Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press34810.17650/2222-1468-2018-8-2-62-67REVIEWОБЗОРНАЯ СТАТЬЯSurgical management of locally advanced thyroid cancer (narrative review)Хирургическое лечение местно-распространенного рака щитовидной железы (обзор литературы)https://orcid.org/0000-0002-6895-0497RadzhabovaZ. A.-G.РаджабоваЗ. А.-Г.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg, 197758

197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

radzam@mail.ruhttps://orcid.org/0000-0002-2586-1240KotovM. A.КотовМ. А.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg, 197758

197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

radzam@mail.ruhttps://orcid.org/0000-0002-7223-3634ArtemievS. S.АртемьевС. С.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg, 197758

197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

radzam@mail.ruRadzhabovaM. A.РаджабоваМ. А.
Russian Federation

6 Akademica Lebedeva St., Saint Petersburg, 194044

194044 Санкт-Петербург,  ул. Академика Лебедева, 6

radzam@mail.ruN.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia.ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова» Минздрава России.S.M. Kirov Military Medical Academy, Ministry of Defense of Russia.ФГБВОУ ВО «Военно-медицинская академия им. С. М. Кирова» Минобороны России.060720188262670707201807072018Copyright ©; 2018, Radzhabova Z.A., Kotov M.A., Artemiev S.S., Radzhabova M.A.Copyright ©; 2018, Раджабова З.А., Котов М.А., Артемьев С.С., Раджабова М.А.2018Radzhabova Z.A., Kotov M.A., Artemiev S.S., Radzhabova M.A.Раджабова З.А., Котов М.А., Артемьев С.С., Раджабова М.А.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/348

A review of the literature on the problem of surgical treatment of local invasive thyroid cancer with damage to surrounding structures is presented. The comparative characteristics of various surgical tactics for the invasion of highly differentiated thyroid cancer into recurrent guttural nerves, larynx and trachea, esophagus have been performed. The advantage of intraoperative neuromonitoring was shown when deciding whether to retain the recurrent laryngeal nerve in the presence of invasion. The systems of staging of laryngotracheal invasion depending on the degree of its spread and surgical tactics used for each degree of laryngotracheal invasion are considered.

Проанализированы данные научной литературы по проблеме хирургического лечения локального инвазивного рака щитовидной железы с  поражением окружающих структур. Проведена сравнительная характеристика различных хирургических тактик при инвазии высокодифференцированного рака щитовидной железы в мышцы шеи, возвратные гортанные нервы, гортань, трахею, пищевод. Показано преимущество использования интраоперационного нейромониторинга при принятии решения о сохранении возвратного гортанного нерва при наличии инвазии. Рассмотрены классификации ларинготрахеальной инвазии в зависимости от степени ее распространения и хирургическая тактика, применяемая при каждой стадии.

locally invasive thyroid cancersurgeryinvasionместно-распространенный рак щитовидной железыхирургическое лечениеинвазия1. Andersen P. E., Kinsella J., Loree T. R. et al. Differentiated carcinoma of the thyroid with extrathyroidal extension. Am J Surg 1995;170(5):467–70 PMID: 7485734.Andersen P. E., Kinsella J., Loree T. R. et al. Differentiated carcinoma of the thyroid with extrathyroidal extension. Am J Surg 1995;170(5):467–70 PMID: 7485734.2. Hay I. D., McConahey W. M., Goellner J. R. Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic’s experienceof treating 2,512 consecutive patients during 1940 through 2000. Trans Am ClinClimatol Assoc 2002;113:241–60. PMID: 12053713.Hay I. D., McConahey W. M., Goellner J. R. Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic’s experienceof treating 2,512 consecutive patients during 1940 through 2000. Trans Am ClinClimatol Assoc 2002;113:241–60. PMID: 12053713.3. McCaffrey T. V., Bergstralh E. J., Hay I. D. Locally invasive papillary thyroidcarcinoma: 1940–1990. Head Neck 1994;16(2):165–72. PMID: 8021137.McCaffrey T. V., Bergstralh E. J., Hay I. D. Locally invasive papillary thyroidcarcinoma: 1940–1990. Head Neck 1994;16(2):165–72. PMID: 8021137.4. Machens A., Hinze R., Lautenschlager C.et al. Thyroid carcinoma invading the cervicovisceral axis: routes of invasionand clinical implications. Surgery 2001;129(1):23–8. PMID: 11150030.Machens A., Hinze R., Lautenschlager C.et al. Thyroid carcinoma invading the cervicovisceral axis: routes of invasionand clinical implications. Surgery 2001;129(1):23–8. PMID: 11150030.5. McCaffrey T. V., Lipton R. J. Thyroid carcinoma invading the upper aerodigestive system. Laryngoscope 1990;100(8):824–30. DOI: 10.1288/00005537-199008000-00006. PMID: 2381258.McCaffrey T. V., Lipton R. J. Thyroid carcinoma invading the upper aerodigestive system. Laryngoscope 1990;100(8):824–30. DOI: 10.1288/00005537-199008000-00006. PMID: 2381258.6. Lawson W., Som H. L., Biller H. F. Papillary adenocarcinoma of the thyroid invading the upper air passages. Ann Otol Rhinol Laryngol 1977;86(6 Pt 1):751–5. DOI: 10.1177/000348947708600606. PMID: 596772.Lawson W., Som H. L., Biller H. F. Papillary adenocarcinoma of the thyroid invading the upper air passages. Ann Otol Rhinol Laryngol 1977;86(6 Pt 1):751–5. DOI: 10.1177/000348947708600606. PMID: 596772.7. Breaux G. P. Jr, Guillamondegui O. M. Treatment of locally invasive carcinoma of the thyroid: how radical? Am J Surg 1980;140(4):514–7. PMID: 7425234.Breaux G. P. Jr, Guillamondegui O. M. Treatment of locally invasive carcinoma of the thyroid: how radical? Am J Surg 1980;140(4):514–7. PMID: 7425234.8. Cody H. S. 3rd, Shah J. P. Locally invasive, well differentiated thyroid cancer. 22 years’ experience at Memorial Sloan-Kettering Cancer Center. Am J Surg 1981;142(4):480–3. PMID: 7283051.Cody H. S. 3rd, Shah J. P. Locally invasive, well differentiated thyroid cancer. 22 years’ experience at Memorial Sloan-Kettering Cancer Center. Am J Surg 1981;142(4):480–3. PMID: 7283051.9. Friedman M., Danielzadeh J. A., Caldarelli D. D. Treatment of patients with carcinoma of the thyroid invading the airway. Arch Otolaryngol Head Neck Surg 1994;120(12):1377–81. PMID: 7980904.Friedman M., Danielzadeh J. A., Caldarelli D. D. Treatment of patients with carcinoma of the thyroid invading the airway. Arch Otolaryngol Head Neck Surg 1994;120(12):1377–81. PMID: 7980904.10. Grillo H. C., Zannini P. Resectional management of airway invasion by thyroid carcinoma. Ann Thorac Surg 1986;42(3):287–98. PMID: 3753077.Grillo H. C., Zannini P. Resectional management of airway invasion by thyroid carcinoma. Ann Thorac Surg 1986;42(3):287–98. PMID: 3753077.11. Randolph G. W., Kamani D. The importance of preoperative laryngoscopy in patients undergoing thyroidectomy: voice, vocal cord function, and the detection of invasive thyroid malignancy. Surgery 2006;139(3):357–62. DOI: 10.1016/j.surg.2005.08.009. PMID: 16546500.Randolph G. W., Kamani D. The importance of preoperative laryngoscopy in patients undergoing thyroidectomy: voice, vocal cord function, and the detection of invasive thyroid malignancy. Surgery 2006;139(3):357–62. DOI: 10.1016/j.surg.2005.08.009. PMID: 16546500.12. Chiang F. Y., Wang L. F., Huang Y. F. et al. Recurrent laryngeal nerve palsy after thyroidectomy with routine identification of the recurrent laryngeal nerve. Surgery 2005;137(3):342–7. DOI: 10.1016/j.surg.2004.09.008. PMID: 15746790.Chiang F. Y., Wang L. F., Huang Y. F. et al. Recurrent laryngeal nerve palsy after thyroidectomy with routine identification of the recurrent laryngeal nerve. Surgery 2005;137(3):342–7. DOI: 10.1016/j.surg.2004.09.008. PMID: 15746790.13. Falk S. A., McCaffrey T. V. Management of the recurrent laryngeal nerve in suspected and proven thyroid cancer. Otolaryngol Head Neck Surg 1995;113(1):42–8. DOI: 10.1016/S0194-59989570143-5. PMID: 7603720.Falk S. A., McCaffrey T. V. Management of the recurrent laryngeal nerve in suspected and proven thyroid cancer. Otolaryngol Head Neck Surg 1995;113(1):42–8. DOI: 10.1016/S0194-59989570143-5. PMID: 7603720.14. Nishida T., Nakao K., Hamaji M. et al. Preservation of recurrent laryngeal nerve invaded by differentiated thyroid cancer. Ann Surg 1997;226(1):85–91. PMID: 9242342.Nishida T., Nakao K., Hamaji M. et al. Preservation of recurrent laryngeal nerve invaded by differentiated thyroid cancer. Ann Surg 1997;226(1):85–91. PMID: 9242342.15. Price D. L., Wong R. J., Randolph G. W. Invasive thyroid cancer: management of the trachea and esophagus. Otolaryngol Clin North Am 2008;41(6):1155–68. DOI: 10.1016/j.otc.2008.08.002. PMID: 19040976.Price D. L., Wong R. J., Randolph G. W. Invasive thyroid cancer: management of the trachea and esophagus. Otolaryngol Clin North Am 2008;41(6):1155–68. DOI: 10.1016/j.otc.2008.08.002. PMID: 19040976.16. Kim K. H., Sung M. W., Chang K. H., Kang B. S. Therapeutic dilemmas in the management of thyroid cancer with laryngotracheal involvement. Otolaryngol Head Neck Surg 2000;122(5):763–7. DOI: 10.1016/S0194–5998(00) 70212–9. PMID: 10793362.Kim K. H., Sung M. W., Chang K. H., Kang B. S. Therapeutic dilemmas in the management of thyroid cancer with laryngotracheal involvement. Otolaryngol Head Neck Surg 2000;122(5):763–7. DOI: 10.1016/S0194–5998(00) 70212–9. PMID: 10793362.17. Yumoto E., Sanuki T., Kumai Y. Immediate recurrent laryngeal nerve reconstruction and vocal outcome. Laryngoscope 2006;116(9):1657–61. DOI: 10.1097/01.mlg.0000233245.27582.fc. PMID: 16954999.Yumoto E., Sanuki T., Kumai Y. Immediate recurrent laryngeal nerve reconstruction and vocal outcome. Laryngoscope 2006;116(9):1657–61. DOI: 10.1097/01.mlg.0000233245.27582.fc. PMID: 16954999.18. Chan W. F., Lang B. H., Lo C. Y. The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk. Surgery 2006;140(6):866–72. DOI: 10.1016/j.surg.2006.07.017. PMID: 17188132.Chan W. F., Lang B. H., Lo C. Y. The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk. Surgery 2006;140(6):866–72. DOI: 10.1016/j.surg.2006.07.017. PMID: 17188132.19. Dralle H., Sekulla C., Haerting J. et al. Risk factors of paralysis and functional outcome after recurrent laryngeal nerve monitoring in thyroid surgery. Surgery 2004;136(6):1310–22. DOI: 10.1016/j.surg.2004.07.018. PMID: 15657592.Dralle H., Sekulla C., Haerting J. et al. Risk factors of paralysis and functional outcome after recurrent laryngeal nerve monitoring in thyroid surgery. Surgery 2004;136(6):1310–22. DOI: 10.1016/j.surg.2004.07.018. PMID: 15657592.20. Robertson M. L., Steward D. L., Gluckman J. L., Welge J. Continuous laryngeal nerve integrity monitoring during thyroidectomy: does it reduce risk of injury? Otolaryngol Head Neck Surg 2004;131(5):596–600. DOI: 10.1016/j.otohns.2004.05.030. PMID: 15523432.Robertson M. L., Steward D. L., Gluckman J. L., Welge J. Continuous laryngeal nerve integrity monitoring during thyroidectomy: does it reduce risk of injury? Otolaryngol Head Neck Surg 2004;131(5):596–600. DOI: 10.1016/j.otohns.2004.05.030. PMID: 15523432.21. Shindo M., Chheda N. N. Incidence of vocal cord paralysis with and without recurrent laryngeal nerve monitoring during thyroidectomy. Arch Otolaryngol Head Neck Surg 2007;133(5):481–5. DOI: 10.1001/archotol.133.5.481. PMID: 17520762.Shindo M., Chheda N. N. Incidence of vocal cord paralysis with and without recurrent laryngeal nerve monitoring during thyroidectomy. Arch Otolaryngol Head Neck Surg 2007;133(5):481–5. DOI: 10.1001/archotol.133.5.481. PMID: 17520762.22. Czaja J. M., McCaffrey T. V. The surgical management of laryngotracheal invasion by well differentiated papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 1997;123(5):484–90. PMID: 9158394.Czaja J. M., McCaffrey T. V. The surgical management of laryngotracheal invasion by well differentiated papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 1997;123(5):484–90. PMID: 9158394.23. McCaffrey J. C. Aerodigestive tract invasion by well differentiated thyroid carcinoma: diagnosis, management, prognosis, and biology. Laryngoscope 2006;116(1):1–11. DOI: 10.1097/01.MLG.0000200428.26975.86. PMID: 16481800.McCaffrey J. C. Aerodigestive tract invasion by well differentiated thyroid carcinoma: diagnosis, management, prognosis, and biology. Laryngoscope 2006;116(1):1–11. DOI: 10.1097/01.MLG.0000200428.26975.86. PMID: 16481800.24. Shin D. H., Mark E. J., Suen H. C., Grillo H. C. Pathologic staging of papillary carcinoma of the thyroid with airway invasion based on the anatomic manner of extension to the trachea: a clinico-pathologic study based on 22 patients who underwent thyroidectomy and airway resection. Hum Pathol 1993;24(8):866–70. PMID: 8375857.Shin D. H., Mark E. J., Suen H. C., Grillo H. C. Pathologic staging of papillary carcinoma of the thyroid with airway invasion based on the anatomic manner of extension to the trachea: a clinico-pathologic study based on 22 patients who underwent thyroidectomy and airway resection. Hum Pathol 1993;24(8):866–70. PMID: 8375857.25. McCaffrey J. C. Evaluation and treatment of aerodigestive tract invasion by well differentiated thyroid carcinoma. Cancer Control 2000;7(3):246–52. DOI: 10.1177/107327480000700304. PMID: 10832111.McCaffrey J. C. Evaluation and treatment of aerodigestive tract invasion by well differentiated thyroid carcinoma. Cancer Control 2000;7(3):246–52. DOI: 10.1177/107327480000700304. PMID: 10832111.26. Segal K., Shpitzer T., Hazan A. et al. Invasive well differentiated thyroid carcinoma: effect of treatment modalities on outcome. Otolaryngol Head Neck Surg 2006;134(5):819–22. DOI: 10.1016/j.otohns.2005.11.040. PMID: 16647541.Segal K., Shpitzer T., Hazan A. et al. Invasive well differentiated thyroid carcinoma: effect of treatment modalities on outcome. Otolaryngol Head Neck Surg 2006;134(5):819–22. DOI: 10.1016/j.otohns.2005.11.040. PMID: 16647541.27. Park C. S., Suh K. W., Min J. S. Cartilage-shaving procedure for the control of tracheal cartilage invasion by thyroid carcinoma. Head Neck 1993;15(4):289–91. PMID: 8360048.Park C. S., Suh K. W., Min J. S. Cartilage-shaving procedure for the control of tracheal cartilage invasion by thyroid carcinoma. Head Neck 1993;15(4):289–91. PMID: 8360048.28. Kasperbauer J. L. Locally advanced thyroid carcinoma. Ann Otol Rhinol Laryngol 2004;113(9):749–53. DOI: 10.1177/000348940411300914. PMID: 15453535.Kasperbauer J. L. Locally advanced thyroid carcinoma. Ann Otol Rhinol Laryngol 2004;113(9):749–53. DOI: 10.1177/000348940411300914. PMID: 15453535.29. Gaissert H. A., Honings J., Grillo H. C. et al. Segmental laryngotracheal and tracheal resection for invasive thyroid carcinoma. Ann Thorac Surg 2007;83(6):1952–9. DOI: 10.1016/j.athoracsur.2007.01.056. PMID: 17532377.Gaissert H. A., Honings J., Grillo H. C. et al. Segmental laryngotracheal and tracheal resection for invasive thyroid carcinoma. Ann Thorac Surg 2007;83(6):1952–9. DOI: 10.1016/j.athoracsur.2007.01.056. PMID: 17532377.30. Wada N., Nakayama H., Masudo Y. et al. Clinical outcome of different modes of resection in papillary thyroid carcinomas with laryngotracheal invasion. Langenbecks Arch Surg 2006;391(6):545–9. DOI: 10.1007/s00423-006-0106-9. PMID: 17043903.Wada N., Nakayama H., Masudo Y. et al. Clinical outcome of different modes of resection in papillary thyroid carcinomas with laryngotracheal invasion. Langenbecks Arch Surg 2006;391(6):545–9. DOI: 10.1007/s00423-006-0106-9. PMID: 17043903.31. Nishida T., Nakao K., Hamaji M. Differentiated thyroid carcinoma with airway invasion: indication for tracheal resection based on the extent of cancer invasion. J Thorac Cardiovasc Surg 1997;114(1):84–92. DOI: 10.1016/S0022-5223(97)70120-X. PMID: 9240297.Nishida T., Nakao K., Hamaji M. Differentiated thyroid carcinoma with airway invasion: indication for tracheal resection based on the extent of cancer invasion. J Thorac Cardiovasc Surg 1997;114(1):84–92. DOI: 10.1016/S0022-5223(97)70120-X. PMID: 9240297.32. Grillo H. C. Tracheal blood supply. Ann Thorac Surg 1977;24(2):99. PMID: 879905.Grillo H. C. Tracheal blood supply. Ann Thorac Surg 1977;24(2):99. PMID: 879905.33. Grillo H. C., Suen H. C., Mathisen D. J., Wain J. C. Resectional management of thyroid carcinoma invading the airway. Ann Thorac Surg 1992;54(1):3–9. PMID: 1610250.Grillo H. C., Suen H. C., Mathisen D. J., Wain J. C. Resectional management of thyroid carcinoma invading the airway. Ann Thorac Surg 1992;54(1):3–9. PMID: 1610250.34. Tsutsui H., Usuda J., Kubota M. et al. Endoscopic tumor ablation for laryngo-tracheal intraluminal invasion secondary to advanced thyroid cancer. Acta Oto laryngol 2008;128(7):799–807. DOI: 10.1080/00016480701714285. PMID: 18568524.Tsutsui H., Usuda J., Kubota M. et al. Endoscopic tumor ablation for laryngo-tracheal intraluminal invasion secondary to advanced thyroid cancer. Acta Oto laryngol 2008;128(7):799–807. DOI: 10.1080/00016480701714285. PMID: 18568524.35. Donnelly M. J., Timon C. I., McShane D. P. The role of total laryngectomy in the management of intraluminal upper airway invasion by well differentiated thyroid carcinoma. Ear Nose Throat J 1994;73(9):659–62. PMID: 7988395.Donnelly M. J., Timon C. I., McShane D. P. The role of total laryngectomy in the management of intraluminal upper airway invasion by well differentiated thyroid carcinoma. Ear Nose Throat J 1994;73(9):659–62. PMID: 7988395.36. Ginsberg G. G. Palliation of malignant esophageal dysphagia: would you like plastic or metal? Am J Gastroenterol 2007;102(12):2678–9. DOI: 10.1111/j.1572-0241.2007.01557.x. PMID: 18042103.Ginsberg G. G. Palliation of malignant esophageal dysphagia: would you like plastic or metal? Am J Gastroenterol 2007;102(12):2678–9. DOI: 10.1111/j.1572-0241.2007.01557.x. PMID: 18042103.