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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Head and Neck Tumors</journal-id><journal-title-group><journal-title xml:lang="en">Head and Neck Tumors</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли головы и шеи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2222-1468</issn><issn publication-format="electronic">2411-4634</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">943</article-id><article-id pub-id-type="doi">10.17650/2222-1468-2023-13-4-116-123</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The importance in clinical practice of the signal lymph node biopsy in squamous cell carcinoma of the head and neck</article-title><trans-title-group xml:lang="ru"><trans-title>Значимость в клинической практике биопсии сигнального лимфатического узла при плоскоклеточном раке кожи головы и шеи</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4496-6128</contrib-id><name-alternatives><name xml:lang="en"><surname>Gelfand</surname><given-names>I. M.</given-names></name><name xml:lang="ru"><surname>Гельфанд</surname><given-names>И. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Igor Mikhailovich Gelfand</p><p>115522; 24 Kashirskoye Shosse; Moscow</p></bio><bio xml:lang="ru"><p>Игорь Михайлович Гельфанд</p><p>115522; Каширское шоссе, 24; Москва</p></bio><email>igorgelf@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9132-3416</contrib-id><name-alternatives><name xml:lang="en"><surname>Kropotov</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Кропотов</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>115522; 24 Kashirskoye Shosse; Moscow</p></bio><bio xml:lang="ru"><p>115522; Каширское шоссе, 24; Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-7906-881X</contrib-id><name-alternatives><name xml:lang="en"><surname>Isaeva</surname><given-names>M. T.</given-names></name><name xml:lang="ru"><surname>Исаева</surname><given-names>М. Т.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>123995; 2 / 1 Barricadnaya St.; Moscow</p></bio><bio xml:lang="ru"><p>123995;  ул. Баррикадная 2 / 1; Москва</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1341-0765</contrib-id><name-alternatives><name xml:lang="en"><surname>Podvyaznikov</surname><given-names>S. O.</given-names></name><name xml:lang="ru"><surname>Подвязников</surname><given-names>С. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>123995; 2 / 1 Barricadnaya St.; Moscow</p></bio><bio xml:lang="ru"><p>123995;  ул. Баррикадная 2 / 1; Москва</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Russian Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-30" publication-format="electronic"><day>30</day><month>12</month><year>2023</year></pub-date><volume>13</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>116</fpage><lpage>123</lpage><history><date date-type="received" iso-8601-date="2024-04-07"><day>07</day><month>04</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-04-07"><day>07</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Gelfand I.M., Kropotov M.A., Isaeva M.T., Podvyaznikov S.O.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Гельфанд И.М., Кропотов М.А., Исаева М.Т., Подвязников С.О.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Gelfand I.M., Kropotov M.A., Isaeva M.T., Podvyaznikov S.O.</copyright-holder><copyright-holder xml:lang="ru">Гельфанд И.М., Кропотов М.А., Исаева М.Т., Подвязников С.О.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ogsh.abvpress.ru/jour/article/view/943">https://ogsh.abvpress.ru/jour/article/view/943</self-uri><abstract xml:lang="en"><p>   Skin cancer is the second most common tumor among non-melanoma malignant skin neoplasms, accounting for 20 % of cases. In the Russian federation in 2022, this pathology was identified in 79,124 people. The peak incidence occurs in the age range of 60–70 years. Considering the increasing life expectancy, the incidence of skin cancer is expected to rise. Despite the fact that regional metastases occur in 0.3–16 % of cases, the risk of metastasis can increase up to 48 % depending on high-risk factors. Since the presence of regional metastases is a key prognostic factor, special attention should be given to preventive interventions in the areas of regional metastasis.</p></abstract><trans-abstract xml:lang="ru"><p>   Рак кожи является второй по распространенности опухолью среди немеланомных злокачественных новообразований кожи и составляет 20 % случаев. В Российской Федерации в 2022 г. данная патология выявлена у 79 124 человек. Пик заболеваемости приходится на возраст 60–70 лет. С учетом роста продолжительности жизни заболеваемость раком кожи будет увеличиваться. Несмотря на то, что регионарные метастазы возникают в 0,3–16 % случаев, риск метастазирования может возрасти до 48 % в зависимости от факторов высокого риска. Поскольку наличие регионарных метастазов является основным прогностическим фактором, необходимо уделять особое внимание профилактическому воздействию на зоны регионарного метастазирования.</p></trans-abstract><kwd-group xml:lang="en"><kwd>squamous cell carcinoma of the scalp and neck</kwd><kwd>signal lymph nodes</kwd><kwd>biopsy of signal lymph node</kwd><kwd>regional metastases</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>плоскоклеточный рак кожи головы и шеи</kwd><kwd>сигнальные лимфатические узлы</kwd><kwd>биопсия сигнального лимфатического узла</kwd><kwd>регионарные метастазы</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The work was performed without external funding</funding-statement><funding-statement xml:lang="ru">Работа выполнена без спонсорской поддержки</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Lomas A., Leonardi-Bee J., Bath-Hextall F. 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