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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">812</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2022-12-3-28-36</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Features of the clinical course and prognosis of tongue cancer in young women</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности клинического течения и прогноз рака языка у женщин молодого возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9132-3416</contrib-id><name-alternatives><name xml:lang="en"><surname>Kropotov</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Кропотов</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7356-8321</contrib-id><name-alternatives><name xml:lang="en"><surname>Yakovleva</surname><given-names>L. P.</given-names></name><name xml:lang="ru"><surname>Яковлева</surname><given-names>Л. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>86 Shosse Entuziastov, Moscow 111123</p></bio><bio xml:lang="ru"><p>111123 Москва, шоссе Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2793-5597</contrib-id><name-alternatives><name xml:lang="en"><surname>Safarov</surname><given-names>D.  A.</given-names></name><name xml:lang="ru"><surname>Сафаров</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>David Afatdinovich Safarov</p><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>Давид Афатдинович Сафаров </p><p>115522 Москва, Каширское шоссе, 24</p></bio><email>SafarowD@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2283-1812</contrib-id><name-alternatives><name xml:lang="en"><surname>Saprina</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Саприна</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Peshko</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Пешко</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5706-912X</contrib-id><name-alternatives><name xml:lang="en"><surname>Khodos</surname><given-names>A.  V.</given-names></name><name xml:lang="ru"><surname>Ходос</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>86 Shosse Entuziastov, Moscow 111123</p></bio><bio xml:lang="ru"><p>111123 Москва, шоссе Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">A.S. Loginov Moscow Clinical Scientific Center of the Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Московский клинический научный центр им. А. С. Логинова Департамента здравоохранения г. Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-10-14" publication-format="electronic"><day>14</day><month>10</month><year>2022</year></pub-date><volume>12</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>28</fpage><lpage>36</lpage><history><date date-type="received" iso-8601-date="2022-12-13"><day>13</day><month>12</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-12-13"><day>13</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Kropotov M.A., Yakovleva L.P., Safarov D.A., Saprina O.A., Peshko D.A., Khodos A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Кропотов М.А., Яковлева Л.П., Сафаров Д.А., Саприна О.А., Пешко Д.А., Ходос А.В.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Kropotov M.A., Yakovleva L.P., Safarov D.A., Saprina O.A., Peshko D.A., Khodos A.V.</copyright-holder><copyright-holder xml:lang="ru">Кропотов М.А., Яковлева Л.П., Сафаров Д.А., Саприна О.А., Пешко Д.А., Ходос А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/812">https://ogsh.abvpress.ru/jour/article/view/812</self-uri><abstract xml:lang="en"><p><bold>Introduction.</bold> In recent times, changes in epidemiology of tongue cancer have been observed. morbidity among nonsmoking and non-abusing alcohol young women have been rising. Currently, etiology and pathogenesis of tumor development in this nosological group are unclear and require detailed analysis of epidemiologic and clinical data.</p><p><bold>Aim.</bold> To analyze the clinical material on the incidence of tongue cancer among young women (under 45 years old) over a 10-year period and assess the prevalence of this pathology in this group, the methods of treatment and reconstruction used, and determine the prognosis.</p><p><bold>Materials and methods.</bold> The study included 68 female patients with squamous cell carcinoma of the tongue who received treatment between 2010 and 2020. mean age was 36.8 years (between 18 and 45 years; median – 39 years). None of the patients had history of alcohol abuse or smoking. In 32 (47.1 %) patients, primary diagnosis was made at stages I–II, in 36 (52.9 %) at stages III–Iv.</p><p><bold>Results.</bold> In the last 10 years, a trend towards increased morbidity of tongue cancer among young women have been observed. In 2010, 2 cases of the disease were detected, in 2019–13, in 2020–14. mean follow-up duration was 40 months (median 32 months). Overall 5-year survival in this period was 72.5 ± 6.5 %, recurrence-free 5-years survival was 66.5 ± 6.6 %. <bold>Conclusion.</bold> Increase on tongue cancer morbidity among young non-smoking women is a new epidemiological trend worldwide. Etiological and pathogenetic factors of this trend have not been studied and require large multicenter studies for obtaining statistically significant results. Early medical resource utilization in this social group allows to perform adequate surgical intervention but requires the head and neck tumor specialist to pay attention to reconstructive surgery, quality and early patient rehabilitation allowing to preserve high quality of life, capacity for work and social activity.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение.</bold> В последнее время отмечаются изменения в эпидемиологии рака языка. Возрастает заболеваемость среди некурящих и не злоупотребляющих алкоголем женщин молодого возраста. На сегодняшний день этиология и патогенез развития опухоли в данной нозологической группе неясны, что требует детального анализа эпидемиологических и клинических данных.</p><p><bold>Цель исследования </bold>– проанализировать клинический материал по заболеваемости раком языка среди молодых женщин (до 45 лет) за 10-летний период и оценить распространенность данной патологии в названной группе, применяемые методы лечения и реконструкции и определить прогноз.</p><p><bold>Материалы и методы.</bold> В исследование вошли 68 пациенток с плоскоклеточным раком языка, прошедших лечение с 2010 по 2020 г. средний возраст больных составил 36,8 года (от 18 до 45 лет; медиана 39 лет). Ни одна включенная в исследование пациентка не имела в анамнезе фактов злоупотребления алкоголем и табакокурения. у 32 (47,1 %) больных первичный диагноз был установлен на I–II стадии заболевания, у 36 (52,9 %) – на III–Iv.</p><p><bold>Результаты.</bold> В последние 10 лет наблюдается тенденция к увеличению частоты заболеваемости раком языка среди женщин молодого возраста. В 2010 г. выявлено 2 случая заболевания, в 2019 г. – 13, в 2020 г. – 14. среднее время наблюдения за пациентками – 40 мес (медиана 32 мес). показатели общей 5-летней выживаемости за данный период наблюдения составили 72,5 ± 6,5 %, безрецидивной 5-летней выживаемости – 66,5 ± 6,6 %.</p><p><bold>Заключение. </bold>Рост заболеваемости плоскоклеточным раком языка среди некурящих женщин молодого возраста становится новым эпидемиологическим трендом во всем мире. Этиологические и патогенетические факторы данного явления не изучены, что требует проведения крупных многоцентровых исследований для получения статистически значимых результатов. Раннее обращение за медицинской помощью в данной социальной группе позволяет проводить адекватное хирургическое вмешательство, однако обязывает специалиста по опухолям головы и шеи уделять все большее внимание вопросам реконструктивной хирургии, качественной и ранней реабилитации пациентов, позволяющей сохранить высокий уровень их жизни, работоспособность и социальную активность. </p></trans-abstract><kwd-group xml:lang="en"><kwd>cancer of the oral mucosa</kwd><kwd>tongue cancer</kwd><kwd>young women</kwd><kwd>head and neck tumors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак слизистой оболочки полости рта</kwd><kwd>рак языка</kwd><kwd>женщины молодого возраста</kwd><kwd>опухоли головы и шеи</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1.	Amit M., Yen T.C., Liao C.T. et al. 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