Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press85010.17650/2222-1468-2022-12-4-109-115CLINICAL CASEКЛИНИЧЕСКИЙ СЛУЧАЙCurrent trends in the treatment of recurrent adenocystic cancer of the salivary glands: case reportСовременные тенденции в лечении рецидивирующего аденокистозного рака слюнных желез: клинический случайhttps://orcid.org/0000-0002-2283-1812SaprinaO. A.СапринаО. А.
Russian Federation

Oksana Alexandrovna Saprina

24 Kashirskoe Shosse, Moscow 115522

Оксана Александровна Саприна

115522 Москва, Каширское шоссе, 24

isabekian@mail.ruhttps://orcid.org/0000-0002-9132-3416KropotovM. A.КропотовМ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-9807-2229TulyandinS. A.ТюляндинС. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-4944-2507GaninaK. A.ГанинаК. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-3852-3969KozlovN. A.КозловН. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

ViziginaB. B.ВыжигинаБ. Б.
Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России101220221241091151003202310032023Copyright ©; 2022, Saprina O.A., Kropotov M.A., Tulyandin S.A., Ganina K.A., Kozlov N.A., Vizigina B.B.Copyright ©; 2022, Саприна О.А., Кропотов М.А., Тюляндин С.А., Ганина К.А., Козлов Н.А., Выжигина Б.Б.2022Saprina O.A., Kropotov M.A., Tulyandin S.A., Ganina K.A., Kozlov N.A., Vizigina B.B.Саприна О.А., Кропотов М.А., Тюляндин С.А., Ганина К.А., Козлов Н.А., Выжигина Б.Б.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/850

Salivary gland carcinomas is a rare family of neoplasms with different histological characteristics and biological behavior. Treatment regimens have remained virtually unchanged for decades, leaving the leading role for surgical treatment and radiation therapy. However, a special place in the salivary gland carcinomas group is occupied by adenoid cystic carcinoma, which is quite often characterized by a recurrent and / or metastatic course with the use of chemotherapy as the main option in treatment. It is worth noting the fact that the results of standard chemotherapy regimens show unsatisfactory results, respectively, with recurrent or metastatic adenoid cystic carcinoma, treatment options are minimal. Accordingly, there is a need to study new therapeutic methods for the treatment of this disease. In this situation, high hopes were placed on targeted therapy, in particular, the family of epidermal growth factor receptors, c-Kit are the most frequently studied molecular targets. Due to the rare occurrence of adenoid cystic carcinoma, the number of cases of using targeted therapy for analysis is relatively small, so each clinical observation is of particular value. The following is a clinical case of treatment of recurrent adenoid cystic carcinoma using a personalized treatment approach.

Aim. To describe the clinical observation of the use of targeted drugs in recurrent or metastatic adenocystic cancer of the salivary glands.

Рак слюнных желез представляет собой редкое злокачественное новообразование с различными гистологическими характеристиками и биологическим поведением. Режимы лечения данной патологии практически не менялись на протяжении десятилетий: в основном применяются хирургическое вмешательство и лучевая терапия. Особое место в опухолях этой локализации занимает аденокистозный рак, который в основном характеризуется рецидивирующим и / или метастатическим течением. Главной опцией в его лечении является химиотерапия. Стоит отметить, что применение стандартных схем химиотерапии показывает неудовлетворительные результаты: при рецидивирующем или метастатическом аденокистозном раке слюнных желез варианты лечения минимальны. В связи с этим существует необходимость изучения новых методов терапии данного заболевания. В такой ситуации большие надежды возлагают на таргетную терапию, в частности на применение семейства рецепторов эпидермального фактора роста и c-Kit, которые являются наиболее исследуемыми молекулярными мишенями. Из-за редкой встречаемости аденокистозного рака число случаев использования данного лечения относительно невелико, поэтому каждое клиническое наблюдение представляет особую ценность. В статье представлен клинический случай терапии рецидивирующего аденокистозного рака слюнных желез с применением персонализированного подхода.

Цель работы – описание клинического наблюдения применения таргетных препаратов при рецидивирующем или метастатическом аденокистозном раке слюнных желез.

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