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Опухоли головы и шеи

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Анапластический рак щитовидной железы. Есть ли свет в конце туннеля?

https://doi.org/10.17650/2222-1468-2020-10-1-10-19

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Аннотация

Анапластический рак щитовидной железы – одна из самых прогностически неблагоприятных опухолей. Такой прогноз обусловлен быстрым увеличением размеров первичной опухоли с тенденцией к развитию асфиксии и быстрым появлением отдаленных метастазов, а также низкой эффективностью рекомендованных схем лечения. Эти схемы, ставшие результатом многолетних усилий онкологов всего мира и включающие в идеальном варианте хирургическое вмешательство, химиотерапию и лучевую терапию, не дают удовлетворительных результатов, а продолжительность жизни пациента после их применения нельзя назвать достаточной. Развитие представлений о молекулярно-генетических особенностях опухолей, в том числе анапластического рака щитовидной железы, предоставило нам информацию о двух возможных особенностях генетического аппарата опухолевых клеток, имеющих, предположительно, клиническое значение: мутации V600E в гене BRAF и слиянии генов NTRK. Описанный в данной статье клинический случай как раз послужит, вероятно, первой в России иллюстрацией эффективности анти-BRAF-терапии у пациентки с анапластическим раком щитовидной железы. С нашей точки зрения, польза данного примера заключается в демонстрации не только эффективности современной таргетной терапии, но и отсутствия необходимости отказываться от иных методов лечения, в данном случае от облучения области первичной опухоли (а в других случаях, по аналогии с этим, – и от хирургического удаления опухоли при условии ее резектабельности).

Об авторах

А. Л. Пылев
ООО «Центр инновационных медицинских технологий»
Россия
115191 Москва, Духовской пер., 22б


А. А. Жандарова
ООО «Центр инновационных медицинских технологий»
Россия
115191 Москва, Духовской пер., 22б


К. С. Петров
ООО «Медскан»
Россия
125195 Москва, Ленинградское шоссе, 47


Д. С. Романов
ООО «Центр инновационных медицинских технологий»; ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России
Россия

Денис Сергеевич Романов 

115191 Москва, Духовской пер., 22б


В. А. Лисовой
ООО «Центр инновационных медицинских технологий»
Россия
115191 Москва, Духовской пер., 22б


С. В. Голуб
ООО «Медскан»
Россия
125195 Москва, Ленинградское шоссе, 47


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Для цитирования:


Пылев А.Л., Жандарова А.А., Петров К.С., Романов Д.С., Лисовой В.А., Голуб С.В. Анапластический рак щитовидной железы. Есть ли свет в конце туннеля? Опухоли головы и шеи. 2020;10(1):10-19. https://doi.org/10.17650/2222-1468-2020-10-1-10-19

For citation:


Pylev A.L., Zhandarova A.A., Petrov K.S., Romanov D.S., Lisovoy V.A., Golub S.V. Anaplastic thyroid cancer. Is there a light at the end of the tunnel? Head and Neck Tumors (HNT). 2020;10(1):10-19. (In Russ.) https://doi.org/10.17650/2222-1468-2020-10-1-10-19

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