007:356:1944–56.3. Parkhill E. M. Tumors of the palatine tonsil. In: Dockerty M. B., Parkhill E. M., Dahlin D. C., eds. Tumors of the Oral Cavity and Pharynx. Washington, DC: Armed Forces Institute of Pathology, 1964. P. 243.Parkhill E. M. Tumors of the palatine tonsil. In: Dockerty M. B., Parkhill E. M., Dahlin D. C., eds. Tumors of the Oral Cavity and Pharynx. Washington, DC: Armed Forces Institute of Pathology, 1964. P. 243.4. Кропотов М. А., Епихина А. В. Хирургические аспекты лечения рака ротоглотки. Опухоли головы и шеи 2011;2:5–13.Кропотов М. А., Епихина А. В. Хирургические аспекты лечения рака ротоглотки. Опухоли головы и шеи 2011;2:5–13.5. Федотенко С. П., Романов И. С. Злокачественные опухоли головы и шеи. В кн.: Руководство по химиотерапии опухолевых заболеваний. Под ред. Н. И. Переводчиковой.Федотенко С. П., Романов И. С. Злокачественные опухоли головы и шеи. В кн.: Руководство по химиотерапии опухолевых заболеваний. Под ред. Н. И. Переводчиковой.М., 2011. 6. Vermorken J. B., Mesia R., Rivera F. et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359:1116–27. 7. Vu H. L., Sikora A. G., Fu S., Kao J. HPV-induced oropharengeal cancer, immune response and response to therapy. Cancer Lett 2010;288:149–55. 8. Hitt R. Randomised clinical trials of induction chemotherapy with either cisplatin 5-fluoracil or docetaxel cisplatin 5-fluoracil followed by chemoradiotherapy for patients with unresectable locally advanced head and neck cancer. American Society of Clinical Oncology. 42 nd Meeting, 2006.М., 2011. 6. Vermorken J. B., Mesia R., Rivera F. et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359:1116–27. 7. Vu H. L., Sikora A. G., Fu S., Kao J. HPV-induced oropharengeal cancer, immune response and response to therapy. Cancer Lett 2010;288:149–55. 8. Hitt R. Randomised clinical trials of induction chemotherapy with either cisplatin 5-fluoracil or docetaxel cisplatin 5-fluoracil followed by chemoradiotherapy for patients with unresectable locally advanced head and neck cancer. American Society of Clinical Oncology. 42 nd Meeting, 2006.9. Korner G. Capecitabine plus reirradiation in patients with recurrent squamous cell carcinoma of the head and neck. American Society of Clinical Oncology. 42 Meeting, 2006.Korner G. Capecitabine plus reirradiation in patients with recurrent squamous cell carcinoma of the head and neck. American Society of Clinical Oncology. 42 Meeting, 2006.10. Donald P. J. The difficult case in head and neck cancer surgery. NY: Thieme, 2010. ndDonald P. J. The difficult case in head and neck cancer surgery. NY: Thieme, 2010. nd11. Litton W. B., Krause C. J. Surgical management of carcinoma of the oral cavity. Otolaryngol Clin North Am 1972;5:303–20.Litton W. B., Krause C. J. Surgical management of carcinoma of the oral cavity. Otolaryngol Clin North Am 1972;5:303–20.12. Mendenhall W. M., Amdur R. J., Stringer S. P. et al. Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol 2000 Jun;18(11):2219–25.Mendenhall W. M., Amdur R. J., Stringer S. P. et al. Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol 2000 Jun;18(11):2219–25.13. Gleich L. L., Collins C. M., Gartside P. S. Therapeutic decision making in stages III and IV head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2003 Jan;129(1):26–35.Gleich L. L., Collins C. M., Gartside P. S. Therapeutic decision making in stages III and IV head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2003 Jan;129(1):26–35.14. Krause C. J. Personal communications, 1980.Krause C. J. Personal communications, 1980.15. Kreeft A. M., Tan I. B., Leemans C.R., Balm A.J. The surgical dilemma in advanced oral and oropharyngeal cancer: how we do it. Clin Otolaryngol 2011;36:260–6.Kreeft A. M., Tan I. B., Leemans C.R., Balm A.J. The surgical dilemma in advanced oral and oropharyngeal cancer: how we do it. Clin Otolaryngol 2011;36:260–6.16. Toomey J. M. Cyst and tumors of the pharynx. In: Paparella M. M., Shumric D. A., eds. Otolaryngology. Vol. 3. 2 ed. Philadelphia: WB Saunders, 1980. P. 2323.Toomey J. M. Cyst and tumors of the pharynx. In: Paparella M. M., Shumric D. A., eds. Otolaryngology. Vol. 3. 2 ed. Philadelphia: WB Saunders, 1980. P. 2323.17. Lindberg R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1972;29:1446–9.Lindberg R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1972;29:1446–9.18. Truluck C. H. Jr, Putney F. R. Survival rates in cancer of the tongue, tonsil and hypopharynx. Arch Otolaryngol 1971;93:271–4.Truluck C. H. Jr, Putney F. R. Survival rates in cancer of the tongue, tonsil and hypopharynx. Arch Otolaryngol 1971;93:271–4.19. Civantos F. J., Goodwin J. W. Cancer of the oropharynx. In: Myers E. N., Suen J. Y., eds. Cancer of the Head and Neck. 3 rnd ed. Philadelphia: WB Saunders, 1989. Pр. 361–380.Civantos F. J., Goodwin J. W. Cancer of the oropharynx. In: Myers E. N., Suen J. Y., eds. Cancer of the Head and Neck. 3 rnd ed. Philadelphia: WB Saunders, 1989. Pр. 361–380.20. Fletcher G. H., Jesse R. H., Healey J. E. et al. Oropharynx. In: MacComb W. S., Fletcher G. H., eds. Cancer of the Head and Neck. Baltimore: Williams and Wilkins, 1968. P. 180.Fletcher G. H., Jesse R. H., Healey J. E. et al. Oropharynx. In: MacComb W. S., Fletcher G. H., eds. Cancer of the Head and Neck. Baltimore: Williams and Wilkins, 1968. P. 180.21. Whicker J. H., DeSanto L. W., Devine K. D. Surgical treatment of squamous cell carcinoma of the base of the tongue. Laryngoscope 1972;82:1853–60.Whicker J. H., DeSanto L. W., Devine K. D. Surgical treatment of squamous cell carcinoma of the base of the tongue. Laryngoscope 1972;82:1853–60.22. Lee J. G. Resection margins of the carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: a clinical study. Master’s thesis, University of Iowa, 1973.Lee J. G. Resection margins of the carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: a clinical study. Master’s thesis, University of Iowa, 1973.23. Vidic B., Melloni B. J. Applied anatomy of the oral cavity and related structures. Otolaryngol Clin North Am 1979;12:3–14.Vidic B., Melloni B. J. Applied anatomy of the oral cavity and related structures. Otolaryngol Clin North Am 1979;12:3–14.24. Kreeft A. M., van der Molen L., Hilgers F. J., Balm A. J. Speech and swallowing after surgical treatment of advanced oral and oropharyngeal carcinoma: a systematic review of the literature. Eur Arch Otolaryngol 2009;266:1687–98.Kreeft A. M., van der Molen L., Hilgers F. J., Balm A. J. Speech and swallowing after surgical treatment of advanced oral and oropharyngeal carcinoma: a systematic review of the literature. Eur Arch Otolaryngol 2009;266:1687–98.25. Реконструктивные операции при опухолях головы и шеи. Под ред. Е. Г. Матякина. М.: Вердана, 2009. 26. Banfi A., Bonadonna G., Carnevali G. et al. Lymphoreticular sarcomas with primary involvement of Waldeyer’s ring. Clinical evaluation of 225 cases. Cancer 1970;26:341–51.Реконструктивные операции при опухолях головы и шеи. Под ред. Е. Г. Матякина. М.: Вердана, 2009. 26. Banfi A., Bonadonna G., Carnevali G. et al. Lymphoreticular sarcomas with primary involvement of Waldeyer’s ring. Clinical evaluation of 225 cases. Cancer 1970;26:341–51.27. Wang C. C. Radiation therapy in the management of oral malignant disease. Otolaryngol Clin North Am 1979;12:73–80.Wang C. C. Radiation therapy in the management of oral malignant disease. Otolaryngol Clin North Am 1979;12:73–80.28. Shah J. P., Pattel S. G. Head and neck surgery and oncology. New York: Mosby, 2003.Shah J. P., Pattel S. G. Head and neck surgery and oncology. New York: Mosby, 2003.29. Moore D. M., Calcaterra T. C. Cancer of the tongue base treated by transpharyngeal approach. Ann Otol Rhinol Laryngol 1990;99:300–3.Moore D. M., Calcaterra T. C. Cancer of the tongue base treated by transpharyngeal approach. Ann Otol Rhinol Laryngol 1990;99:300–3.30. Quenelle D. J., Crissman J. D., Shumrick D. A. Tonsillar carcinoma – treatment results. Laryngoscope 1979;89:1842–6.Quenelle D. J., Crissman J. D., Shumrick D. A. Tonsillar carcinoma – treatment results. Laryngoscope 1979;89:1842–6.31. LaFerriere K. A., Sessions D. G., Thawley S. E. et al. Composite resection andreconstruction for oral cavity and oropharynx cancer. A functional approach. Arch Otolaryngol 1980;106:103–10.LaFerriere K. A., Sessions D. G., Thawley S. E. et al. Composite resection andreconstruction for oral cavity and oropharynx cancer. A functional approach. Arch Otolaryngol 1980;106:103–10.32. Spiessl B., Tschopp H.M. Surgery of the jaws in head and neck surgery, face, and facial skull. In: Naumann H.H., ed. Head and Neck Surgery. Vol. 2. Philadelphia: WB Saunders, 1980. Pр. 149–154.Spiessl B., Tschopp H.M. Surgery of the jaws in head and neck surgery, face, and facial skull. In: Naumann H.H., ed. Head and Neck Surgery. Vol. 2. Philadelphia: WB Saunders, 1980. Pр. 149–154.33. Ariyan S. One-stage reconstruction for defects of the mouth using a sternomastoid myocutaneus flap. Plast Reconstr Surg 1979;63:618–25.Ariyan S. One-stage reconstruction for defects of the mouth using a sternomastoid myocutaneus flap. Plast Reconstr Surg 1979;63:618–25.