Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press93710.17650/2222-1468-2023-13-4-58-64DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORSДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИMarkers of oncological prognosis in the surgical treatment of oral squamous cell carcinomaМаркеры онкологического прогноза при хирургическом лечении плоскоклеточного рака полости ртаhttps://orcid.org/0000-0002-0698-7710StukanA. I.СтуканьА. И.
Russian Federation

Anastasia Igorevna Stukan

350063; 4 Mitrofana Sedina St.; 197758; 68 Leningradskaya St.; Krasnodar; Saint Petersburg; Pesochny

Анастасия Игоревна Стукань

350063; ул. Митрофана Седина, 4; 197758; ул. Ленинградская, 68; Краснодар; Санкт-Петербург; Песочный

jolie86@bk.ruhttps://orcid.org/0000-0003-3089-5047KulbakinD. E.КульбакинД. Е.
Russian Federation

634009; 5 Kooperativny Line; Tomsk

634009; пер. Кооперативный, 5; Томск

https://orcid.org/0000-0002-4305-6691SemiglazovaT. Y.СемиглазоваТ. Ю.
Russian Federation

197758; 68 Leningradskaya St.; 191015; 41 Kirochnaya St.; Saint Petersburg; Pesochny

197758; ул. Ленинградская, 68; 191015; ул. Кирочная, 41; Санкт-Петербург; Песочный

https://orcid.org/0000-0001-6882-3896ShvaykovskayaYa. V.ШвейковскаяЯ. В.
Russian Federation

350040; 146 Dimitrova St.; Krasnodar

350040; ул. Димитрова, 146; Краснодар

https://orcid.org/0000-0002-5035-4486NefedovaE. A.НефедоваЕ. А.
Russian Federation

350040; 146 Dimitrova St.; Krasnodar

350040; ул. Димитрова, 146; Краснодар

AseevaI. I.АсееваИ. И.
Russian Federation

350040; 146 Dimitrova St.; Krasnodar

350040; ул. Димитрова, 146; Краснодар

Kuban State Medical University, Ministry of Health of the RussiaФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава РоссииN.N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова» Минздрава РоссииScientific Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of SciencesНаучно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»I.I. Mechnikov Northwestern State Medical University, Ministry of Health of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Минздрава РоссииClinical Oncological Dispensary No. 1, Ministry of Health of the Krasnodar TerritoryГБУЗ «Клинический онкологический диспансер № 1» Минздрава Краснодарского края3012202313458640604202406042024Copyright ©; 2023, Stukan A.I., Kulbakin D.E., Semiglazova T.Y., Shvaykovskaya Y.V., Nefedova E.A., Aseeva I.I.Copyright ©; 2023, Стукань А.И., Кульбакин Д.Е., Семиглазова Т.Ю., Швейковская Я.В., Нефедова Е.А., Асеева И.И.2023Stukan A.I., Kulbakin D.E., Semiglazova T.Y., Shvaykovskaya Y.V., Nefedova E.A., Aseeva I.I.Стукань А.И., Кульбакин Д.Е., Семиглазова Т.Ю., Швейковская Я.В., Нефедова Е.А., Асеева И.И.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/937

   The progression of head and neck squamous cell cancer (HNSCC) may be influenced by the characteristics of the local and systemic immune response, including the peculiarities of systemic inflammatory response during surgical interventions. The dependence of the prognosis of cancer patients on the preoperative general somatic status and postoperative complications is demonstrated precisely through the prism of a systemic inflammation development promoting the progression of oncological process. It is necessary to study the interaction of a typical inflammatory reaction and the features of reparative processes to understand the correct treatment strategy for patients with oral cancer in the conditions of the existing oncological process. It was found that chronization of inflammation is associated with m2-macrophage polarization which contributes to the tumor progression. And systemic inflammation indices correlate with treatment results. It is also necessary to identify prognostic factors of postoperative complications that affect the chronization of inflammation. They may include the general somatic and nutritional status of patients, concomitant diseases and indices of systemic inflammation. It is obvious that improving the results of surgical treatment of patients with oral cancer can be influenced by various ways of managing the inflammatory response, including the peculiarities of performing the reconstructive interventions and improving the preoperative general somatic and nutritional status.

   На прогрессирование опухолевого процесса при опухолях головы и шеи могут оказывать влияние характеристики локального и системного иммунного ответа, в том числе особенности развития системной воспалительной реакции при хирургических вмешательствах. Продемонстрирована зависимость прогноза пациентов со злокачественными новообразованиями от предоперационного общесоматического статуса и характера послеооперационных осложнений именно с учетом развития системной воспалительной реакции, провоцирующей рецидивирование и прогрессирование опухолевого процесса. Для выбора верной стратегии лечения больных раком полости рта необходимо изучить взаимодействие типичной воспалительной реакции и особенностей репаративных процессов в условиях онкологического процесса. Установлено, что хронизация воспалительной реакции, связанная с м2-поляризацией макрофагов, способствует прогрессированию опухолевого процесса, причем степень системного воспаления коррелирует с результатами лечения. Также необходимо выявлять факторы развития послеоперационных осложнений, влияющих на хронизацию воспаления. К ним могут относиться общесоматический статус и нутритивный статус пациентов, сопутствующие заболевания и индексы системного воспаления. Очевидно, что на улучшение результатов хирургического лечения больных раком полости рта при этих условиях способны повлиять различные способы управления воспалительной реакцией, в том числе особенности выполнения реконструктивно-пластического этапа, улучшение предоперационного общесоматического и нутритивного статусов.

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