Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press60810.17650/2222-1468-2021-11-1-24-33DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИPrinciples of radiotherapy for laryngeal cancerПринципы лучевой терапии рака гортаниhttps://orcid.org/0000-0002-6835-5567AlievaS. B.АлиеваС. Б.
Russian Federation

Sevil Bagaturovna Alieva

24 Kashirskoe Hwy, Moscow 115478

Севил Багатуровна Алиева

115478 Москва, Каширское шоссе, 24

drsevil@mail.ruhttps://orcid.org/0000-0002-4046-1894AzizyanR. I.АзизянР. И.
Russian Federation

24 Kashirskoe Hwy, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-0918-3857MudunovA. M.МудуновА. М.
Russian Federation

1111st Uspenskoe Hwy, Lapino Village, Odintsovsky Dst., Moscow Region 143081

143081 Московская обл., Одинцовский р-н, д. Лапино, 1-е Успенское шоссе, 111

https://orcid.org/0000-0003-0183-4827ZaderenkoI. A.ЗадеренкоИ. А.
Russian Federation

24 Kashirskoe Hwy, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-2674-4553DaykhesN. A.ДайхесН. А.
Russian Federation

Bld. 2, 30 Volokolamskoe Hwy, 123182, Moscow

123182 Москва, Волоколамское шоссе, 30, корп. 2

https://orcid.org/0000-0001-5889-392XDobrokhotovaV. Z.ДоброхотоваВ. З.
Russian Federation

24 Kashirskoe Hwy, Moscow 115478; Bld. 4, 2 Bolshaya Pirogovskaya St., Moscow 119991

115478 Москва, Каширское шоссе, 24; 119991 Москва, ул. Большая Пироговская, 2, стр. 4

https://orcid.org/0000-0002-5081-8973NovozhilovaE. N.НовожиловаЕ. Н.
Russian Federation

27, Istra Village, Stepanovskoe, Krasnogorskiy Dst., Moscow Region 143423

143423 Московская область, Красногорский р-н, п/о Степановское, пос. Истра, 27

https://orcid.org/0000-0001-8600-1343ReshulskiyS. S.РешульскийС. С.
Russian Federation

Bld. 2, 30 Volokolamskoe Hwy, 123182, Moscow

123182 Москва, Волоколамское шоссе, 30, корп. 2

https://orcid.org/0000-0002-5570-684XBorisovaT. N.БорисоваТ. Н.
Russian Federation

24 Kashirskoe Hwy, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-7808-5396VinogradovV. V.ВиноградовВ. В.
Russian Federation

Bld. 2, 30 Volokolamskoe Hwy, 123182, Moscow

123182 Москва, Волоколамское шоссе, 30, корп. 2

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ Национальный медицинский исследовательский центр онкологии им. Н.Н. БлохинаLapino Clinical HospitalКлинический госпиталь ЛапиноNational Medical Research Center for Otorhinolaryngology, Federal Medico-Biological Agency of RussiaФГБУ Национальный медицинский исследовательский центр оториноларингологии Федерального медико-биологического агентстваI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииMoscow Cancer Hospital No. 62, Moscow Healthcare DepartmentГБУЗ Московская городская онкологическая больница № 62 Департамента здравоохранения г. Москвы2404202111124332304202123042021Copyright ©; 2021, Alieva S.B., Azizyan R.I., Mudunov A.M., Zaderenko I.A., Daykhes N.A., Dobrokhotova V.Z., Novozhilova E.N., Reshulskiy S.S., Borisova T.N., Vinogradov V.V.Copyright ©; 2021, Алиева С.Б., Азизян Р.И., Мудунов А.М., Задеренко И.А., Дайхес Н.А., Доброхотова В.З., Новожилова Е.Н., Решульский С.С., Борисова Т.Н., Виноградов В.В.2021Alieva S.B., Azizyan R.I., Mudunov A.M., Zaderenko I.A., Daykhes N.A., Dobrokhotova V.Z., Novozhilova E.N., Reshulskiy S.S., Borisova T.N., Vinogradov V.V.Алиева С.Б., Азизян Р.И., Мудунов А.М., Задеренко И.А., Дайхес Н.А., Доброхотова В.З., Новожилова Е.Н., Решульский С.С., Борисова Т.Н., Виноградов В.В.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/608

Radiation therapy as one of the main specific method of treatment is widely used to treat patients with laryngeal cancer. Currently, the main radiotherapy technique for the treatment of patients with head and neck cancer is linear electron accelerators that can provide individual, complex configurations of radiation volumes. The article presents new modern technologies of radiation therapy in the early and locally-advanced stages of the disease, principles of organ-preservation treatment in laryngeal tumors, indications for pre-and postoperative radiation, methods of prevention of post-therapeutic complications.

Лучевая терапия широко применяется как один из основных методов специфического лечения рака гортани. В настоящее время радиотерапевтическая техника для лечения больных раком головы и шеи представлена в основном линейными ускорителями электронов, способными создать индивидуальные, сложные конфигурации объемов облучения. В статье описаны новые технологии лучевой терапии заболевания на ранних и местно-распространенных стадиях, принципы органосохраняющего лечения при опухолях гортани, показания к пред- и послеоперационному облучению, методы профилактики посттерапевтических осложнений.

laryngeal cancerradiation therapyorgan-preservation therapyрак гортанилучевая терапияорганосохраняющее лечениеMendenhall W.M., Werning J.W., Hinerman R.W. et al. Management of T1-T2 glottic carcinomas. Cancer 2004;100:1786-92. DOI: 10.1002/cncr.20181.Chera B.S., Amdur R.J., Morris C.G. et al. T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 2010;78:461-6. DOI: 10.1016/j.ijrobp.2009.08.066.Paches A.I. Head and neck tumors. Moscow: Meditsina, 2001. (In Russ.).Пачес А.И. Опухоли головы и шеи. М.: Медицина, 2001.Lederman M. The place of radiotherapy in the treatment of cancer of the larynx. Ann Radiol (Paris) 1961;4:433-54. DOI: 10.1136/bmj.1.5240.1639.The International Commission on Radiation Units and Measurements. J ICRU 2010;10(2):5—6. DOI: 10.1093/jicru/ndq025.Yamazaki H., Suzuki G., Nakamura S. et al. Radiotherapy for laryngeal cancer — technical aspects and alternate fractionation. J Radiat Res 2017;58(4):495—508. DOI: 10.1093/jrr/rrx023.Chera B.S., Amdur R.J., Morris C.G. et al. T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 2010;78(2):461-6. DOI: 10.1016/j.ijrobp.2009.08.066.Tamura Y., Tanaka S., Asato R. et al. Therapeutic outcomes of laryngeal cancer at Kyoto University Hospital for 10 years. Acta Otolaryngol Suppl 2007;(557):62—5. DOI: 10.1080/00016480601067990.Blanch J.L., Vilaseca I., Caballero M. et al. Outcome of transoral laser microsurgery for T2-T3 tumors growing in the laryngeal anterior commissure. Head Neck 2011;33(9):1252-9. DOI: 10.1002/hed.21605.Aaltonen L.M., Rautiainen N., Sellman J. et al. Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy. Int J Radiat Oncol Biol Phys 2014;90(2):255-60. DOI: 10.1016/j.ijrobp.2014.06.032.Higgins K.M., Shah M.D., Ogaick M.J., Enepekides D. Treatment of early-stage glottic cancer: meta-analysis comparison of laser excision versus radiotherapy. J Otolaryngol Head Neck Surg 2009;38(6):603. DOI: 10.2310/7070.2009.080235.Amdur R.J., Parsons J.T., Mendenhall W.M. et al. Postoperative irradiation for squamous cell carcinoma of the head and neck: an analysis of treatment results and complications. Int J Radiat Oncol Biol Phys 1989;16:25-36. DOI: 10.1016/0360-3016(89)90006-0.Wolf G.Y., Fisher S.G., Hong W.K. et al. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991;324(24):1685-90. DOI: 10.1016/0196-0709(91)90133-z.Forastiere A.A., Goepfert H., Maor M. et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349(22):2091-8.Mendenhall W.M., Amdur R.J., Morris C.G. et al. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 2001;19:4029-36. DOI: 10.1200/jco.2001.19.20.4029.Yamazaki H., Nishiyama K., Tanaka E. et al. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys 2006;64:77-82.Megan E.D., Le Q.T., Jain A.K. et al. Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx. Head Neck 2011;33:103-11. DOI: 10.1016/j.ijrobp.2005.06.014.Practical Radiation Oncology. Ed. by S. Mallick, G.K. Rath, R. Benson. Singapore: Springer, 2020. 300 p. DOI: 10.1007/978-981-15-0073-2.Mendenhall W.M., Riggs C.E., Cassisi N.J. Treatment of head and neck cancers. In: DeVita, Hellman, and Rosenberg’s Cancer: principles and practice of oncology. Ed. by V.T. DeVita, S. Hellman, S.A. Rosenberg. Philadelphia: Lippincott Williams & Wilkins, 2008. Pp. 809-814. DOI: 10.1007/3-540-35665-7_18.Gourin C.G., Conger B.T., Sheils W.C. et al. The effect of treatment on survival in patients with advanced laryngeal carcinoma. Laryngoscope 2009;119:1312-7. DOI: 10.1002/lary.20477.Hinerman R.W., Mendenhall W.M., Amdur R.J. et al. Carcinoma of the supraglottic larynx: treatment results with radiotherapy alone or with planned neck dissection. Head Neck 2002;24:456-67. DOI: 10.1002/hed.10069.Bernier J., Cooper J.S., Pajak T.F. et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501). Head Neck 2005;27(10):843-50. DOI: 10.1002/hed.20279.Cooper J.S., Zhang O., Pajak T.F. et al. Long-term follow-up of the RTOG 9501/ intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2012;84(5):1198—205. DOI: 10.1016/j.ijrobp.2012.05.008.Amdur R.J., Parsons J.T., Mendenhall WM. et al. Postoperative irradiation for squamous cell carcinoma of the head and neck: an analysis of treatment results and complications. Int J Radiat Oncol Biol Phys 1989;16:25-36. DOI: 10.1016/0360-3016(89)90006-0.Forastiere A.A., Zhang Q., Weber R.S. et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 2013;31(7):845-52. DOI: 10.1200/jco.2012.43.6097.Hoffman H.T., Porter K., Karnell L.H. et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 2006;116:1-13. DOI: 10.1097/01.mlg.0000236095.97947.26.Dziegielewski P.T., O’Connell D.A., Klein M. et al. Primary total laryngectomy versus organ preservation for T3/T4a laryngeal cancer: a population-based analysis of survival. J Otolaryngol Head Neck Surg 2012;41 Suppl 1:S56-64. DOI: 10.2310/7070.2011.110081.Megwalu U.C., Sikora A.G. Survival outcomes in advanced laryngeal cancer. JAMA Otolaryngol Head Neck Surg 2014;140:855-60. DOI: 10.1001/jamaoto.2014.1671.Tkachev S.I., Matyakin Ye.G., Lubayev V.L. et al. Comparative evaluation of 5-year results of surgical, combined, radiation and chemoradiotherapy in laryngeal cancer (T3N0M0). Voprosy onkologii = Problems of Oncology 2006;52(4):404-8. (In Russ.).Ткачев С.И., Матякин Е.Г., Любаев В.Л. и др. Сравнительная оценка пятилетних результатов хирургического, комбинированного, лучевого и химиолучевого методов лечения рака гортани в стадии T3N0M0. Вопросы онкологии 2006;52(4):404-8.Mendenhall W.M., Morris C.G.,Amdur R.J. et al. Parameters that predict local control after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck 2003;25:535-42. DOI: 10.1002/hed.10253.Association of Oncologists of Russia and the Russian Society of Specialists in Head and Neck Tumors Clinical guidelines for the treatment of laryngeal tumors. Available at: https://oncology-association.ru/files/clinical-guidelines-2020/Rak_gortani.pdf. (In Russ.).Клинические рекомендации по лечению опухолей гортани под редакцией Ассоциации онкологов России и Российского общества специалистов по опухолям головы и шеи. Доступно по: https://oncology-association.ru/files/clinical-guidelines-2020/Rak_gortani.pdf.Specenier P., Vermorken J.B Cetuximab: its unique place in head and neck cancer treatment. Biologics 2013;7:77-90. DOI: 10.2147/btt.s43628.Al-Othman M.O., Amdur R.J., Morris C.G. et al. Does feeding tube placement predict for long-term swallowing disability after radiotherapy for head and neck cancer? Head Neck 2003;25:741-7. DOI: 10.1002/hed.10279.