Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press36410.17650/2222-1468-2018-8-3-77-83REVIEWОБЗОРНАЯ СТАТЬЯHuman papillomavirus-associated oropharyngeal carcinoma: trends in epidemiology and methods for detecting the virus in tumorsОрофарингеальная карцинома, ассоциированная с вирусом папилломы человека: тенденции эпидемиологии и методы выявления вируса в опухолиhttps://orcid.org/0000-0002-0698-7710Stukan'A. I.СтуканьА. И.
Russian Federation

146 Dimitrova St., Krasnodar 350040;

4 Mitrofana Sedina St., Krasnodar 350063.

350040 Краснодар, ул. Димитрова, 146;

350063 Краснодар, ул. Митрофана Седина, 4.

jolie86@bk.ruChukhrayO. Yu.ЧухрайО. Ю.
Russian Federation

146 Dimitrova St., Krasnodar 350040.

350040 Краснодар, ул. Димитрова, 146.

https://orcid.org/0000-0003-0572-1395PorkhanovV. A.ПорхановВ. А.
Russian Federation

4 Mitrofana Sedina St., Krasnodar 350063;

167 1 Maya St., Krasnodar 350086.

350063 Краснодар, ул. Митрофана Седина, 4;

350086 Краснодар, ул. 1 Мая, 167.

MurashkoR. A.МурашкоР. А.
Russian Federation

146 Dimitrova St., Krasnodar 350040;

4 Mitrofana Sedina St., Krasnodar 350063.

350040 Краснодар, ул. Димитрова, 146;

350063 Краснодар, ул. Митрофана Седина, 4.

https://orcid.org/0000-0003-3169-9558BodnyaV. N.БодняВ. H.
Russian Federation

4 Mitrofana Sedina St., Krasnodar 350063;

167 1 Maya St., Krasnodar 350086.

350063 Краснодар, ул. Митрофана Седина, 4;

350086 Краснодар, ул. 1 Мая, 167.

MakarovaYu. M.МакароваЮ. М.
Russian Federation

146 Dimitrova St., Krasnodar 350040.

350040 Краснодар, ул. Димитрова, 146.

Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar RegionГБУЗ «Клинический онкологический диспансер № 1» министерства здравоохранения Краснодарского краяKuban State Medical University, Ministry of Health of Russia.ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России.Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar Region.ГБУЗ «Клинический онкологический диспансер № 1» министерства здравоохранения Краснодарского края.Kuban State Medical University, Ministry of Health of RussiaФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава РоссииScientific Research Institute – S. V. Ochapovsky Regional Clinical Hospital No. 1, Ministry of Health of the Krasnodar Region.ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница № 1 им. С. В. Очаповского» министерства здравоохранения Краснодарского края.081120188377830711201807112018Copyright ©; 2018, Stukan' A.I., Chukhray O.Y., Porkhanov V.A., Murashko R.A., Bodnya V.N., Makarova Y.M.Copyright ©; 2018, Стукань А.И., Чухрай О.Ю., Порханов В.А., Мурашко Р.А., Бодня В.H., Макарова Ю.М.2018Stukan' A.I., Chukhray O.Y., Porkhanov V.A., Murashko R.A., Bodnya V.N., Makarova Y.M.Стукань А.И., Чухрай О.Ю., Порханов В.А., Мурашко Р.А., Бодня В.H., Макарова Ю.М.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/364

Oropharyngeal squamous cell carcinoma has been traditionally associated with tobacco and alcohol consumption. Nevertheless, latter 30 years have shown squamous cell carcinoma (OPSCC) incidence stagnation and increasing, despite the decrease in smoking prevalence. The incidence was recognized among white men of middle age, often non-smokers or former smokers in the investigations with smoking cessation data. It differs from traditional patient with OPSCC, older men, heavy smoker or alcohol drinker. The incidence of OPSCC is increased due human papilloma virus (HPV) infection. The infection transition is associated with sex and oro-genital contact may lead to HPV-infection of oropharynx and oral cavity. There are multiple types of HPV, but the majority of OPSCC is associated with HPV 16 type. Epidemiology of HPV-associated OPSCC, HPV-infection of oral cavity and/or oropharynx and HPV detection are discussed in the review.

Возникновение орофарингеальной плоскоклеточной карциномы (ОФПКК) традиционно связывают с воздействием табачного дыма и алкоголя. Тем не менее в последние 30 лет, несмотря на уменьшение распространенности курения, наблюдалась стабилизация и последующий рост заболеваемости ОФПКК. Этот показатель увеличился в основном среди белых мужчин среднего возраста (в том числе среди никогда не куривших или отказавшихся от курения). Эта когорта отличается от обычных больных ОФПКК – лиц пожилого возраста, имеющих большой стаж курения или употребления алкоголя. Такое увеличение заболеваемости ОФПКК в настоящее время связывают с инфицированностью вирусом папилломы человека (ВПЧ). Передача ВПЧ происходит половым путем, а орально-генитальный контакт может привести к ВПЧ-инфицированию ротовой полости и ротоглотки. Существует множество типов ВПЧ, но подавляющее большинство ВПЧ-ассоциированных случаев ОФПКК вызвано вирусом 16-го типа. В этом обзоре обсуждаются эпидемиология ВПЧ-ассоциированной ОФПКК, распространенность инфекции ротовой полости и/или ротоглотки, вызванной ВПЧ, и методы выявления вируса в клетках опухоли.

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