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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">533</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2020-10-2-97-100</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Brain metastases from esophageal cancer: a case-report</article-title><trans-title-group xml:lang="ru"><trans-title>Метастатическое поражение головного мозга при раке пищевода: клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5841-7480</contrib-id><name-alternatives><name xml:lang="en"><surname>Sevian</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Севян</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow 119991</p><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>Надежда Вагаршаковна Севян </p><p>119991 Москва, ул. Большая Пироговская, 2, стр. 4</p><p>115478 Москва, Каширское шоссе, 24</p></bio><email>hope-sev@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bekyashev</surname><given-names>A. Kh.</given-names></name><name xml:lang="ru"><surname>Бекяшев</surname><given-names>А. Х.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8880-1758</contrib-id><name-alternatives><name xml:lang="en"><surname>Prozorenko</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Прозоренко</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>119991 Москва, ул. Большая Пироговская, 2, стр. 4</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozlov</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4218-9652</contrib-id><name-alternatives><name xml:lang="en"><surname>Naskhletashvili</surname><given-names>D. R.</given-names></name><name xml:lang="ru"><surname>Насхлеташвили</surname><given-names>Д. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6325-716X</contrib-id><name-alternatives><name xml:lang="en"><surname>Karakhan</surname><given-names>V. B.</given-names></name><name xml:lang="ru"><surname>Карахан</surname><given-names>В. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gasparyan</surname><given-names>T. G.</given-names></name><name xml:lang="ru"><surname>Гаспарян</surname><given-names>Т. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0147-8554</contrib-id><name-alternatives><name xml:lang="en"><surname>Avtomonov</surname><given-names>D. E.</given-names></name><name xml:lang="ru"><surname>Автомонов</surname><given-names>Д. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>119991 Москва, ул. Большая Пироговская, 2, стр. 4</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5601-3669</contrib-id><name-alternatives><name xml:lang="en"><surname>Bogush</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Богуш</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow 119991</p><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>119991 Москва, ул. Большая Пироговская, 2, стр. 4</p><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0040-3136</contrib-id><name-alternatives><name xml:lang="en"><surname>Kirsanov</surname><given-names>V. Yu.</given-names></name><name xml:lang="ru"><surname>Кирсанов</surname><given-names>В. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>119991 Москва, ул. Большая Пироговская, 2, стр. 4</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6850-6919</contrib-id><name-alternatives><name xml:lang="en"><surname>Vereshchak</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Верещак</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0829-7809</contrib-id><name-alternatives><name xml:lang="en"><surname>Malikhova</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Малихова</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115478</p><p>Bld. 1, 2/1 Barrikadnaya St., Moscow 125993</p></bio><bio xml:lang="ru"><p>115478 Москва, Каширское шоссе, 24</p><p>125993 Москва, ул. Баррикадная, 2/1, стр. 1</p></bio><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-07-24" publication-format="electronic"><day>24</day><month>07</month><year>2020</year></pub-date><volume>10</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>97</fpage><lpage>100</lpage><history><date date-type="received" iso-8601-date="2020-07-24"><day>24</day><month>07</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-07-24"><day>24</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Sevian N.V., Bekyashev A.K., Prozorenko E.V., Kozlov N.A., Naskhletashvili D.R., Karakhan V.B., Gasparyan T.G., Avtomonov D.E., Bogush E.A., Kirsanov V.Y., Vereshchak V.V., Malikhova O.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, Севян Н.В., Бекяшев А.Х., Прозоренко Е.В., Козлов Н.А., Насхлеташвили Д.Р., Карахан В.Б., Гаспарян Т.Г., Автомонов Д.Е., Богуш Е.А., Кирсанов В.Ю., Верещак В.В., Малихова О.А.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Sevian N.V., Bekyashev A.K., Prozorenko E.V., Kozlov N.A., Naskhletashvili D.R., Karakhan V.B., Gasparyan T.G., Avtomonov D.E., Bogush E.A., Kirsanov V.Y., Vereshchak V.V., Malikhova O.A.</copyright-holder><copyright-holder xml:lang="ru">Севян Н.В., Бекяшев А.Х., Прозоренко Е.В., Козлов Н.А., Насхлеташвили Д.Р., Карахан В.Б., Гаспарян Т.Г., Автомонов Д.Е., Богуш Е.А., Кирсанов В.Ю., Верещак В.В., Малихова О.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/533">https://ogsh.abvpress.ru/jour/article/view/533</self-uri><abstract xml:lang="en"><p>Esophageal cancer spreads locally via the circulatory and lymphatic systems and can, extremely rarely, form brain metastases. The development of intracranial metastases is a long-term adverse event indicating poor prognosis. In this paper, we present a case of esophageal cancer<italic> </italic>with a brain metastasis in a patient who received combination therapy and demonstrated long-term progression-free survival.</p></abstract><trans-abstract xml:lang="ru"><p>Рак пищевода распространяется локально через кровеносную и лимфатическую системы и крайне редко метастазирует в головной мозг. Появление интракраниальных метастазов является отсроченным нежелательным явлением и признаком неблагоприятного прогноза. В данной работе представлен клинический случай рака пищевода с метастатическим поражением головного<italic> </italic>мозга, комплексное лечение которого обеспечило хороший контроль над заболеванием и отсутствие рецидивов в течение длительного срока.</p></trans-abstract><kwd-group xml:lang="en"><kwd>esophageal cancer</kwd><kwd>intracranial metastases</kwd><kwd>squamous cell carcinoma</kwd><kwd>metastatic esophageal cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак пищевода</kwd><kwd>интракраниальные метастазы</kwd><kwd>плоскоклеточный рак</kwd><kwd>метастатический рак пищевода</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Аксель Е.М. Статистика злокачественных новообразований желудочно-кишечного тракта. Сибирский онкологический журнал 2017;16(3):5–11. [Axel E.M. Gastrointestinal cancer statistics. 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