Head and Neck TumorsHead and Neck TumorsОпухоли головы и шеи2222-14682411-4634Publishing House ABV Press96810.17650/2222-1468-2024-14-1-49-55REVIEWОБЗОРНАЯ СТАТЬЯDiffuse midline glioma of the brainstem: genetic features, complications and treatment prospectsДиффузная срединная глиома ствола головного мозга: генетические особенности, сложности и перспективы леченияhttps://orcid.org/0000-0002-1505-2976KryanevA. M.КряневА. М.
Russian Federation

5 2nd Botkinsky Proezd, Moscow 125284

125284 Москва, 2-й Боткинский пр-д, 5

https://orcid.org/0000-0003-0626-5272RozanovI. D.РозановИ. Д.
Russian Federation

Ivan D. Rozanov.

5 2nd Botkinsky Proezd, Moscow 125284

Розанов Иван Дмитриевич.

125284 Москва, 2-й Боткинский пр-д, 5

oncolog.rozanov@yandex.ruhttps://orcid.org/0000-0001-5366-1281LebedevS. S.ЛебедевС. С.
Russian Federation

5 2nd Botkinsky Proezd, Moscow 125284; Bld. 1, 2 / 1 Barricadnaya St., Moscow 125993

125284 Москва, 2-й Боткинский пр-д, 5; 125993 Москва, ул. Баррикадная, 2 / 1, стр. 1

https://orcid.org/0000-0001-8391-1210GrekovD. N.ГрековД. Н.
Russian Federation

5 2nd Botkinsky Proezd, Moscow 125284; Bld. 1, 2 / 1 Barricadnaya St., Moscow 125993

125284 Москва, 2-й Боткинский пр-д, 5; 125993 Москва, ул. Баррикадная, 2 / 1, стр. 1

https://orcid.org/0000-0003-4460-9136TitovK. S.ТитовК. С.
Russian Federation

5 2nd Botkinsky Proezd, Moscow 125284; 6 Miklukho-Maklaya St., Moscow 117198

125284 Москва, 2-й Боткинский пр-д, 5; 117198 Москва, ул. Миклухо-Маклая, 6

https://orcid.org/0009-0005-2715-3933YakushevaT. A.ЯкушеваТ. А.
Russian Federation

5 2nd Botkinsky Proezd, Moscow 125284; 6 Miklukho-Maklaya St., Moscow 117198

125284 Москва, 2-й Боткинский пр-д, 5; 117198 Москва, ул. Миклухо-Маклая, 6

https://orcid.org/0009-0002-1562-8944SalpagarovM. Kh.СалпагаровМ. Х.
Russian Federation

5 2nd Botkinsky Proezd, Moscow 125284

125284 Москва, 2-й Боткинский пр-д, 5

S.P. Botkin City Clinical Hospital, Moscow Healthcare DepartmentГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииPeoples' Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»2806202414149550804202427062024Copyright ©; 2024, Kryanev A.M., Rozanov I.D., Lebedev S.S., Grekov D.N., Titov K.S., Yakusheva T.A., Salpagarov M.K.Copyright ©; 2024, Крянев А.М., Розанов И.Д., Лебедев С.С., Греков Д.Н., Титов К.С., Якушева Т.А., Салпагаров М.Х.2024Kryanev A.M., Rozanov I.D., Lebedev S.S., Grekov D.N., Titov K.S., Yakusheva T.A., Salpagarov M.K.Крянев А.М., Розанов И.Д., Лебедев С.С., Греков Д.Н., Титов К.С., Якушева Т.А., Салпагаров М.Х.https://creativecommons.org/licenses/by/4.0https://ogsh.abvpress.ru/jour/article/view/968

Diffuse midline glioma of the brain is a rare but very aggressive and resistant glial tumor. This pathology is characterized by impossibility of radical surgical treatment, radioresistance, resistance to drug treatment, high morbidity in children, low quality of life of the patients, frequent complications in the form of neurologic deficit, and unfavorable prognosis. The absence of effective treatment scheme for diffuse midline glioma requires identification of other methods (oncolytic virus therapy, immunotherapy) but there is not enough data on this topic leading to the necessity of its further investigation.

Диффузная срединная глиома головного мозга - редкая, но очень агрессивная и резистентная глиальная опухоль. Данная патология характеризуется невозможностью выполнения радикального хирургического лечения, радиорезистентностью, невосприимчивостью к лекарственной терапии, высокой детской заболеваемостью, низким качеством жизни пациентов, частым развитием осложнений в виде неврологического дефицита и неблагоприятным прогнозом. Отсутствие эффективной схемы лечения диффузной срединной глиомы головного мозга вызывает необходимость поиска альтернативных методов (терапия вирусами, иммунотерапия), однако данных по этой теме пока недостаточно, что требует ее дальнейшего изучения.

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