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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">938</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2023-13-4-65-72</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОПУХОЛЕЙ ГОЛОВЫ И ШЕИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Reconstruction of midface defects after surgical treatment of skull base tumors</article-title><trans-title-group xml:lang="ru"><trans-title>Устранение дефектов средней зоны лица после хирургического лечения распространенных опухолей основания черепа</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2473-2671</contrib-id><name-alternatives><name xml:lang="en"><surname>Belov</surname><given-names>I. Yu.</given-names></name><name xml:lang="ru"><surname>Белов</surname><given-names>И. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>197758,; 68 Leningradskaya St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>197758;  ул. Ленинградская, 68; Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2446-4155</contrib-id><name-alternatives><name xml:lang="en"><surname>Primak</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Примак</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>197341; 2 Akkuratova St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>197341; ул. Аккуратова, 2; Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6138-3055</contrib-id><name-alternatives><name xml:lang="en"><surname>Samochernykh</surname><given-names>N. K.</given-names></name><name xml:lang="ru"><surname>Самочерных</surname><given-names>Н. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Nikita Alexandrovich Samochernykh</p><p>197341; 2 Akkuratova St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>Никита Александрович Самочерных</p><p>197341; ул. Аккуратова, 2; Санкт-Петербург</p></bio><email>nikitasam97@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7443-0500</contrib-id><name-alternatives><name xml:lang="en"><surname>Chizhova</surname><given-names>K. A.</given-names></name><name xml:lang="ru"><surname>Чижова</surname><given-names>К. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>197341; 2 Akkuratova St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>197341; ул. Аккуратова, 2; Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2857-8368</contrib-id><name-alternatives><name xml:lang="en"><surname>Kurnosov</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Курносов</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>197758,; 68 Leningradskaya St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>197758;  ул. Ленинградская, 68; Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chebotarev</surname><given-names>S. Ya.</given-names></name><name xml:lang="ru"><surname>Чеботарев</surname><given-names>С. Я.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>197341; 2 Akkuratova St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>197341; ул. Аккуратова, 2; Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5509-5612</contrib-id><name-alternatives><name xml:lang="en"><surname>Gulyaev</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Гуляев</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>197341; 2 Akkuratova St.; Saint Petersburg</p></bio><bio xml:lang="ru"><p>197341; ул. Аккуратова, 2; Санкт-Петербург</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N. N. Petrov National Medical Research Center of Oncology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">V. A. Almazov National Medical Research Centre</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-30" publication-format="electronic"><day>30</day><month>12</month><year>2023</year></pub-date><volume>13</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>65</fpage><lpage>72</lpage><history><date date-type="received" iso-8601-date="2024-04-06"><day>06</day><month>04</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-04-06"><day>06</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Belov I.Y., Primak N.A., Samochernykh N.K., Chizhova K.A., Kurnosov I.A., Chebotarev S.Y., Gulyaev D.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Белов И.Ю., Примак Н.А., Самочерных Н.К., Чижова К.А., Курносов И.А., Чеботарев С.Я., Гуляев Д.А.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Belov I.Y., Primak N.A., Samochernykh N.K., Chizhova K.A., Kurnosov I.A., Chebotarev S.Y., Gulyaev D.A.</copyright-holder><copyright-holder xml:lang="ru">Белов И.Ю., Примак Н.А., Самочерных Н.К., Чижова К.А., Курносов И.А., Чеботарев С.Я., Гуляев Д.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/938">https://ogsh.abvpress.ru/jour/article/view/938</self-uri><abstract xml:lang="en"><p><bold>   Aim. </bold>To perform a retrospective analysis of the results of surgical treatment of patients with anatomically widespread malignant skull base tumors and evaluate the possibility of using various types of closure of skull base defects.</p><p>  <bold> Materials and methods. </bold>The study is based on a retrospective analysis of medical records of 139 patients with midface tumors aged 14 to 77 years, operated from 1995 to 2023. Histological structure of the tumors was different. we divided all methods of reconstruction of midface defects into two groups. In the group 1, plastic closure of the defect was per-formed using flaps from anatomical areas located close to the defect. In the group 2, reconstruction was performed using flaps from distant anatomical areas.</p><p><bold>   Results. </bold>In the postoperative period, we did not observe gross cicatricial face deformities, impaired chewing and swallowing functions due to cicatricial contractures of chewing muscles. Titanium mesh for reconstruction was used in 68 (48.9 %) cases. The osteoperiosteal aponeurotic flap was used in 5 cases, of which in 3 (3.8 % of the total number of patients of the 1<sup>st</sup> group) – in combination with the temporal muscle. The thoracodorsal flap was used in 62 (44.6 %) patients. various methods of its movement and combination with the anterior dentate muscle were used. In 41 (66.1 %) cases, good cosmetic and functional results were obtained. These indicators correlated with adequate choice of reconstruction method allowing elimination of most of the impaired functions.</p><p><bold>   Conclusion. </bold>The use of the presented technologies for plastic closure of post-resection defects of various parts of the skull base, including those combined with extensive damage to the midface, leads to leveling of the cosmetic and functional consequences of surgical aggression.</p></abstract><trans-abstract xml:lang="ru"><p><bold>   Введение. </bold>Основной причиной возникновения послеоперационных дефектов средней зоны лица является хирургическое лечение злокачественных опухолей основания черепа с обширным экстракраниальным распространением. Эти новообразования имеют широкую инвазию, поэтому их необходимо удалять вместе с содержимым анатомических образований. Основной метод лечения таких опухолей – комбинированный с проведением радикальной операции.</p><p><bold>   Цель исследования</bold> – провести ретроспективный анализ результатов хирургического лечения больных с распространенными злокачественными опухолями основания черепа, оценить возможности применения различных видов пластического закрытия дефектов основания черепа.</p><p><bold>   Материалы и методы. </bold>Проведен ретроспективный анализ историй болезни 139 больных с опухолями средней зоны лица в возрасте от 14 до 77 лет, прооперированных за период с 1995 по 2023 гг. Радикальные операции выполнены по поводу различных по гистологической структуре новообразований. Все способы реконструкции дефектов средней зоны лица, возникших после удаления краниофациальных опухолей, мы разделили на 2 группы. В 1-й группе выполнялась пластика дефекта лоскутами с находящихся поблизости от дефекта анатомических зон, во 2-й группе – лоскутами с отдаленных анатомических зон.</p><p><bold>   Результаты.</bold> В послеоперационном периоде мы не наблюдали грубых рубцовых деформаций лица, нарушений функций жевания и глотания за счет рубцовых контрактур жевательной мускулатуры. Титановая сетка для реконструкции использовалась в 68 (48,9 %) случаях. Костно-надкостнично-апоневротический лоскут применялся в 5 случаях, из них в 3 (3,8 % от общего числа пациентов 1-й группы) – в сочетании с височной мышцей. у 62 (44,6 %) пациентов использовали торакодорзальный лоскут. При этом применяли различные методики его перемещения и комбинации с передней зубчатой мышцей. В 41 (66,1 %) случае получены хорошие косметические и функциональные результаты. Данные показатели коррелировали с адекватным выбором метода реконструкции, позволяющим устранить большинство нарушенных функций.</p><p><bold>   Заключение. </bold>Использование представленных технологий пластического закрытия пострезекционных дефектов различных отделов основания черепа, в том числе сочетающихся с обширным поражением средней зоны лица, приводит к нивелированию косметических и функциональных последствий хирургической агрессии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>reconstruction</kwd><kwd>craniofacial surgery</kwd><kwd>skull base tumors</kwd><kwd>midface defects</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>реконструкция</kwd><kwd>краниофациальная хирургия</kwd><kwd>опухоли основания черепа</kwd><kwd>дефекты средней зоны лица</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The work was performed without external funding</funding-statement><funding-statement xml:lang="ru">Работа выполнена без спонсорской поддержки</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Lund V.J., Stammberger H., Nicolai P. et al. 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