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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">849</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2022-12-4-102-108</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Metastatic basal cell skin cancer with distant metastatic skeletal lesions: a clinical case report</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническое наблюдение метастатического базальноклеточного рака кожи с поражением костей скелета</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2095-5931</contrib-id><name-alternatives><name xml:lang="en"><surname>Polyakov</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Поляков</surname><given-names>А. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 2nd Botkinskij proezd, Moscow 125284</p></bio><bio xml:lang="ru"><p>125284 Москва, 2‑й Боткинский проезд, 3</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2976-8895</contrib-id><name-alternatives><name xml:lang="en"><surname>Buharov</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Бухаров</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 2nd Botkinskij proezd, Moscow 125284</p></bio><bio xml:lang="ru"><p>125284 Москва, 2‑й Боткинский проезд, 3</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9157-5330</contrib-id><name-alternatives><name xml:lang="en"><surname>Miroshnichenko</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Мирошниченко</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Daria Andreevna Miroshnichenko</p><p>3 2nd Botkinskij proezd, Moscow 125284</p></bio><bio xml:lang="ru"><p>Дарья Андреевна Мирошниченко</p><p>125284 Москва, 2‑й Боткинский проезд, 3</p></bio><email>dariamiroshnichenko1996@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">P. A. Herzen Moscow Research Oncological Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-10" publication-format="electronic"><day>10</day><month>12</month><year>2022</year></pub-date><volume>12</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>102</fpage><lpage>108</lpage><history><date date-type="received" iso-8601-date="2023-03-10"><day>10</day><month>03</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-03-10"><day>10</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Polyakov A.P., Buharov A.V., Miroshnichenko D.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Поляков А.П., Бухаров А.В., Мирошниченко Д.А.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Polyakov A.P., Buharov A.V., Miroshnichenko D.A.</copyright-holder><copyright-holder xml:lang="ru">Поляков А.П., Бухаров А.В., Мирошниченко Д.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/849">https://ogsh.abvpress.ru/jour/article/view/849</self-uri><abstract xml:lang="en"><p>Clinical cases of distant metastasis of basal cell skin cancer are extremely rarely described in the international publications. This is probably due to the specific locally advanced growth of this histological type of tumor, as well as to the improvement of radical treatment methods for this group of patients. However, despite the development of both diagnostic research methods and treatment tactics, a large number of patients, especially when the primary tumor is located on the face and neck region, choose less effective and not always radical methods of treatment. In turn, non-radical removal of the primary tumor leads not only to difficulties in local control of the disease, but also to lymphogenous, as well as hematogenous spread of tumor cells and the manifestation of systemic metastasis.</p><p>In the article, we present a clinical case of metastatic basal cell skin carcinoma of the periorbital region with lesions of the bones of the skeleton, namely the thoracic vertebrae manifested 11 years after the detection of the primary tumor.</p></abstract><trans-abstract xml:lang="ru"><p>В мировой литературе крайне редко описываются случаи отдаленного метастазирования базальноклеточного рака кожи. Вероятно, это связано с местно-распространенным характером роста данного гистологического типа опухоли, а также с усовершенствованием методов радикального лечения. Однако, несмотря на развитие диагностических методов и тактик терапии, при лечении большого числа пациентов, особенно при расположении первичного опухолевого очага на коже головы и шеи, специалисты выбирают менее эффективные и не всегда радикальные методы. В свою очередь, нерадикальное удаление первичного опухолевого очага не только затрудняет локальный контроль над заболеванием, но и приводит к лимфогенному и гематогенному распространению опухолевых клеток, а также к появлению системных метастатических очагов.</p><p>В статье описан клинический случай метастатического поражения костей скелета, а именно грудных позвонков, при базальноклеточном раке кожи периорбитальной области через 11 лет после выявления первичного опухолевого очага.</p></trans-abstract><kwd-group xml:lang="en"><kwd>basal cell skin carcinoma</kwd><kwd>metastatic basal cell skin carcinoma</kwd><kwd>distant metastasis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак кожи</kwd><kwd>метастатический базальноклеточный рак кожи</kwd><kwd>отдаленные метастазы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Monroe M., Kakarala K. Management of advanced basal cell carcinoma of the head and neck. 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