Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press3210.17650/2222-1468-2014-0-2-10-13ORIGINAL REPORTSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯCONTROVERSIAL ISSUES IN THE TREATMENT OF PATIENTS WITH T3N0–2M0 LARYNGEAL FOLD CANCERСПОРНЫЕ ВОПРОСЫ В ЛЕЧЕНИИ БОЛЬНЫХ РАКОМ СКЛАДОЧНОГО ОТДЕЛА ГОРТАНИ T3N0–2M0TaneevaA. Sh.ТанееваА. Ш.
Russian Federation
alityaliya@mail.ruMudunovA. M.МудуновА. М.
Russian Federation
alityaliya@mail.ruAlievaS. B.АлиеваС. Б.
Russian Federation
alityaliya@mail.ruN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowНИИ клинической онкологии ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowОтделение радиационной онкологии ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва150420144210131604201516042015Copyright ©; 2014, Taneeva A.S., Mudunov A.M., Alieva S.B.Copyright ©; 2014, Танеева А.Ш., Мудунов А.М., Алиева С.Б.2014Taneeva A.S., Mudunov A.M., Alieva S.B.Танеева А.Ш., Мудунов А.М., Алиева С.Б.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/32

The paper gives the results of surgical, combined, and chemoradiation treatments in 102 patients with laryngeal fold cancer of the extent corresponding to T3N0–2M0, who have been treated at the Department for Surgery of Upper Respiratory and Digestive Tracts, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences. It discusses the influence of different prognostic factors on survival, as well as recommendations to determine the most optimal treatment policy in this category of patients.

В статье представлены результаты хирургического, комбинированного и химиолучевого лечения 102 больных раком складочного отдела гортани с распространенностью, соответствующей T3N0–2M0, пролеченных в хирургическом отделении опухолей верхних дыхательных и пищеварительных путей ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН. Обсуждаются влияние различных факторов прогноза на выживаемость и рекомендации по определению наиболее оптимальной тактики лечения у данной категории больных.

laryngeal cancerT3treatmentprognostic factorsрак гортаниТ3лечениефакторы прогноза1. Mantsopoulos K., Psychogios G., Bohr C. et al. Primary surgical treatment of T3 glottic carcinoma: long-term results and decision-making aspects. Laryngoscope 2012;122:2723–7.Mantsopoulos K., Psychogios G., Bohr C. et al. Primary surgical treatment of T3 glottic carcinoma: long-term results and decision-making aspects. Laryngoscope 2012;122:2723–7.2. Ganly I., Patel S.G., Matsuo J. et al. Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck 2009;31:1489–95.Ganly I., Patel S.G., Matsuo J. et al. Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck 2009;31:1489–95.3. Nguyen-Tan P.F., Le Q.T., Quivey J.M. et al. Treatment results and prognostic factors of advanced T3–4 laryngeal carcinoma: the University of California, SanNguyen-Tan P.F., Le Q.T., Quivey J.M. et al. Treatment results and prognostic factors of advanced T3–4 laryngeal carcinoma: the University of California, SanFrancisco (UCSF) and Stanford University Hospital (SUH) experience. Int J Radiat Oncol Biol Phys 2001;50: 1172–80.4. Lassaletta L., Garcia-Pallares M., Morera E. et al. T3 glottic cancer: oncologic results and prognostic factors. Otolaryngol Head Neck Surg 2001;124:556–60.Lassaletta L., Garcia-Pallares M., Morera E. et al. T3 glottic cancer: oncologic results and prognostic factors. Otolaryngol Head Neck Surg 2001;124:556–60.5. Nikolaou A., Markou K., Petridis D. et al. Factors influencing tumor relapse after total laryngectomy. B-ENT 2005;1:1–10.Nikolaou A., Markou K., Petridis D. et al. Factors influencing tumor relapse after total laryngectomy. B-ENT 2005;1:1–10.6. Kowalski L.P., Batista M.B., Santos C.R. et al. Prognostic factors in T3, N0–1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy. Arch Otolaryngol Head Neck Surg 1996;122:77–82.Kowalski L.P., Batista M.B., Santos C.R. et al. Prognostic factors in T3, N0–1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy. Arch Otolaryngol Head Neck Surg 1996;122:77–82.7. Richard J.M., Sancho-Garnier H., Pessey J.J. et al. Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol 1998;34:224–8.Richard J.M., Sancho-Garnier H., Pessey J.J. et al. Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol 1998;34:224–8.8. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med 1991;324:1685–90.Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med 1991;324:1685–90.9. Forastiere A.A., Goepfert H., Maor M. et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091–8.Forastiere A.A., Goepfert H., Maor M. et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091–8.10. Forastiere A.A., Zhang Q., Weber R.S. et al. Long-term results of RTOG 91–11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 2013;31:845–52.Forastiere A.A., Zhang Q., Weber R.S. et al. Long-term results of RTOG 91–11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 2013;31:845–52.11. Клинические рекомендации по лечению опухолей головы и шеи Общенациональной онкологической сети (США), National Comprehensive Cancer Network (NCCN), 2011.Клинические рекомендации по лечению опухолей головы и шеи Общенациональной онкологической сети (США), National Comprehensive Cancer Network (NCCN), 2011.12. Lefebvre J.L., Pointreau Y., Rolland F. et al. Induction Chemotherapy Followed by Either Chemoradiotherapy or Bioradiotherapy for Larynx Preservation: the TREMPLIN Randomized PHASE II Study. J Clin Oncol 2013;31:853–9.Lefebvre J.L., Pointreau Y., Rolland F. et al. Induction Chemotherapy Followed by Either Chemoradiotherapy or Bioradiotherapy for Larynx Preservation: the TREMPLIN Randomized PHASE II Study. J Clin Oncol 2013;31:853–9.13. Argiris A., Ghebremichael M., Gilbert J. et al. Phase III randomized, placebocontrolled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol 2013;31:1405–14.Argiris A., Ghebremichael M., Gilbert J. et al. Phase III randomized, placebocontrolled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol 2013;31:1405–14.14. Basheeth N., O’Leary G., Khan H., Sheahan P. Oncologic outcomes of total laryngectomy: impact of margins and preoperative tracheostomy. Head Neck 2014 Mar 12.Basheeth N., O’Leary G., Khan H., Sheahan P. Oncologic outcomes of total laryngectomy: impact of margins and preoperative tracheostomy. Head Neck 2014 Mar 12.15. Chen S.W., Yang S.N., Liang J.A. et al. Prognostic impact of tumor volume in patients with stage III–IVA hypopharyngeal cancer without bulcy lymph nodes treated with definitive concurrent chemoradiotherapy. Head Neck 2009 Jun;31(6):709–16.Chen S.W., Yang S.N., Liang J.A. et al. Prognostic impact of tumor volume in patients with stage III–IVA hypopharyngeal cancer without bulcy lymph nodes treated with definitive concurrent chemoradiotherapy. Head Neck 2009 Jun;31(6):709–16.