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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">318</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2018-8-1-12-16</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Locally advanced cancer of the tongue base: new method of surgical treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Способ лечения местно-распространенного рака корня языка</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0183-4827</contrib-id><name-alternatives><name xml:lang="en"><surname>Zaderenko</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Задеренко</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><email>igorakis@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0918-3857</contrib-id><name-alternatives><name xml:lang="en"><surname>Mudunov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Мудунов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ivanov</surname><given-names>S. Yu.</given-names></name><name xml:lang="ru"><surname>Иванов</surname><given-names>С. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>10 Miklukho-Maklaya St., Moscow 117198.</p></bio><bio xml:lang="ru"><p>117198 Москва, ул. Миклухо-Маклая, 10.</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Azizyan</surname><given-names>R. I.</given-names></name><name xml:lang="ru"><surname>Азизян</surname><given-names>Р. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9543-990X</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhundov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Ахундов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6835-5567</contrib-id><name-alternatives><name xml:lang="en"><surname>Alieva</surname><given-names>S. B.</given-names></name><name xml:lang="ru"><surname>Алиева</surname><given-names>С. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3090-695X</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsiklauri</surname><given-names>V. T.</given-names></name><name xml:lang="ru"><surname>Циклаури</surname><given-names>В. Т.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Narimanov</surname><given-names>M. N.</given-names></name><name xml:lang="ru"><surname>Нариманов</surname><given-names>М. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7117-9453</contrib-id><name-alternatives><name xml:lang="en"><surname>Kazimov</surname><given-names>A. E.</given-names></name><name xml:lang="ru"><surname>Казимов</surname><given-names>А. Э.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6225-663X</contrib-id><name-alternatives><name xml:lang="en"><surname>Il’kaev</surname><given-names>K. D.</given-names></name><name xml:lang="ru"><surname>Илькаев</surname><given-names>К. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478.</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1673-7261</contrib-id><name-alternatives><name xml:lang="en"><surname>Khromushina</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Хромушина</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>10 Miklukho-Maklaya St., Moscow 117198.</p></bio><bio xml:lang="ru"><p>117198 Москва, ул. Миклухо-Маклая, 10.</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Department of Maxillo-Facial Surgery and Operative Dentistry, RUDN University.</institution></aff><aff><institution xml:lang="ru">Кафедра челюстно-лицевой хирургии и хирургической стоматологии ФГАОУ ВО «Российский университет дружбы народов».</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-04-12" publication-format="electronic"><day>12</day><month>04</month><year>2018</year></pub-date><volume>8</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>12</fpage><lpage>16</lpage><history><date date-type="received" iso-8601-date="2018-04-12"><day>12</day><month>04</month><year>2018</year></date><date date-type="accepted" iso-8601-date="2018-04-12"><day>12</day><month>04</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Zaderenko I.A., Mudunov A.M., Ivanov S.Y., Azizyan R.I., Akhundov A.A., Alieva S.B., Tsiklauri V.T., Narimanov M.N., Kazimov A.E., Il’kaev K.D., Khromushina A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Задеренко И.А., Мудунов А.М., Иванов С.Ю., Азизян Р.И., Ахундов А.А., Алиева С.Б., Циклаури В.Т., Нариманов М.Н., Казимов А.Э., Илькаев К.Д., Хромушина А.В.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Zaderenko I.A., Mudunov A.M., Ivanov S.Y., Azizyan R.I., Akhundov A.A., Alieva S.B., Tsiklauri V.T., Narimanov M.N., Kazimov A.E., Il’kaev K.D., Khromushina A.V.</copyright-holder><copyright-holder xml:lang="ru">Задеренко И.А., Мудунов А.М., Иванов С.Ю., Азизян Р.И., Ахундов А.А., Алиева С.Б., Циклаури В.Т., Нариманов М.Н., Казимов А.Э., Илькаев К.Д., Хромушина А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/318">https://ogsh.abvpress.ru/jour/article/view/318</self-uri><abstract xml:lang="en"><p><bold>Introduction.</bold> Patients are characterized by locally advanced tumors in 70–80 % of cases at presentation, so possibility of cure and surgical treatment is limited. Total glossectomy, tongue base resection is associated with severe and permanent disability. Such surgical procedures lead to severe dysphagia, alalia and social maladjustment. Enumerated issues motivated us to develop new method of surgical treatment  of locally advanced base of tongue cancer.</p><p><bold>Objective</bold> is to introduce new opportunities of surgical treatment of locally advanced cancer of the tongue base.</p><p><bold>Materials and methods</bold>. Glossectomy is accomplished in 5 patients suffering from tongue cancer and admitted to N.N. Blokhin National Medical Research Center of Oncology. Swallowing and speech is preserved in all 5 cases.</p><p><bold>Results.</bold> The main advantage of the proposed method is that the cut out muscle flap has a different innervation from different cranial nerves involved in the rate of swallowing, so there is not just a mechanical movement of the epiglottis, but also the control of swallowing by the central nervous system. The reduction of injury and operation time in the proposed method is due to the fact that tissues directly contacting with the defect are used to preserve swallowing and speech. The proposed muscle flap has various sources of blood supply, which improves its nutrition and reduces the risk of complications, and healing occurs in a shorter time in comparison with the prototype. All of the above reduces the duration of hospitalization for an average of 7–9 days.</p><p><bold>Conclusion</bold>. The developed surgical technique allows to achieve early rehabilitation; patients are able to breathe effortlessly, swallow and speak. There is no need in permanent tracheostoma and percutaneous endoscopic gastrostomy tube. All patients remains socially active. </p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение.</bold> У 70–80 % больных с местно-распространенными опухолями орофарингеальной области возможности излечения с помощью хирургических методов ограниченны. Тотальное удаление языка, удаление корня языка ведет к тяжелой стойкой инвалидизации пациентов. У таких пациентов нарушены или полностью отсутствуют функции глотания, речи. Перечисленные проблемы побудили нас разработать новый способ хирургического лечения данного заболевания.</p><p><bold> Цель исследования</bold> – представить новый способ хирургического лечения местно-распространенного рака корня языка.</p><p><bold>Материалы и методы.</bold> В отделении опухолей верхних дыхательных и пищеварительных путей ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России у 5 больных с тотальным поражением языка проведена глоссэктомия с сохранением функций глотания и речи.</p><p><bold> Результаты.</bold> Основное преимущество предлагаемого способа заключается в том, что выкраиваемый мышечный лоскут имеет различную иннервацию из разных черепных нервов, участвующих в норме в глотании, поэтому происходит не просто механическое движение надгортанника, но и контроль глотания центральной нервной системой. Сокращение травматичности и времени операции обусловлено тем, что для сохранения глотания и речи используются ткани, непосредственно контактирующие с дефектом. Предлагаемый мышечный лоскут имеет различные источники кровоснабжения, что улучшает его питание и снижает риск осложнений, и заживление происходит в более короткие сроки по сравнению с прототипом. Все вышеперечисленное сокращает время пребывания в стационаре в среднем на 7–9 дней.</p><p><bold>Выводы</bold>. Применение разработанного нами нового способа хирургического лечения местно-распространенного рака корня позволяет провести раннюю реабилитацию, пациенты могут свободно дышать, глотать, общаться. Они не нуждаются в постоянной трахеостоме, гастростоме, социально реабилитированы. </p></trans-abstract><kwd-group xml:lang="en"><kwd>locally advanced cancer of the tongue base</kwd><kwd>glossectomy</kwd><kwd>surgical treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>местно-распространенный рак корня языка</kwd><kwd>глоссэктомия</kwd><kwd>хирургическое лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Barnes L., Eveson J.W., Reichart P., Sidransky D. World Health Organization classification of tumors. Pathology and genetics of head and neck tumors. 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