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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">90</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2012-0-3-66-68</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE URGENCY OF THE PROBLEM OF RESIDUAL NEUROMUSCULAR BLOCK AFTER SINGLE INTRAOPERATIVE RELAXANT ADMINISTRATION IN NEUROSURGICAL PATIENTS: PRELIMINARY DATA</article-title><trans-title-group xml:lang="ru"><trans-title>АКТУАЛЬНОСТЬ ПРОБЛЕМЫ ОСТАТОЧНОЙ НЕРВНО-МЫШЕЧНОЙ БЛОКАДЫ ПОСЛЕ ОДНОКРАТНОГО ИНТРАОПЕРАЦИОННОГО ВВЕДЕНИЯ МИОРЕЛАКСАНТА У НЕЙРОХИРУРГИЧЕСКИХ БОЛЬНЫХ: ПРЕДВАРИТЕЛЬНЫЕ ДАННЫЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tseitlin</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Цейтлин</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>alzei@nsi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lubnin</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Лубнин</surname><given-names>А. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Salsayev</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Салсаев</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Salova</surname><given-names>E. M.</given-names></name><name xml:lang="ru"><surname>Салова</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Israyelyan</surname><given-names>L. A.</given-names></name><name xml:lang="ru"><surname>Исраелян</surname><given-names>Л. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Acad. N.N. Burdenko Neurosurgery Research Institute, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ФГБУ «НИИ нейрохирургии им. акад. Н.Н. Бурденко» РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2012</year></pub-date><volume>2</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>66</fpage><lpage>68</lpage><history><date date-type="received" iso-8601-date="2015-04-18"><day>18</day><month>04</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-04-18"><day>18</day><month>04</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Tseitlin A.M., Lubnin A.Y., Salsayev T.A., Salova E.M., Israyelyan L.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Цейтлин А.М., Лубнин А.Ю., Салсаев Т.А., Салова Е.М., Исраелян Л.А.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Tseitlin A.M., Lubnin A.Y., Salsayev T.A., Salova E.M., Israyelyan L.A.</copyright-holder><copyright-holder xml:lang="ru">Цейтлин А.М., Лубнин А.Ю., Салсаев Т.А., Салова Е.М., Исраелян Л.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/90">https://ogsh.abvpress.ru/jour/article/view/90</self-uri><abstract xml:lang="en"><p>Under the present-day conditions, it is necessary to allow for rapid postoperative awakening in each neurosurgical patient, which is impossible under residual neuromuscular block. The paper gives the preliminary data of a prospective observational study of the frequency of residual neuromuscular block after single intraoperative administration of a moderate- or long-acting myorelaxant. When the myorelaxants are used once according to the standard procedure (in the absence of TOF monitoring and pharmacological elimination of the action of myorelaxants), the rate of residual myorelaxation in neurosurgical patients has been found to be unacceptably high and to hinder their rapid awakening and neurological assessment. The administration of pipecuronium gives rise to residual block in all cases. That of rocuronium makes it possible to reduce the rate of residual myorelaxation, but not to eliminate it completely. Residual block can be preserved 2–4.5 hours after single administration of rocuronium or pipecuronium. </p></abstract><trans-abstract xml:lang="ru"><p>В современных условиях необходимо обеспечить возможность быстрого пробуждения после операции у каждого нейрохирургического больного, что невозможно в условиях остаточной нервно-мышечной блокады. Приведены предварительные данные проспективного обсервационного исследования частоты остаточной нервно-мышечной блокады после однократного интраоперационного введения миорелаксанта средней или большой продолжительности действия. Установлено, что при однократном применении миорелаксантов по стандартной методике (в отстутствие TOF-мониторинга и фармакологического устранения действия миорелаксантов) частота остаточной миорелаксации у нейрохирургических больных неприемлемо высока, препятствует быстрому пробуждению и оценке неврологического статуса. Применение пипекурония во всех случаях приводит к остаточной блокаде. Применение рокурония позволяет снизить частоту остаточной миорелаксации, но не устранить ее полностью. Остаточная блокада может сохраняться спустя 2–4,5 ч после однократного введения рокурония или пипекурония. </p></trans-abstract><kwd-group xml:lang="en"><kwd>residual neuromuscular block</kwd><kwd>early postoperative period</kwd><kwd>neurosurgical patients’ awakening</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>остаточная нервно-мышечная блокада</kwd><kwd>ранний послеоперационный период</kwd><kwd>пробуждение у нейрохирургических больных</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Debaene B., Plaud B., Dilly M.P. et al. Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action. 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