Human papillomavirus-associated oropharyngeal carcinoma: trends in epidemiology and methods for detecting the virus in tumors

A. I. Stukan'; Стукань А. И.; O. Yu. Chukhray; Чухрай О. Ю.; V. A. Porkhanov; Порханов В. А.; R. A. Murashko; Мурашко Р. А.; V. N. Bodnya; Бодня В. H.; Yu. M. Makarova; Макарова Ю. М.

doi:10.17650/2222-1468-2018-8-3-77-83

Human papillomavirus-associated oropharyngeal carcinoma: trends in epidemiology and methods for detecting the virus in tumors

Authors: Stukan' A.I.¹^,2, Chukhray O.Y.³, Porkhanov V.A.⁴^,5, Murashko R.A.¹^,2, Bodnya V.N.⁴^,5, Makarova Y.M.³
Affiliations:
1. Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar Region
2. Kuban State Medical University, Ministry of Health of Russia.
3. Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar Region.
4. Kuban State Medical University, Ministry of Health of Russia
5. Scientific Research Institute – S. V. Ochapovsky Regional Clinical Hospital No. 1, Ministry of Health of the Krasnodar Region.
Issue: Vol 8, No 3 (2018)
Pages: 77-83
Section: REVIEW
Published: 07.11.2018
URL: https://ogsh.abvpress.ru/jour/article/view/364
DOI: https://doi.org/10.17650/2222-1468-2018-8-3-77-83
ID: 364

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Abstract

Oropharyngeal squamous cell carcinoma has been traditionally associated with tobacco and alcohol consumption. Nevertheless, latter 30 years have shown squamous cell carcinoma (OPSCC) incidence stagnation and increasing, despite the decrease in smoking prevalence. The incidence was recognized among white men of middle age, often non-smokers or former smokers in the investigations with smoking cessation data. It differs from traditional patient with OPSCC, older men, heavy smoker or alcohol drinker. The incidence of OPSCC is increased due human papilloma virus (HPV) infection. The infection transition is associated with sex and oro-genital contact may lead to HPV-infection of oropharynx and oral cavity. There are multiple types of HPV, but the majority of OPSCC is associated with HPV 16 type. Epidemiology of HPV-associated OPSCC, HPV-infection of oral cavity and/or oropharynx and HPV detection are discussed in the review.

Keywords

epidemiology, oropharyngeal squamous cell carcinoma, tonsillar carcinoma, human papilloma virus

About the authors

A. I. Stukan'

Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar Region; Kuban State Medical University, Ministry of Health of Russia.

Author for correspondence.
Email: jolie86@bk.ru
ORCID iD: 0000-0002-0698-7710

146 Dimitrova St., Krasnodar 350040;

4 Mitrofana Sedina St., Krasnodar 350063.

Russian Federation

O. Yu. Chukhray

Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar Region.

146 Dimitrova St., Krasnodar 350040. Russian Federation

V. A. Porkhanov

Kuban State Medical University, Ministry of Health of Russia; Scientific Research Institute – S. V. Ochapovsky Regional Clinical Hospital No. 1, Ministry of Health of the Krasnodar Region.

ORCID iD: 0000-0003-0572-1395

4 Mitrofana Sedina St., Krasnodar 350063;

167 1 Maya St., Krasnodar 350086.

Russian Federation

R. A. Murashko

Clinical Oncologic Dispensary No. 1, Ministry of Health of the Krasnodar Region; Kuban State Medical University, Ministry of Health of Russia.

146 Dimitrova St., Krasnodar 350040;

4 Mitrofana Sedina St., Krasnodar 350063.

Russian Federation

V. N. Bodnya

Kuban State Medical University, Ministry of Health of Russia; Scientific Research Institute – S. V. Ochapovsky Regional Clinical Hospital No. 1, Ministry of Health of the Krasnodar Region.

ORCID iD: 0000-0003-3169-9558

4 Mitrofana Sedina St., Krasnodar 350063;

167 1 Maya St., Krasnodar 350086.

Russian Federation