Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press8610.17650/2222-1468-2012-0-3-59-62ORIGINAL REPORTSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯCAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCERКАПЕЦИТАБИН В ЛЕЧЕНИИ МЕТАСТАТИЧЕСКОГО ПОРАЖЕНИЯ ГОЛОВНОГО МОЗГА У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫMoskvinaE. A.МосквинаЕ. А.
Russian Federation
k.moskvina@mail.ruGorbunovaV. A.ГорбуноваВ. А.
Russian Federation
NaskhletashviliD. R.НасхлеташвилиД. Р.
Russian Federation
BekyashevA. Kh.БекяшевА. Х.
Russian Federation
MedvedevS. V.МедведевС. В.
Russian Federation
PetersonS. B.ПетерсонС. Б.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава России, МоскваN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва150420122359621804201518042015Copyright ©; 2012, Moskvina E.A., Gorbunova V.A., Naskhletashvili D.R., Bekyashev A.K., Medvedev S.V., Peterson S.B.Copyright ©; 2012, Москвина Е.А., Горбунова В.А., Насхлеташвили Д.Р., Бекяшев А.Х., Медведев С.В., Петерсон С.Б.2012Moskvina E.A., Gorbunova V.A., Naskhletashvili D.R., Bekyashev A.K., Medvedev S.V., Peterson S.B.Москвина Е.А., Горбунова В.А., Насхлеташвили Д.Р., Бекяшев А.Х., Медведев С.В., Петерсон С.Б.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/86

The paper considers the experience with capecitabine in 67 patients with brain metastatic lesion from breast cancer. The immediate efficacy of capecitabine and the results of therapy with the agent were analyzed in the groups of its use alone and in combination with radiotherapy both for therapeutic purposes and as an adjuvant regimen. In the chemoradiation therapy group, the objective effects in the brain were 73 %. The median time to progression was 12.27 months. In the monochemotherapy group, the objective effects were 30 %. The median time to progression was 4 months. The results of the investigation show that capecitabine has pronounced antitumor activity and moderate toxicity. Combination treatment is the method of choice. 

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