<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">871</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2023-13-1-91-101</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Follow-up after radioiodine remnant ablation in differentiated thyroid cancer: the view of nuclear medicine physician</article-title><trans-title-group xml:lang="ru"><trans-title>Динамический контроль после радиойодабляции при дифференцированном раке щитовидной железы: взгляд радиолога</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4934-2012</contrib-id><name-alternatives><name xml:lang="en"><surname>Shurinov</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Шуринов</surname><given-names>А. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Andrey Yur’evich Shurinov</p><p>4 Koroleva St., Obninsk 249036</p></bio><bio xml:lang="ru"><p>Андрей Юрьевич Шуринов</p><p>249036 Обнинск, ул. Королева, 4</p></bio><email>shurinov@mrrc.obninsk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3306-5906</contrib-id><name-alternatives><name xml:lang="en"><surname>Borodavina</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Бородавина</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>4 Koroleva St., Obninsk 249036</p></bio><bio xml:lang="ru"><p> 249036 Обнинск, ул. Королева, 4</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Center of Radiology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Медицинский радиологический научный центр им. А.Ф. Цыба – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-06-02" publication-format="electronic"><day>02</day><month>06</month><year>2023</year></pub-date><volume>13</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>91</fpage><lpage>101</lpage><history><date date-type="received" iso-8601-date="2023-06-01"><day>01</day><month>06</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-06-01"><day>01</day><month>06</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Shurinov A.Y., Borodavina E.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Шуринов А.Ю., Бородавина Е.В.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Shurinov A.Y., Borodavina E.V.</copyright-holder><copyright-holder xml:lang="ru">Шуринов А.Ю., Бородавина Е.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/871">https://ogsh.abvpress.ru/jour/article/view/871</self-uri><abstract xml:lang="en"><p>Timeliness of accurate dynamic observation and a clear understanding of the treatment response guarantees health of patients with differentiated thyroid cancer. Multidimensional approach to evaluation of thyroid-stimulating hormone, tumor markers, ultrasound picture, as well as results of molecular imaging with radioactive iodine is clearly defined in international clinical guidelines. At the A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center for more than 15 years tactics of control exam 6 months after radioactive iodine ablation has been implemented. The aim of the current article is to consider the sequence of diagnostic search for different responses to treatment of differentiated thyroid cancer.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность корректного динамического наблюдения и четкое понимание ответа на лечение при дифференцированном раке щитовидной железы является залогом здоровья пациентов. Комплексный подход к оценке показателей уровня тиреотропного гормона, онкомаркеров, ультразвуковой картины, а также результатов молекулярной визуализации с радиоактивным йодом четко определены в международных клинических руководствах. В Медицинском радиологическом научном центре им. А. Ф. Цыба – филиале ФГБУ «Национальный медицинский исследовательский центр радиологии» более 15 лет применяется тактика контрольного обследования пациентов через 6 мес после проведенной радиойодабляции. Целью данной статьи является рассмотрение последовательности диагностического поиска при различных вариантах ответа на лечение дифференцированного рака щитовидной железы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>radioactive iodine ablation</kwd><kwd>dynamic observation</kwd><kwd>differentiated thyroid cancer</kwd><kwd><sup>131</sup>I whole-body scintigraphy</kwd><kwd><sup>131</sup>I single-photon emission computed tomography/X-ray computed tomography</kwd><kwd><sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography</kwd><kwd>TENIS syndrome</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>радиойодабляция</kwd><kwd>динамическое наблюдение</kwd><kwd>дифференцированный рак щитовидной железы</kwd><kwd>сцинтиграфия всего тела с <sup>131</sup>I</kwd><kwd>однофотонная эмиссионная компьютерная томография, совмещенная с рентгеновской компьютерной томографией, с <sup>131</sup>I</kwd><kwd>позитронная эмиссионная томография, совмещенная с компьютерной томографией, с <sup>18</sup>F-фтордезоксиглюкозой</kwd><kwd>TENIS-синдром</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Filetti S., Durante C., Hartl D., Leboulleux S. et al. Berruti on behalf of the ESMO Guidelines Committee. 2019. Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019;30(12):1856–83. DOI: 10.1093/ annonc/mdz400</mixed-citation><mixed-citation xml:lang="ru">Filetti S., Durante C., Hartl D., Leboulleux S. et al. Berruti on behalf of the ESMO Guidelines Committee. 2019. Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019;30(12):1856–83. DOI: 10.1093/annonc/mdz400</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Клинические рекомендации. Дифференцированный рак щитовидной железы. 2020 г. Доступно по: https://cr.minzdrav.gov. ru/schema/329_1#doc_a1. Clinical recommendations. Differentiated thyroid cancer. 2020 y. Available by: https://cr.minzdrav.gov.ru/schema/329_1#doc_a1. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Клинические рекомендации. Дифференцированный рак щитовидной железы. 2020 г. Доступно по: https://cr.minzdrav.gov.ru/schema/329_1#doc_a1.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>Gulec S., Ahuja S., Avram A. et al. A joint statement from the American Thyroid Association, the European Association of Nuclear Medicine, the European Thyroid Association, the Society of Nuclear Medicine and Molecular Imaging on Current Diagnostic and Theranostic Approaches in the Management of Thyroid Cancer. Thyroid 2021;31(7):1009–19. DOI: 10.1089/ thy.2020.0826</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Haddad R., Bischoff L., Ball D. et al. Thyroid Carcinoma. Version 2.2022. NCCN Clinical Practice Guidelines in Oncology. J Nat Compr Canc Netw 2022;20(8):925–51. DOI: 10.6004/ jnccn.2022.0040</mixed-citation></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Шуринов А.Ю., Крылов В.В., Бородавина Е.В. Радиойодаблация при раке щитовидной железы. Исторические и современные аспекты. Обзор литературы. Онкологический журнал: лучевая диагностика, лучевая терапия 2021;4(4):9–19. DOI: 10.37174/2587-7593-2021-4-4-9-19 Shurinov A.Yu., Krylov V.V., Borodavina E.V. Radioiodablation in thyroid cancer. Historical and modern aspects. Literature review. Onkologicheskij zhurnal: luchevaya diagnostika, luchevaya terapiya = Oncological Journal: radiation diagnostics, radiation therapy 2021;4(4):9–19. (In Russ.). DOI: 10.37174/2587-7593- 2021-4-4-9-19</mixed-citation><mixed-citation xml:lang="ru">Шуринов А.Ю., Крылов В.В., Бородавина Е.В. Радиойодаблация при раке щитовидной железы. Исторические и современные аспекты. Обзор литературы. Онкологический журнал: лучевая диагностика, лучевая терапия 2021;4(4):9–19. DOI: 10.37174/2587-7593-2021-4-4-9-19</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><mixed-citation>Duren M., Siperstein A., Shen W. et al. Value of stimulated serum thyroglobulin levels for detecting persistent or recurrent differentiated thyroid cancer in high- and low-risk patients. Surgery 1999;26(1):13–9. DOI: 10.1067/msy.1999.98849</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Pacini F., Lippi F., Formica N. et al. Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels. J Nucl Med 1987;28(12):1888–91.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Pineda J., Lee T., Ain K. et al. Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J Clin Endocrinol Metab 1995;80(5):1488–92. DOI: 10.1210/ jcem.80.5.7744991</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Roelants V., De Nayer P., Bouckaert A., Beckers C. The predictive value of serum thyroglobulin in the follow-up of differentiated thyroid cancer. Eur J Nucl Med 1997;24:722–7. DOI: 10.1007/ BF00879658</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Pacini F., Molinaro E., Castagna M. et al. Ablation of thyroid residues with 30 mCi 131I: a comparison in thyroid cancer patients prepared with recombinant human TSH or thyroid hormone withdrawal. J Clin Endocrinol Metab 2002;87(9):4063–8. DOI: 10.1210/jc.2001-011918</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kukulska A., Krajewska J., Gawkowska-Suwiriska M. et al. Radioiodine thyroid remnant ablation in patients with differentiated thyroid carcinoma (DTC): prospective comparison of long-term outcomes of treatment with 30, 60, and 100 mCi. Thyroid Res 2010;3(1):9. DOI: 10.1186/1756-6614-3-9</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Toubeau M., Touzery C., Arveux P. et al. Predictive value for disease progression of serum thyroglobulin levels measured in the postoperative period and after 131I ablation therapy in patients with differentiated thyroid cancer. J Nucl Med 2004;45(6):988–94.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Haugen B., Alexander E., Bible K.C. et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26(1):1–133. DOI: 10.1089/thy.2015.0020</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Lamartina L., Grani G., Durante C., Filetti S. Recent advances in managing differentiated thyroid cancer. F1000Res 2018;7:86. DOI: 10.12688/f1000research.12811.1</mixed-citation></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Gray J., Singh G., Uttley L., Balasubramanian S. Routine thyroglobulin, neck ultrasound and physical examination in the routine follow up of patients with differentiated thyroid cancer: where is the evidence? Endocrine 2018;62(1):26–33. DOI: 10.1007/ s12020-018-1720-3</mixed-citation><mixed-citation xml:lang="ru">Gray J., Singh G., Uttley L., Balasubramanian S. Routine thyroglobulin, neck ultrasound and physical examination in the routine follow up of patients with differentiated thyroid cancer: where is the evidence? Endocrine 2018;62(1):26–33. DOI: 10.1007/s12020-018-1720-3</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Prpić M., Franceschi M., Romić M. et al. Thyroglobulin as a tumor marker in differentiated thyroid cancer – clinical considerations. Acta Clin Croat 2018;57(3):518–27. DOI: 10.20471/ acc.2018.57.03.16</mixed-citation><mixed-citation xml:lang="ru">Prpić M., Franceschi M., Romić M. et al. Thyroglobulin as a tumor marker in differentiated thyroid cancer – clinical considerations. Acta Clin Croat 2018;57(3):518–27. DOI: 10.20471/acc.2018.57.03.16</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><mixed-citation>Giovanella L., Clark P., Chiovato L. et al. Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer: a clinical position paper. Eur J Endocrinol 2014;171(2):R33–46. DOI: 10.1530/EJE-14-0148</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Spencer C. Clinical review: clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC). J Clin Endocrinol Metab 2011;96(12):3615–27. DOI: 10.1210/jc.2011-1740</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Dekker B., Van der Horst-Schrivers A., Brouwers A. et al. Clinical irrelevance of lower titer thyroglobulin autoantibodies in patients with differentiated thyroid carcinoma. Eur Thyroid J 2022 20;11(6):e220137. DOI: 10.1530/ETJ-22-0137</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Brassard M., Borget I., Edet-Sanson A. et al. Long-term follow-up of patients with papillary and follicular thyroid cancer: a prospective study on 715 patients. J Clin Endocrinol Metab 2011;96(5):1352–9. DOI: 10.1210/jc.2010-2708</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Durante C., Montesano T., Attard M. et al. Long-term surveillance of papillary thyroid cancer patients who do not undergo postoperative radioiodine remnant ablation: is there a role for serum thyroglobulin measurement? J Clin Endocrinol Metab 2012;97(8):2748–53. DOI: 10.1210/jc.2012-1123</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Angell T., Spencer C., Rubino B. et al. In search of an unstimulated thyroglobulin baseline value in low-risk papillary thyroid carcinoma patients not receiving radioactive iodine ablation. Thyroid 2014;24(7):1127–33. DOI: 10.1089/thy.2013.0691</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Grani G., Fumarola A. Thyroglobulin in lymph node fine-needle aspiration washout: a systematic review and meta-analysis of diagnostic accuracy. J Clin Endocrinol Metab 2014;99(6):1970–82. DOI: 10.1210/jc.2014-1098</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Torlontano M., Attard M., Crocetti U. et al. Follow-up of low risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting lymph node metastases. J Clin Endocrinol Metab 2004;89(7):3402–7. DOI: 10.1210/ jc.2003-031521</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Grani G., Lamartina L., Cantisani V. et al. Enterobserver agreement of various thyroid imaging reporting and data systems. Endocr Connect 2018;7(1):1–7. DOI: 10.1530/EC-17-0336</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Lamartina L., Grani G., Biffoni M. et al. Risk stratification of neck lesions detected sonographically during the follow-up of differentiated thyroid cancer. J Clin Endocrinol Metab 2016;101(8):3036–44. DOI: 10.1210/jc.2016-1440</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Leboulleux S., Girard E., Rose M. et al. Ultrasound criteria of malignancy for cervical lymph nodes in patients followed up for differentiated thyroid cancer. J Clin Endocrinol Metab 2007;92(9):3590–4. DOI: 10.1210/jc.2007-0444</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Leenhardt L., Erdogan M., Hegedus L. et al. 2013 European Thyroid Association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur Thyroid J 2013;2(3):147–59. DOI: 10.1159/000354537</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Lamartina L., Deandreis D., Durante C., Filetti S. ENDOCRINE TUMOURS: imaging in the follow-up of differentiated thyroid cancer: current evidence and future perspectives for a risk-adapted approach. Eur J Endocrinol 2016;175(5):R185–202. DOI: 10.1530/ EJE-16-0088</mixed-citation></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">Grani G., Ramundo V., Falcone R. et al. Thyroid cancer patients with no evidence of disease: the need for repeat neck ultrasound. J Clin Endocrinol Metab 2019;104(11):4981–9. DOI: 10.1210/ jc.2019-00962</mixed-citation><mixed-citation xml:lang="ru">Grani G., Ramundo V., Falcone R. et al. Thyroid cancer patients with no evidence of disease: the need for repeat neck ultrasound. J Clin Endocrinol Metab 2019;104(11):4981–9. DOI: 10.1210/jc.2019-00962</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><mixed-citation>Castagna M., Maino F., Cipri C. et al. Delayed risk stratification, to include the response to initial treatment (surgery and radioiodine ablation), has better outcome predictivity in differentiated thyroid cancer patients. Eur J Endocrinol 2011;165(3):441–6. DOI: 10.1530/EJE-11-0466</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Tuttle R., Tala H., Shah J. et al. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid 2010;20(12):1341–9. DOI: 10.1089/thy.2010.0178</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Durante C., Attard M., Torlontano M. et al. Identification and optimal postsurgical follow-up of patients with very low-risk papillary thyroid microcarcinomas. J Clin Endocrinol Metab 2010;95(11):4882–8. DOI: 10.1210/jc.2010-0762</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Castagna M., Maino F., Cipri C. et al. Delayed risk stratification, to include the response to initial treatment (surgery and radioiodine ablation), has better outcome predictivity in differentiated thyroid cancer patients. Eur J Endocrinol 2011;165(3):441–6. DOI: 10.1530/EJE-11-0466</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Tuttle R., Tala H., Shah J. et al. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid 2010; 20(12):1341–9. DOI: 10.1089/thy.2010.0178</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Jeon M., Kim W., Park W. et al. Modified dynamic risk stratification for predicting recurrence using the response to initial therapy in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2014;170:23–30. DOI: 10.1530/EJE-13-0524</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Han J., Kim W., Yim J. et al. Long-term clinical outcome of differentiated thyroid cancer patients with undetectable stimulated thyroglobulin level one year after initial treatment. Thyroid 2012;22(8):784–90. DOI: 10.1089/thy.2011.0322</mixed-citation></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">Scheffel R., Zanella A., Antunes D. et al. Low recurrence rates in a cohort of differentiated thyroid carcinoma patients: a referral center experience. Thyroid 2015;25(8):883–9. DOI: 10.1089/ thy.2015.0077</mixed-citation><mixed-citation xml:lang="ru">Scheffel R., Zanella A., Antunes D. et al. Low recurrence rates in a cohort of differentiated thyroid carcinoma patients: a referral center experience. Thyroid 2015;25(8):883–9. DOI: 10.1089/thy.2015.0077</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><mixed-citation>Llamas-Olier A., Cuéllar D., Buitrago G. Intermediate-risk papillary thyroid cancer: risk factors for early recurrence in patients with excellent response to initial therapy. Thyroid 2018;28(10):1311–7. DOI: 10.1089/thy.2017.0578</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Ganly I., Nixon I., Wang L. et al. Survival from differentiated thyroid cancer: what has age got to do with it? Thyroid 2015;25(10):1106–14. DOI: 10.1089/thy.2015.0104</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Comtois R., Theriault C., Del Vecchio P. Assessment of the efficacy of iodine-131 for thyroid ablation. J Nucl Med 1993;34(11):1927–30.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Schlumberger M., Berg G., Cohen O. et al. Follow-up of low-risk patients with differentiated thyroid carcinoma. Eur J Endocrinol 2004;150(2):105–12. DOI: 10.1530/eje.0.1500105</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Sacks W., Fung C., Chang J. et al. The effectiveness of radioactive iodine for treatment of low-risk thyroid cancer: a systematic analysis of the peer-reviewed literature from 1966 to April 2008. Thyroid 2010;20(11):1235–45. DOI: 10.1089/thy.2009.0455</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Dietlein M., Eschner W., Grünwald F. et al. Procedure guidelines for radioiodine therapy of differentiated thyroid cancer. Nuklearmedizin 2016;55:77–89. DOI: 10.1055/s-0037-1616478</mixed-citation></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">Gastanga M., Cantara S., Pacini F. Reappraisal of the indication for radioiodine thyroid ablation in differentiated thyroid cancer patients. J Endocrinol Invest 2016;39(10):1087–94. DOI: 10.1007/ s40618-016-0503-z</mixed-citation><mixed-citation xml:lang="ru">Gastanga M., Cantara S., Pacini F. Reappraisal of the indication for radioiodine thyroid ablation in differentiated thyroid cancer patients. J Endocrinol Invest 2016;39(10):1087–94. DOI: 10.1007/s40618-016-0503-z</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><mixed-citation>Deandreis D., Rubino C., Tala H. et al. Comparison of empiric versus whole-body-blood clearance dosimetry-based approach to radioactive iodine treatment in patients with metastases from differentiated thyroid cancer. J Nucl Med 2017;58(5):717–22. DOI: 10.2967/jnumed.116.179606</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Verburg F., Schmidt M., Kreissl M. et al. Procedural guideline for Iodine-131 whole-body scintigraphy in differentiated thyroid carcinoma (version 5). Nuklearmedizin 2019;58(3):228–41. DOI: 10.1055/a-0891-1839</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Giovanella L., Treglia G., Sadeghi R. et al. Unstimulated highly sensitive thyroglobulin in follow-up of differentiated thyroid cancer patients: a meta-analysis. J Clin Endocrinol Metab 2014;99(2):440– 7. DOI: 10.1210/jc.2013-3156</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Francis G., Waguespack S., Bauer A. et al. American Thyroid Association Guidelines Task Force Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid 2015;25(7):716–59. DOI: 10.1089/thy.2014.0460</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Li J., He Z., Bansal V., Hennessey J. Low iodine diet in differentiated thyroid cancer: a review. Clin Endocrinol (Oxf) 2016;84(1):3–12. DOI: 10.1111/cen.12846</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Campennì А., Barbaro D., Guzzo M. et al. Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts. Endocrine 2020;70(2):280–91. DOI: 10.1007/s12020-020-02418-x</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Feine U., Lietzenmayer R., Hanke J. et al. 18FDG whole-body PET in differentiated thyroid carcinoma. Flipflop in uptake patterns of 18FDG and 131I. [In German]. Nuklearmedizin 1995;34(4):127–34.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Feine U., Lietzenmayer R., Hanke J. et al. Fluorine-18-FDG and iodine-131-iodide uptake in thyroid cancer. J Nucl Med 1996;37(9):1468–72.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Asa S., Aksoy S., Vatankulu B. et al. The role of FDG-PET/CT in differentiated thyroid cancer patients with negative iodine-131 whole-body scan and elevated anti-Tg level. Ann Nucl Med 2014;28(10):970–9. DOI: 10.1007/s12149-014-0897-7</mixed-citation></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">Liu Y. The role of 18F-FDG PET/CT in the follow-up of welldifferentiated thyroid cancer with negative thyroglobulin but positive and/or elevated antithyroglobulin antibody. Nucl Med Commun 2016;37(6):577–82. DOI: 10.1097/MNM.0000000000000480</mixed-citation><mixed-citation xml:lang="ru">Liu Y. The role of 18F-FDG PET/CT in the follow-up of well-differentiated thyroid cancer with negative thyroglobulin but positive and/or elevated antithyroglobulin antibody. Nucl Med Commun 2016;37(6):577–82. DOI: 10.1097/MNM.0000000000000480</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">Ozkan E., Aras G., Kucuk N. Correlation of 18F-FDG PET/CT findings with histopathological results in differentiated thyroid cancer patients who have increased thyroglobulin or antithyroglobulin antibody levels and negative 131I whole-body scan results. Clin Nucl Med 2013;38(5):326–31. DOI: 10.1097/ RLU.0b013e318286827b</mixed-citation><mixed-citation xml:lang="ru">Ozkan E., Aras G., Kucuk N. Correlation of 18F-FDG PET/CT findings with histopathological results in differentiated thyroid cancer patients who have increased thyroglobulin or antithyroglobulin antibody levels and negative 131I whole-body scan results. Clin Nucl Med 2013;38(5):326–31. DOI: 10.1097/RLU.0b013e318286827b</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><mixed-citation>Liu M., Cheng L., Jin Y. et al. Predicting 131I-avidity of metastases from differentiated thyroid cancer using 18F-FDG PET/CT in postoperative patients with elevated thyroglobulin. Sci Rep 2018;8(1):4352. DOI: 10.1038/s41598-018-22656-4</mixed-citation></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">Silberstein E. The problem of the patient with thyroglobulin elevation but negative iodine scintigraphy: the TENIS syndrome. Semin Nucl Med 2011;41(2):113–20. DOI: 10.1053/j. semnuclmed.2010.10.002</mixed-citation><mixed-citation xml:lang="ru">Silberstein E. The problem of the patient with thyroglobulin elevation but negative iodine scintigraphy: the TENIS syndrome. Semin Nucl Med 2011;41(2):113–20. DOI: 10.1053/j.semnuclmed.2010.10.002</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><mixed-citation>Bartel C., Magerefteh S., Avram A. et al. Snmmi procedure standard for scintigraphy for differentiated thyroid cancer. J Nucl Med Technol 2020;48(3):202–9. DOI: 10.2967/jnmt.120.243626</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Avram А., Giovanella L., Greenspan B. et al. SNMMI procedure standard/eanm practice guideline for nuclear medicine evaluation and therapy of differentiated thyroid cancer: abbreviated version. J Nucl Med 2022;63(6):15N–35N.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Petranović P., Kreissl M., Campenni A. et al. SNMMI/EANM practice guideline vs. ETA Consensus Statement: differences and similarities in approaching differentiated thyroid cancer management-the EANM perspective. Eur J Nucl Med Mol Imaging 2022;49(12):3959–63. DOI: 10.1007/s00259-022-05935-1</mixed-citation></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">Giovanella L., Treglia G., Ceriani L., Verburg F. Detectable thyroglobulin with negative imaging in differentiated thyroid cancer patients. What to do with negative anatomical imaging and radioiodine scan? Nuklearmedizin 2014;53(1):1–10. DOI: 10.3413/ Nukmed-0618-13-08</mixed-citation><mixed-citation xml:lang="ru">Giovanella L., Treglia G., Ceriani L., Verburg F. Detectable thyroglobulin with negative imaging in differentiated thyroid cancer patients. What to do with negative anatomical imaging and radioiodine scan? Nuklearmedizin 2014;53(1):1–10. DOI: 10.3413/Nukmed-0618-13-08</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><mixed-citation>Van Nostrand D. Radioiodine imaging for differentiated thyroid cancer: not all radioiodine images are performed equally. Thyroid 2019;29(7):901–9.</mixed-citation></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">Donohoe K., Aloff J., Avram А. et al. Appropriate use criteria for nuclear medicine in the evaluation and treatment of differentiated thyroid cancer. J Nucl Med 2020;61(3):375–96. DOI: 10.2967/ jnumed.119.240945</mixed-citation><mixed-citation xml:lang="ru">Donohoe K., Aloff J., Avram А. et al. Appropriate use criteria for nuclear medicine in the evaluation and treatment of differentiated thyroid cancer. J Nucl Med 2020;61(3):375–96. DOI: 10.2967/jnumed.119.240945</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">Binse I., Poeppel T., Ruhlmann M. et al. 68Ga-DOTATOC PET/CT in patients with iodine- and 18F-FDG-negative differentiated thyroid carcinoma and elevated serum thyroglobulin. J Nucl Med 2016;57(10):1512–7. DOI: 10.2967/ jnumed.115.171942</mixed-citation><mixed-citation xml:lang="ru">Binse I., Poeppel T., Ruhlmann M. et al. 68Ga-DOTATOC PET/CT in patients with iodine- and 18F-FDG-negative differentiated thyroid carcinoma and elevated serum thyroglobulin. J Nucl Med 2016;57(10):1512–7. DOI: 10.2967/jnumed.115.171942</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><mixed-citation>Vrachimis A., Stegger L., Wenning C. et al. 68Ga-DOTATATE PET/ MRI and 18F-FDG PET/CT are complementary and superior to diffusion-weighted MR imaging for radioactive-iodine-refractory differentiated thyroid cancer. Eur J Nucl Med Mol Imaging 2016;43(10):1765–72. DOI: 10.1007/s00259-016-3378-5</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Czepczynski R., Matysiak-Grzes M., Gryczynska M. et al. Peptide receptor radionuclide therapy of differentiated thyroid cancer: efficacy and toxicity. Arch Immunol Ther Exp (Warsz) 2015;63(2):147–54. DOI: 10.1007/s00005-014-0318-6</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Versari A., Sollini M., Frasoldati A. et al. Differentiated thyroid cancer: A new perspective with radiolabeled somatostatin analogues for imaging and treatment of patients. Thyroid 2014;24(4):715–26. DOI: 10.1089/thy.2013.0225</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Roll W., Riemann B., Schafers M. et al. 177Lu-DOTATATE therapy in radioiodine-refractory differentiated thyroid cancer: a single center experience. Clin Nucl Med 2018;43(10):e346–51. DOI: 10.1097/RLU.0000000000002219</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Gubbi S., Koch C., Klubo-Gwiezdzinska J. Peptide receptor radionuclide therapy in thyroid cancer. Front endocrinol (Lausanne) 2022;13:896287. DOI: 10.3389/fendo.2022.896287</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Ryu Y.J., Lim S.Y., Na Y.M. et al. Prostate-specific membrane antigen expression predicts recurrence of papillary thyroid carcinoma after total thyroidectomy. BMC Cancer 2022;22(1):1278. DOI: 10.1186/s12885-022-10375-z</mixed-citation></ref><ref id="B72"><label>72.</label><citation-alternatives><mixed-citation xml:lang="en">Piek M., De Vries L., Donswijk M. et al. Ploeg IMC. Retrospective analysis of PSMA PET/CT thyroid incidental uptake in adults: incidence, diagnosis, and treatment/outcome in a tertiary cancer referral center and University Medical Center. Eur J Nucl Med Mol Imaging 2022;49(7):2392–400. DOI: 10.1007/s00259- 022-05679-y</mixed-citation><mixed-citation xml:lang="ru">Piek M., De Vries L., Donswijk M. et al. Ploeg IMC. Retrospective analysis of PSMA PET/CT thyroid incidental uptake in adults: incidence, diagnosis, and treatment/outcome in a tertiary cancer referral center and University Medical Center. Eur J Nucl Med Mol Imaging 2022;49(7):2392–400. DOI: 10.1007/s00259-022-05679-y</mixed-citation></citation-alternatives></ref></ref-list></back></article>
