Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press72210.17650/2222-1468-2021-11-4-97-109REVIEWОБЗОРНАЯ СТАТЬЯDermatologic adverse events associated with epidermal growth factor receptor inhibitors: current concepts of interdisciplinary problemДерматологические нежелательные явления ингибиторов рецептора эпидермального фактора роста: современный взгляд на междисциплинарную проблемуhttps://orcid.org/0000-0001-6888-4760PolonskaiaA. S.ПолонскаяА. С.
Russian Federation

Bld. 1a, 19 Marshala Timoshenko St., Moscow 121359Bld. 10, 27 Lomonosovsky Prospekt, Moscow 119192

Александра Сергеевна Полонская

121359 Москва, ул. Маршала Тимошенко, 19, стр. 1а119192 Москва, Ломоносовский пр-т, 27, корп. 10

dr.polonskaia@gmail.comhttps://orcid.org/0000-0002-0238-6563ShatokhinaE. A.ШатохинаЕ. А.
Russian Federation

Bld. 1a, 19 Marshala Timoshenko St., Moscow 121359Bld. 10, 27 Lomonosovsky Prospekt, Moscow 119192

121359 Москва, ул. Маршала Тимошенко, 19, стр. 1а119192 Москва, Ломоносовский пр-т, 27, корп. 10

https://orcid.org/0000-0002-5044-5265KruglovaL. S.КругловаЛ. С.
Russian Federation

Bld. 1a, 19 Marshala Timoshenko St., Moscow 121359

121359 Москва, ул. Маршала Тимошенко, 19, стр. 1а

Central State Medical Academy of the Presidential Administration of the Russian FederationФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииMedical Scientific and Educational Center of M. V. Lomonosov Moscow State UniversityФГБУ «Медицинский научно-образовательный центр Московского государственного университета им. М. В. Ломоносова»14122021114971091402202214022022Copyright ©; 2021, Polonskaia A.S., Shatokhina E.A., Kruglova L.S.Copyright ©; 2021, Полонская А.С., Шатохина Е.А., Круглова Л.С.2021Polonskaia A.S., Shatokhina E.A., Kruglova L.S.Полонская А.С., Шатохина Е.А., Круглова Л.С.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/722

Epidermal growth factor receptor inhibitors (EGFR) have a high rate of class-specific dermatologic adverse events. Supportive treatment of dermatologic adverse events decreases their severity, minimizes the need for dose de-escalation / discontinuation of targeted therapy, improves commitment to anticancer treatment and patient’s quality of life. Close interdisciplinary cooperation between oncologists and dermatologists is a key to the successful management of patients treated with EGFR. This article highlights current approaches to classification, concepts of pathogenesis and clinical course of EGFR-associated dermatologic adverse events, current and promising prophylactic and therapeutic strategies to manage these adverse events.

При использовании ингибиторов рецептора эпидермального фактора роста (epidermal growth factor receptor, EGFR) часто развиваются класс-специфические побочные эффекты в виде дерматологических нежелательных явлений. Сопроводительное лечение снижает тяжесть этих явлений и минимизирует необходимость деэскалации дозы / отмены противоопухолевого препарата, повышает приверженность пациентов проводимой противоопухолевой терапии и их качество жизни. Тесное междисциплинарное сотрудничество врачей-онкологов и дерматовенерологов является ключом к успешному ведению больных, получающих ингибиторы EGFR. В данной статье освещаются современные представления о классификации, патогенезе и клинической картине дерматологических нежелательных явлений при использовании ингибиторов EGFR, а также рассказывается об актуальных и перспективных методах профилактического и сопроводительного лечения данных явлений.

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