Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press42110.17650/2222-1468-2019-9-3-38-48REVIEWОБЗОРНАЯ СТАТЬЯEfficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case reportЭффективность вандетаниба в лечении медуллярного рака щитовидной железы: обзор литературы и клинический случайhttps://orcid.org/0000-0003-1255-5700MudunovА. М.МудуновА. М.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

Али Мурадович Мудунов

115478 Москва, Каширское шоссе, 24

ali.mudunov@inbox.ruhttps://orcid.org/0000-0002-6851-9867AlymovYu. V.АлымовЮ. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-5421-5985RomanovI. S.РомановИ. С.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-1341-0765PodvyaznikovS. О.ПодвязниковС. О.
Russian Federation

Bld. 1, 2 / 1 Barrikadnaya St., Moscow 125993

125993 Москва, ул. Баррикадная, 2 / 1, стр. 1

https://orcid.org/0000-0002-6796-0968IgnatovaА. V.ИгнатоваА. В. 
Russian Federation

Bld. 1, 2 / 1 Barrikadnaya St., Moscow 125993; 6 Miklukho-Maklaya St., Moscow 117198

125993 Москва, ул. Баррикадная, 2 / 1, стр. 1; 117198 Москва, ул. Миклухо-Маклая, 6

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииRussian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииRUDN UniversityФГАОУ ВО «Российский университет дружбы народов»311020199338483110201931102019Copyright ©; 2019, Mudunov А.М., Alymov Y.V., Romanov I.S., Podvyaznikov S.О., Ignatova А.V.Copyright ©; 2019, Мудунов А.М., Алымов Ю.В., Романов И.С., Подвязников С.О., Игнатова А.В.2019Mudunov А.М., Alymov Y.V., Romanov I.S., Podvyaznikov S.О., Ignatova А.V.Мудунов А.М., Алымов Ю.В., Романов И.С., Подвязников С.О., Игнатова А.В.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/421

Medullary thyroid cancer (MTC) is a rare disorder that accounts for approximately 1.7 % of all thyroid malignancies. MTC is usually detected at early stages; however, approximately 10–15 % of patients are diagnosed with locally advanced MTC and distant metastases. Treatment of such patients is challenging due to biological characteristics of the disease and very few effective treatment approaches available. The investigation of mechanisms of carcinogenesis, as well as advances in pharmacology, allowed the development of a new group of targeted drugs, namely tyrosine kinases, which efficacy against progressive unresectable locally advanced or metastatic MTC has been demonstrated in multiple clinical trials. Vandetanib has been registered for MTC treatment in the Russian Federation. MTC is very rare, thus, each case of vandetanib use for its treatment is particularly interesting. Moreover, since the approval of this drug in 2011 by the U. S. Food and Drug Administration (FDA), new data on the clinical use of vandetanib have been accumulated. Importantly, clinical trials are usually well designed and conducted in near-ideal conditions, whereas the real conditions can be different and patients may have individual characteristics. Therefore, the aim of this study was to update the information on the efficacy and safety of vandetanib by retrospective analysis of available publications and to report a case of MTC treated with vandetanib.

Медуллярный рак щитовидной железы (МРЩЖ) – редкое заболевание, на долю которого приходится 1,7 % всех случаев злокачественных опухолей щитовидной железы. Как правило, МРЩЖ выявляют на ранних стадиях, однако у 10–15 % пациентов опухоль впервые обнаруживают на стадии местно-распространенных форм и отдаленных метастазов. Лечение данной категории пациентов представляет собой сложную задачу из-за биологических особенностей заболевания и небольшого количества эффективных методов. Однако изучение механизмов развития опухоли и развитие современной фармакологии привели к разработке новой группы таргетных препаратов – ингибиторов тирозинкиназ, эффективность которых в лечении нерезектабельного прогрессирующего местно-распространенного или метастатического МРЩЖ продемонстрирована в различных клинических исследованиях. В Российской Федерации для лечения МРЩЖ зарегистрирован и доступен вандетаниб. Ввиду редкости МРЩЖ каждый новый клинический случай применения вандетаниба для его лечения крайне интересен. Более того, с момента одобрения препарата в 2011 г. в США Управление по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA) накопило новые данные о клиническом использовании вандетаниба. Важно, что клинические исследования, как правило, характеризуются хорошо продуманным дизайном и практически идеальными условиями, в то время как в реальной клинической практике условия могут различаться, а пациенты могут обладать индивидуальными особенностями. В связи с этим целью публикации стало обновление информации об эффективности и безопасности вандетаниба, в том числе с учетом ретроспективного анализа научной литературы, имеющейся в медицинских базах, а также описание случая применения вандетаниба в клинической практике.

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