Markers of oncological prognosis in the surgical treatment of oral squamous cell carcinoma

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Abstract

   The progression of head and neck squamous cell cancer (HNSCC) may be influenced by the characteristics of the local and systemic immune response, including the peculiarities of systemic inflammatory response during surgical interventions. The dependence of the prognosis of cancer patients on the preoperative general somatic status and postoperative complications is demonstrated precisely through the prism of a systemic inflammation development promoting the progression of oncological process. It is necessary to study the interaction of a typical inflammatory reaction and the features of reparative processes to understand the correct treatment strategy for patients with oral cancer in the conditions of the existing oncological process. It was found that chronization of inflammation is associated with m2-macrophage polarization which contributes to the tumor progression. And systemic inflammation indices correlate with treatment results. It is also necessary to identify prognostic factors of postoperative complications that affect the chronization of inflammation. They may include the general somatic and nutritional status of patients, concomitant diseases and indices of systemic inflammation. It is obvious that improving the results of surgical treatment of patients with oral cancer can be influenced by various ways of managing the inflammatory response, including the peculiarities of performing the reconstructive interventions and improving the preoperative general somatic and nutritional status.

About the authors

A. I. Stukan

Kuban State Medical University, Ministry of Health of the Russia; N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: jolie86@bk.ru
ORCID iD: 0000-0002-0698-7710

Anastasia Igorevna Stukan

350063; 4 Mitrofana Sedina St.; 197758; 68 Leningradskaya St.; Krasnodar; Saint Petersburg; Pesochny

Russian Federation

D. E. Kulbakin

Scientific Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: fake@neicon.ru
ORCID iD: 0000-0003-3089-5047

634009; 5 Kooperativny Line; Tomsk

Russian Federation

T. Y. Semiglazova

N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia; I.I. Mechnikov Northwestern State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-4305-6691

197758; 68 Leningradskaya St.; 191015; 41 Kirochnaya St.; Saint Petersburg; Pesochny

Russian Federation

Ya. V. Shvaykovskaya

Clinical Oncological Dispensary No. 1, Ministry of Health of the Krasnodar Territory

Email: fake@neicon.ru
ORCID iD: 0000-0001-6882-3896

350040; 146 Dimitrova St.; Krasnodar

Russian Federation

E. A. Nefedova

Clinical Oncological Dispensary No. 1, Ministry of Health of the Krasnodar Territory

Email: fake@neicon.ru
ORCID iD: 0000-0002-5035-4486

350040; 146 Dimitrova St.; Krasnodar

Russian Federation

I. I. Aseeva

Clinical Oncological Dispensary No. 1, Ministry of Health of the Krasnodar Territory

Email: fake@neicon.ru

350040; 146 Dimitrova St.; Krasnodar

Russian Federation

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