The necessity and advantages of personified neck lymph node dissection in T1-2N0M0 oral mucosa cancer. A pathway to radical surgery

Cover Page

Cite item

Full Text

Abstract

The study objective is to investigate the causes of insufficient efficiency of neck lymph node dissection and possibilities of its improvement in cancer of the oral mucosa without clinically detectable metastases.

Materials and methods. A review of literature on surgical methods of affecting regional lymph collectors in cancers of the oral cavity was performed, and preliminary data on possibilities of biopsy of the sentinel lymph node were obtained.

Conclusion. Combination of fluorescent lymph node mapping andflow cytometry allows to identify the sentinel lymph node and detect hidden micrometastases with high sensitivity.

About the authors

G. Margolin

Karolinska University Hospital, Karolinska Institute

Email: fake@neicon.ru
ORCID iD: 0000-0002-4693-2781
SE-171 77 Stockholm Sweden

A. М. Mudunov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-1255-5700

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

I. M. Gelfand

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: igorgelf@yandex.ru
ORCID iD: 0000-0002-4496-6128

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

Yu. V. Alymov

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-6851-9867

Build. 1, 2/1 Barrikadnaya St., Moscow 125993

Russian Federation

A. A. Akhundov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-9543-990X

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

S. О. Podvyaznikov

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-1341-0765

Build. 1, 2/1 Barrikadnaya St., Moscow 125993

Russian Federation

M. N. Narimanov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-1806-8401

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

T. N. Zabotina

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0001-7631-5699

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

E. N. Zakharova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-2790-6673

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

References

  1. Gel’fand I.M. Treatment tactics in patients with oral mucosa cancer, stage cT1—2N0M0. Dis. ... of cand. of med. sciences. Moscow, 2016. 187 p. (In Russ.).
  2. Ikram M., Jafferbhoy S.F., Onali M.A. Neck recurrence in early carcinoma tongue. J Pak Med Assoc 2006;56(10):448— 51. PMID: 17144391.
  3. Romanov I.S., Yakovleva L.P. Treatment of oral cancer. Farmateka = Pharmateca 2013;(8):21—5. (In Russ.).
  4. Gel’fand I. M., Romanov I.S., Udintsov D.B. Treatment policy for localized oral cancer. Opukholi golovy i shei = Head and Neck Tumors 2016;6(1):43—5. (In Russ.).
  5. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Head and neck cancers. Version 1.2018. Available at: http://oncolife.com.ua/doc/nccn/Head_and_Neck_Cancers.pdf
  6. Toker C. Some observations on the distribution of metastatic squamous carcinoma within cervical lymph nodes. Ann Surg 1963;157:419-26. PMID: 13985307.
  7. Ferlito A., Rinaldo A., Devaney K.O. et al. Detection of lymph node micrometastases in patients with squamous carcinoma of the head and neck. Eur Arch Otorhinolaryngol 2008;265(10):1147—53. doi: 10.1007/s00405-008-0715-8. PMID: 18523794.
  8. Al-Rajhi N., Khafaga Y., El-Husseiny J. et al. Early stage carcinoma of oral tongue: prognostic factors for local control and survival. Oral Oncology 2000;36(6): 508—14. PMID: 11036243.
  9. Ganly I., Patel S., Shah J. Early stage squamous cell cancer of the oral tongue — clinicopathologic features affecting outcome. Cancer 2012;118(1):101—11. doi: 10.1002/cncr.26229. PMID: 21717431.
  10. Ganly I., Goldstein D., Carlson D.L. et al. Long-term regional control and survival in patients with “low-risk” early stage oral tongue cancer managed by partial glossectomy and neck dissection without postoperative radiation tumor thickness in oral tongue cancer. Cancer 2013;119(6):1168—76. doi: 10.1002/cncr.27872. PMID: 23184439.
  11. D’Cruz A.K., Vaish R., Kapre N. et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 2015;373(6):521—9. doi: 10.1056/NEJMoa1506007. PMID: 26027881.
  12. Huang S.F., Kang C.J., Lin C.Y. et al. Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection. Cancer 2008;112(5):1066—75. doi: 10.1002/cncr.23278. PMID: 18246535.
  13. Shim S.J., Cha J., Koom W.S. et al. Clinical outcomes for T1—2N0—1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol 2010;5:43. doi: 10.1186/1748-717X-5-43. PMID: 20504371.
  14. So Y.K., Oh D., Choi N. et al. Efficacy of postoperative neck irradiation for regional control in patients with pN0 oral tongue cancer: propensity analysis. Head Neck 2018;40(1):163—9. doi: 10.1002/hed.24980. PMID: 29083541.
  15. Falileev G.V. Methodical instructions to the operation of removal of lymph nodes and neck tissue in cancer of the tongue and lower lip. In: Methodical letters on the diagnosis and treatment of cancer of some localizations. Moscow, 1963. Pp. 23-30. (In Russ.).
  16. Bocca E., Pignataro O. A conservation technique in radical neck dissection. Ann Otol Rhinol Laryngol 1967;76(5):975-87. doi: 10.1177/000348946707600508. PMID: 6074244.
  17. Suarez O. El problema de las metastasis linfaticas y alejadas del cancer de laringe e hipofaringe. Rev Otorrinolaringol (Santiago de Chile) 1963;23:83-99.
  18. Robbins K.T., Samant S., Ronen O. Neck dissection. In: Cummings otolaryngology: head & neck surgery. Ed. by P.W. Flint, B.H. Haughey, L.J. Lund et al. 5th edn. Philadelphia: Elsevier Mosby, 2010.
  19. Chu W., Strawitz J.G. Results in suprahyoid, modified radical, and standard radical neck dissections for metastatic squamous cell carcinoma: recurrence and survival. Am J Surg 1978;136(4):512—5. PMID: 707733.
  20. Byers R.M., Weber R.S., Andrews T. et al. Frequency and therapeutic implications of “skip metastases” in the neck from squamous carcinoma of the oral tongue. Head Neck 1997;19(1):14-9. PMID: 9030939.
  21. Rouviere H. Lymphatic system of the head and neck. In: Anatomy of the human lymphatic system. Ed. by M.J. Tobias. Ann Arbor: Edwards Brothers, 1938. Pp. 5-28.
  22. Brierley J. The evolving TNM cancer staging system: an essential component of cancer care. CMAJ 2006;174(2):155-6. doi: 10.1503/cmaj.045113. PMID: 16415456.
  23. Van den Brekel M.W., Stel H.V., Castelijns J.A. et al. Cervical lymph node metastasis: assessment of radiologic criteria. Radiology 1990;177(2):379—84. doi: 10.1148/radiology.177.2.2217772. PMID: 2217772.
  24. Van den Brekel M.W., Stel H.V., van der Valk P. et al. Micrometastases from squamous cell carcinoma in neck dissection specimens. Eur Arch Otorhinolaryngol 1992;249(6):349-53. PMID: 1384570.
  25. Van den Brekel M.W., van der Waal I., Meijer C.J. et al. The incidence of micrometastases in neck dissection specimens obtained from elective neck dissections. Laryngoscope 1996;106(8):987-91. PMID: 8699914.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 36990 от  21.07.2009.