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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">913</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2023-13-3-43-50</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Orofacial pain in oncology: use of a new analgesic peptide tafalgin</article-title><trans-title-group xml:lang="ru"><trans-title>Орофациальная боль в онкологии: применение нового пептидного анальгетика тафалгина</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6146-2706</contrib-id><name-alternatives><name xml:lang="en"><surname>Abuzarova</surname><given-names>G. R.</given-names></name><name xml:lang="ru"><surname>Абузарова</surname><given-names>Г. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>3 2<sup>nd</sup> Botkinsky proezd, Moscow 125284,</italic></p><p><italic>Bld. 1, 2/1 Barricadnaya St., Moscow 125993</italic></p></bio><bio xml:lang="ru"><p><italic>125284 Москва, 2-й Боткинский проезд, 3,</italic></p><p><italic>125993 Москва, ул. Баррикадная, 2/1, стр. 1</italic></p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0727-5758</contrib-id><name-alternatives><name xml:lang="en"><surname>Sarmanaeva</surname><given-names>R. R.</given-names></name><name xml:lang="ru"><surname>Сарманаева</surname><given-names>Р. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Regina R. Sarmanaeva </bold></p><p><italic>3 2<sup>nd</sup> Botkinsky proezd, Moscow 125284,</italic></p><p><italic>Bld. 1, 2/1 Barricadnaya St., Moscow 125993</italic></p></bio><bio xml:lang="ru"><p><bold>Регина Рашитовна Сарманаева </bold></p><p><italic>125284 Москва, 2-й Боткинский проезд, 3,</italic></p><p><italic>125993 Москва, ул. Баррикадная, 2/1, стр. 1</italic></p></bio><email>r.sarm@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8204-9032</contrib-id><name-alternatives><name xml:lang="en"><surname>Alekseeva</surname><given-names>G. S.</given-names></name><name xml:lang="ru"><surname>Алексеева</surname><given-names>Г. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>4 Koroleva St., Obninsk 249036</italic></p></bio><bio xml:lang="ru"><p><italic>249036</italic><italic> </italic><italic>Обнинск,</italic><italic> </italic><italic>ул. Королева, 4</italic></p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5317-0394</contrib-id><name-alternatives><name xml:lang="en"><surname>Kuznetsov</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Кузнецов</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>3 2<sup>nd</sup> Botkinsky proezd, Moscow 125284</italic></p></bio><bio xml:lang="ru"><p><italic>125284 Москва, 2-й Боткинский проезд, 3</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9181-7811</contrib-id><name-alternatives><name xml:lang="en"><surname>Gevorkov</surname><given-names>A. R.</given-names></name><name xml:lang="ru"><surname>Геворков</surname><given-names>А. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>3 2<sup>nd</sup> Botkinsky proezd, Moscow 125284</italic></p></bio><bio xml:lang="ru"><p><italic>125284 Москва, 2-й Боткинский проезд, 3</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-0484-8414</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedorenko</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Федоренко</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>3 2<sup>nd</sup> Botkinsky proezd, Moscow 125284</italic></p></bio><bio xml:lang="ru"><p><italic>125284 Москва, 2-й Боткинский проезд, 3</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-2770-9921</contrib-id><name-alternatives><name xml:lang="en"><surname>Zaretskaya</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Зарецкая</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>3 2<sup>nd</sup> Botkinsky proezd, Moscow 125284</italic></p></bio><bio xml:lang="ru"><p><italic>125284 Москва, 2-й Боткинский проезд, 3</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">P.A. Herzen Moscow Oncology Research Institute – a branch of the National Medical Radiology Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Московский научно-исследовательский институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">National Medical Research Center of Radiology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-12" publication-format="electronic"><day>12</day><month>12</month><year>2023</year></pub-date><volume>13</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>43</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2023-12-11"><day>11</day><month>12</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-12-11"><day>11</day><month>12</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Abuzarova G.R., Sarmanaeva R.R., Alekseeva G.S., Kuznetsov S.V., Gevorkov A.R., Fedorenko N.A., Zaretskaya D.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Абузарова Г.Р., Сарманаева Р.Р., Алексеева Г.С., Кузнецов С.В., Геворков А.Р., Федоренко Н.А., Зарецкая Д.А.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Abuzarova G.R., Sarmanaeva R.R., Alekseeva G.S., Kuznetsov S.V., Gevorkov A.R., Fedorenko N.A., Zaretskaya D.A.</copyright-holder><copyright-holder xml:lang="ru">Абузарова Г.Р., Сарманаева Р.Р., Алексеева Г.С., Кузнецов С.В., Геворков А.Р., Федоренко Н.А., Зарецкая Д.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/913">https://ogsh.abvpress.ru/jour/article/view/913</self-uri><abstract xml:lang="en"><p>In patients with head and neck tumors severe pain is more common than in patients with malignant neoplasms of other locations. At a third of patients, pain is the first characteristic of the disease, and after diagnosis, one half of the patients are already having pain syndrome. Аntitumor treatment often not only bring relief, but can intensify pain, which can reduce wish to treated. Part of cancer survivor continue to experience. Thus, orofacial pain syndrome should be share depending on the mechanism of appearence and tactics of treatment on three periods: pain at the stage of diagnosis, then pain syndrome in process antitumor therapy and pain in remission. It is actually if it necessary to prescribe opioid analgesics, especially for a long time. Intensity of orofacial pain syndrome is usually strong and often need to prescribe opioid analgesics. Option to opioid analgesics may be a representative of a new group of analgetics – peptide analgesics – tafalgin. The mechanism of action is due to highly selective agonism to the m1-opioid receptors. The presented clinical example demonstrates the good analgesic effect of tafalgin and the possibility use as option to analgesics of the second stage of pain management.</p></abstract><trans-abstract xml:lang="ru"><p>У пациентов с опухолями головы и шеи сильная боль возникает чаще, чем у пациентов со злокачественными новообразованиями других локализаций. у 1/3 больных она является первым признаком заболевания, и к моменту постановки диагноза уже 50 % больных испытывают ее. противоопухолевая терапия зачастую не только не приносит облегчения, но может и усугубить боль, что снижает приверженность пациентов к лечению и ухудшает прогноз и качество жизни. Некоторые больные в стадии ремиссии продолжают испытывать боль как последствие проведенной терапии. В связи с этим орофациальный болевой синдром делят на 3 периода в зависимости от механизма его возникновения и тактики лечения: боль на этапе постановки диагноза, болевой синдром, обусловленный проводимой противоопухолевой терапией, и боль в стадии ремиссии. Выраженность орофациального болевого синдрома у большинства пациентов настолько высока, что требует назначения опиоидных анальгетиков. Их альтернативой может стать представитель новой группы обезболивающих препаратов – пептидных анальгетиков – тафалгин. механизм его действия обусловлен высокоселективным агонизмом к μ1-опиоидным рецепторам. представленный клинический пример демонстрирует хороший анальгетический эффект тафалгина и возможность его применения как альтернативы анальгетикам второй ступени обезболивания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>oncology</kwd><kwd>orofacial pain</kwd><kwd>opioid analgesics</kwd><kwd>tafalgin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>онкология</kwd><kwd>орофациальная боль</kwd><kwd>опиоидные анальгетики</kwd><kwd>тафалгин</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>van den Beuken–van Everdingen M.H., Hochstenbach L.M., Joosten E.A. et al. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain ymptom Manage 2016;51(6):1070–90. 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