Preview

Опухоли головы и шеи

Расширенный поиск

Оральные мукозиты у пациентов с онкологической патологией орофарингеальной области: обзор литературы

https://doi.org/10.17650/2222-1468-2020-10-3-72-80

Полный текст:

Аннотация

Оральный мукозит – одно из наиболее частых последствий химиолучевой терапии у пациентов с раком орофарингеальной области. Именно развитие орального мукозита считается основной причиной прерывания противоопухолевой терапии, которое значительно ухудшает результаты лечения онкологического заболевания. Несмотря на то что заболевание хорошо изучено, на сегодняшний день не разработан универсальный общепринятый алгоритм его лечения и профилактики. В данном обзоре представлен анализ научных публикаций, посвященных проблемам этиологии, патогенеза, клинической картины, диагностики, лечения и профилактики орального мукозита.

Об авторах

А. О. Ерёмина
ФГАОУ ВО «Российский университет дружбы народов»
Россия

Александра Олеговна Ерёмина

117198 Москва, ул. Миклухо-Маклая, 6

 



И. А. Задеренко
ФГАОУ ВО «Российский университет дружбы народов»; ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия

117198 Москва, ул. Миклухо-Маклая, 6, 

115478 Москва, Каширское шоссе, 24



С. Ю. Иванов
ФГАОУ ВО «Российский университет дружбы народов»; ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России
Россия

117198 Москва, ул. Миклухо-Маклая, 6, 

119991 Москва, ул. Большая Пироговская, 2, стр. 4



С. Б. Алиева
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия

115478 Москва, Каширское шоссе, 24



А. Б. Дымников
ФГАОУ ВО «Российский университет дружбы народов»
Россия

117198 Москва, ул. Миклухо-Маклая, 6



А. В. Хромушина
ФГАОУ ВО «Российский университет дружбы народов»
Россия

117198 Москва, ул. Миклухо-Маклая, 6



Б. Г. Пхешхова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия

115478 Москва, Каширское шоссе, 24



Список литературы

1. Злокачественные новообразования в России в 2018 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена, 2019. 250 с. Доступно по: https://glavonco.ru/cancer_register/Забол_2018_Электр.pdf.

2. Канаев С.В. Принципы и обоснование химиолучевого лечения злокачественных опухолей. Практическая онкология 2008;9(1):1–8.

3. Langendijk J.A., Leemans C.R., Buter J. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a metaanalysis of the published literature. J Clin Oncol 2004;22(22):4604–12. DOI: 10.1200/JCO.2004.10.074.

4. Trotti A., Bellm L.A., Epstein J.B. et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol 2003;66(3):253–62. DOI: 10.1016/s0167-8140(02)00404-8.

5. Sonis S.T. Efficacy of palifermin (keratinocyte growth factor-1) in the amelioration of oral mucositis. Core Evid 2010;4:199–205. DOI: 10.2147/ce.s5995.

6. Sonis S., Clark J. Prevention and management of oral mucositis induced by antineoplastic therapy. Oncology (Williston Park) 1991;5(12):11–22.

7. Sonis S.T. The pathobiology of mucositis. Nat Rev Cancer 2004;4(4):277–84. DOI: 10.1038/nrc1318.

8. Gruber S., Dörr W. Tissue reactions to ionizing radiation – oral mucosa. Mutat Res 2016;770(Pt B):292–8. DOI: 10.1016/j.mrrev.2016.07.007.

9. Dörr W., Schmidt M. Normal tissue radiobiology. In: Comprehensive biomedical physics. Elsevier, 2014. Pp. 75–95.

10. Elting L.S., Keefe D.M., Sonis S.T. et al. Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life. Cancer 2008;113(10):2704–13. DOI: 10.1002/cncr.23898.

11. Elad S., Zadik Y. Chronic oral mucositis after radiotherapy to the head and neck: a new insight. Support Care Cancer 2016;24(11):4825–30. DOI: 10.1007/s00520-016-3337-5.

12. Elting L.S., Cooksley C., Chambers et al. The burdens of cancer therapy: clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 2003;98(7):1531–9. DOI: 10.1002/cncr.11671.

13. Peterson D.E., Doerr W., Hovan A. et al. Osteoradionecrosis in cancer patients: the evidence base for treatment-dependent frequency, current management strategies, and future studies. Support Care Cancer 2010;18(8):1089–98. DOI: 10.1007/s00520-010-0898-6.

14. Al-Dasooqi N., Sonis S.T., Bowen J.M. et al. Emerging evidence on the pathobiology of mucositis. Support Care Cancer 2013;21(7):2075–83. DOI: 10.1007/s00520-013-1810-y.

15. Elting L.S., Cooksley C.D., Chambers M.S., Garden A.S. Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys 2007;68(4):1110–20. DOI: 10.1016/j.ijrobp.2007.01.053.

16. Ferretti G.A., Ash R.C., Brown A.T. et al. Control of oral mucositis and candidiasis in marrow transplantation: a prospective, double-blind trial of chlorhexidine digluconate oral rinse. Bone Marrow Transplant 1988;3(5):483–93.

17. Rapoport A.P., Miller Watelet L.F., Linder T. et al. Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants. J Clin Oncol 1999;17(8):2446–53. DOI: 10.1200/JCO.1999.17.8.2446.

18. Wingard J.R., Merz W.G., Rinaldi M.G. et al. Increase in Candida Krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N Engl J Med 1991;325(18):1274–7. DOI: 10.1056/NEJM199110313251803.

19. Parulekar W., Mackenzie R., Bjarnason G., Jordan R.C. Scoring oral mucositis. Oral Oncology 1998;34(1):63–71. DOI: 10.1016/s1368-8375(97)00065-1.

20. Sonis S.T., Elting L.S., Keefe D. et al. Perspectives on cancer therapy-induced mucosal injury. Cancer 2004;100(9 Suppl): 1995–2025. DOI: 10.1002/cncr.20162.

21. Maria O.M., Eliopoulos N., Muanza T. Radiation-induced oral mucositis. Front Oncol 2017;7:89. DOI: 10.3389/fonc.2017.00089.

22. Gholizadeh N., Sheykhbahaei N., Sadrzadeh-Afshar M.-S. New treatment approaches of oral mucositis: a review of literature. Adv Hum Biol 2016;6(2):66.

23. Traktama D.O., Sufiawati I. Oral mucositis severity in patient with head and neck cancer undergoing chemotherapy and/or radiotherapy. Majalah Kedokteran Gigi Indonesia 2018;4(1):52.

24. Rubenstein E.B., Peterson D.E., Schubert M. et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 2004;100(9 Suppl):2026–46. DOI: 10.1002/cncr.20163.

25. Keefe D.M., Schubert M.M., Elting L.S. et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 2007;109(5):820–31. DOI: 10.1002/cncr.22484.

26. Lalla R.V., Bowen J., Barasch A. et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2014;120(10):1453–61. DOI: 10.1002/cncr.28592.

27. Cheng K.K.F., Chang A.M., Yuen M.P. Prevention of oral mucositis in paediatric patients treated with chemotherapy: a randomised crossover trial comparing two protocols of oral care. Eur J Cancer 2004;40(8):1208–16. DOI: 10.1016/j.ejca.2003.10.023.

28. Choi S.E., Kim H.S. Sodium bicarbonate solution versus chlorhexidine mouthwash in oral care of acute leukemia patients undergoing induction chemotherapy: a randomized controlled trial. Asian Nurs Res (Korean Soc Nurs Sci) 2012;6(2):60–6. DOI: 10.1016/j.anr.2012.05.004.

29. Diaz-Sanchez R.M., Pachón-Ibáñez J., Marín-Conde F. et al. Double-blind, randomized pilot study of bioadhesive chlorhexidine gel in the prevention and treatment of mucositis induced by chemoradiotherapy of head and neck cancer. Med Oral Patol Oral Cir Bucal 2015;20(3):e378–85. DOI: 10.4317/medoral.20338.

30. Dodd M.J., Dibble S.L., Miaskowski C. et al. Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapyinduced mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90(1):39–47. DOI: 10.1067/moe.2000.105713.

31. Epstein J.B., Vickars L., Spinelli J., Reece D. Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation. Oral Surg Oral Med Oral Pathol 1992;73(6):682–9. DOI: 10.1016/0030-4220(92)90009-f.

32. Ferretti G.A., Raybould T.P., Brown A.T. et al. Chlorhexidine prophylaxis for chemotherapy-and radiotherapy-induced stomatitis: a randomized double-blind trial. Oral Surg Oral Med Oral Pathol 1990;69(3):331–8. DOI: 10.1016/0030-4220(90)90295-4.

33. Foote R.L., Loprinzi C.L., Frank A.R. et al. Randomized trial of a chlorhexidine mouthwash for alleviation of radiationinduced mucositis. J Clin Oncol 1994;12(12):2630–3. DOI: 10.1200/JCO.1994.12.12.2630.

34. Kin-Fong Cheng K., Ka Tsui Yuen J. A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer. Cancer Nurs 2006;29(5):423–30. DOI: 10.1097/00002820-200609000-00012.

35. Madan Kumar P.D., Sequeira P.S., Shenoy K., Shetty J. The effect of three mouthwashes on radiation-induced oral mucositis in patients with head and neck malignancies: a randomized control trial. J Cancer Res Ther 2008;4(1):3–8. DOI: 10.4103/0973-1482.39597.

36. Mehdipour M., Taghavi Zenoz A., Asvadi Kermani I., Hosseinpour A. A comparison between zinc sulfate and chlorhexidine gluconate mouthwashes in the prevention of chemotherapy-induced oral mucositis. Daru 2011;19(1):71–3.

37. Mutters N.T., Neubert T.R., Nieth R., Mutters R. The role of Octenidol®, Glandomed® and chlorhexidine mouthwash in the prevention of mucositis and in the reduction of the oropharyngeal flora: a double-blind randomized controlled trial. GMS Hyg Infect Control 2015;10:Doc05. DOI: 10.3205/dgkh000248.

38. Pitten F.A., Kiefer T., Buth C. et al. Do cancer patients with chemotherapyinduced leukopenia benefit from an antiseptic chlorhexidine-based oral rinse? A double-blind, block-randomized, controlled study. J Hosp Infect 2003;53(4): 283–91. DOI: 10.1053/jhin.2002.1391.

39. Raether D., Walker P.O., Bostrum B., Weisdorf D. Effectiveness of oral chlorhexidine for reducing stomatitis in a pediatric bone marrow transplant population. Pediatr Dent 1989;11(1):37–42.

40. Roopashri G., Jayanthi K., Guruprasad R. Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: a drug trail. Contemp Clin Dent 2011;2(1):8–12. DOI: 10.4103/0976-237X.79292.

41. Samaranayake L.P., Robertson A.G., MacFarlane T.W. et al. The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clin Radiol 1988;39(3):291–4. DOI: 10.1016/s0009-9260(88)80538-5.

42. Sorensen J.B., Skovsgaard T., Bork E. et al. Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracil-based chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer 2008;112(7): 1600–6. DOI: 10.1002/cncr.23328.

43. Spijkervet F.K.L., van Saene H.K., Panders A.K. et al. Effect of chlorhexidine rinsing on the oropharyngeal ecology in patients with head and neck cancer who have irradiation mucositis. Oral Surg Oral Med Oral Pathol 1989;67(2):154–61.

44. Milstone A.M., Passaretti C.L., Perl T.M. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46(2):274–81. DOI: 10.1086/524736.

45. Weisdorf D.J., Bostrom B., Raether D. et al. Oropharyngeal mucositis complicating bone marrow transplantation: prognostic factors and the effect of chlorhexidine mouth rinse. Bone Marrow Transplant 1989;4(1):89–95.

46. McGaw W.T., Belch A. Oral complications of acute leukemia: Prophylactic impact of a chlorhexidine mouth rinse regimen. Oral Surg Oral Med Oral Pathol 1985;60(3):275–80. DOI: 10.1016/0030-4220(85)90311-1.

47. Feber T. Management of mucositis in oral irradiation. Clin Oncol (R Coll Radiol) 1996;8(2):106–11. DOI: 10.1016/s0936-6555(96)80116-6.

48. Hong C.H.L., Gueiros L.A., Fulton J.S. et al. Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 2019;27(10):3949–67. DOI: 10.1007/s00520-019-04848-4.

49. Saito H., Watanabe Y., Sato K. et al. Effects of professional oral health care on reducing the risk of chemotherapyinduced oral mucositis. Support Care Cancer 2014;22(11):2935–40. DOI: 10.1007/s00520-014-2282-4.

50. Vokurka S., Bystrická E., Koza V. et al. The comparative effects of povidoneiodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT – results of a randomized multicentre study. Support Care Cancer 2005;13(7):554–8. DOI: 10.1007/s00520-005-0792-9.

51. Gürgan C.A., Özcan M., Karakuş Ö. et al. Periodontal status and post-transplantation complications following intensive periodontal treatment in patients underwent allogenic hematopoietic stem cell transplantation conditioned with myeloablative regimen. Int J Dent Hyg 2013;11(2):84–90. DOI: 10.1111/j.1601-5037.2012.00550.x.

52. Kashiwazaki H., Matsushita T., Sugita J. et al. Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support Care Cancer 2012;20(2):367–73. DOI: 10.1007/s00520-011-1116-x.

53. Kubota K., Kobayashi W., Sakaki H. et al. Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer. Support Care Cancer 2015;23(11):3323–9. DOI: 10.1007/s00520-015-2774-x.

54. Santos P.S., Coracin F.L., Barros J.C. et al. Impact of oral care prior to HSCT on the severity and clinical outcomes of oral mucositis. Clin Transplant 2011;25(2):325–8. DOI: 10.1111/j.1399-0012.2010.01283.x.

55. Yokota T., Tachibana H., Konishi T. et al. Multicenter phase II study of an oral care program for patients with head and neck cancer receiving chemoradiotherapy. Support Care Cancer 2016;24(7):3029–36. DOI: 10.1007/s00520-016-3122-5.

56. Leppla L., De Geest S., Fierz K. An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study. Support Care Cancer 2016;24(2):773–82. DOI: 10.1007/s00520-015-2843-1.

57. Schmidt H., Boese S., Bauer A. et al. Interdisciplinary care programme to improve self-management for cancer patients undergoing stem cell transplantation: a prospective nonrandomised intervention study. Eur J Cancer Care (Engl) 2017;26(4). DOI: 10.1111/ecc.12458.

58. Yavuz B., Bal Yılmaz H. Investigation of the effects of planned mouth care education on the degree of oral mucositis in pediatric oncology patients. J Pediatr Oncol Nurs 2015;32(1):47–56. DOI: 10.1177/1043454214554011.

59. Ariyawardana A., Cheng K.K.F., Kandwal A. et al. Systematic review of antiinflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 2019;27(10):3985–95. DOI: 10.1007/s00520-019-04888-w.

60. Yasuda T., Chiba H., Satomi T. et al. Preventive effect of rebamipide gargle on chemoradiotherpy-induced oral mucositis in patients with oral cancer: a pilot study. J Oral Maxillofac Res 2011;2(4):e3. DOI: 10.5037/jomr.2011.2403.

61. Lalla R.V., Choquette L.E., Curley K.F. et al. Randomized double-blind placebocontrolled trial of celecoxib for oral mucositis in patients receiving radiation therapy for head and neck cancer. Oral Oncol 2014;50(11):1098–103. DOI: 10.1016/j.oraloncology.2014.08.001.

62. Nomura M., Kamata M., Kojima H. et al. Irsogladine maleate reduces the incidence of fluorouracil-based chemotherapy-induced oral mucositis. Ann Oncol 2013;24(4): 1062–6. DOI: 10.1093/annonc/mds584.

63. Dueñas-Gonzalez A., Sobrevilla-Calvo P., Frias-Mendivil M. et al. Misoprostol prophylaxis for high-dose chemotherapyinduced mucositis: a randomized doubleblind study. Bone Marrow Transplant 1996;17(5):809–12.

64. Hanson W.R., Marks J.E., Reddy S.P. et al. Protection from radiation-induced oral mucositis by a mouth rinse containing the prostaglandin E1 analog, misoprostol: a placebo controlled double blind clinical trial. Adv Exp Med Biol 1997;400(B):811–8.

65. Lalla R.V., Gordon G.B., Schubert M. et al. A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy. Support Care Cancer 2012;20(8):1797–804. DOI: 10.1007/s00520-011-1277-7.

66. Veness M.J., Foroudi F., Gebski V. et al. Use of topical misoprostol to reduce radiation-induced mucositis: results of a randomized, double-blind, placebocontrolled trial. Australas Radiol 2006;50(5):468–74. DOI: 10.1111/j.1440-1673.2006.01628.x.

67. Saunders D.P., Epstein J.B., Elad S. et al. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer 2013;21(11):3191–207. DOI: 10.1007/s00520-013-1871-y.

68. Migliorati C., Hewson I., Lalla R.V. et al. Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients. Support Care Cancer 2013;21(1):333–41. DOI: 10.1007/s00520-012-1605-6.

69. Zadik Y., Arany P.R., Fregnani E.R. et al. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 2019;27(10):3969–83. DOI: 10.1007/s00520-019-04890-2.

70. Antunes H.S., Herchenhorn D., Small I.A. et al. Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation. Radiother Oncol 2013;109(2):297–302. DOI: 10.1016/j.radonc.2013.08.010.

71. Gautam A.P., Fernandes D.J., Vidyasagar M.S. et al. Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy – a randomized controlled trial. Support Care Cancer 2013;21(5):1421–8. DOI: 10.1007/s00520-012-1684-4.

72. Gouvêa De Lima A., Villar R.C., de Castro G. Jr et al. Oral mucositis prevention by low-level laser therapy in headand-neck cancer patients undergoing concurrent chemoradiotherapy: a phase III randomized study. Int J Radiat Oncol Biol Phys 2012;82(1):270–5. DOI: 10.1016/j.ijrobp.2010.10.012.

73. Oton-Leite A.F., Silva G.B., Morais M.O. et al. Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients. Lasers Surg Med 2015;47(4):296–305. DOI: 10.1002/lsm.22349.

74. Peterson D.E., Ohrn K., Bowen J. et al. Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer 2013;21(1):327–32. DOI: 10.1007/s00520-012-1562-0.

75. Gorgu S.Z., Ilknur A., Sercan O. et al. The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer. Iranian J Radiat Res 2013;11:111–6.

76. Sangthawan D., Phungrassami T., Sinkitjarurnchai W. A randomized doubleblind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients. J Med Assoc Thai 2013;96(1):69–76.

77. Moslemi D., Babaee N., Damavandi M. et al. Oral zinc sulphate and prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancers: a double blind, randomized controlled clinical trial. Int J Radiat Res 2014;12:235–41.

78. Yarom N., Hovan A., Bossi P. et al. Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines-part 1: vitamins, minerals, and nutritional supplements. Support Care Cancer 2019;27(10):3997–4010. DOI: 10.1007/s00520-019-04887-x.

79. Biswal B.M., Zakaria A., Ahmad N.M. Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer 2003;11(4):242–8. DOI: 10.1007/s00520-003-0443-y.

80. Jayachandran S., Balaji N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J Palliat Care 2012;18(3):190–5. DOI: 10.4103/0973-1075.105689.

81. Maiti P.K., Ray A., Mitra T.N. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J Indian Med Assoc 2012;110(7):453–6.

82. Motallebnejad M., Akram S., Moghadamnia A. et al. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract 2008;9(3):40–7.

83. Rashad U.M., Al-Gezawy S.M., El-Gezawy E., Azzaz A.N. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol 2009;123(2):223–8. DOI: 10.1017/S0022215108002478.

84. Samdariya S., Lewis S., Kauser H. et al. A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients. Indian J Palliat Care 2015;21(3):268–73. DOI: 10.4103/0973-1075.164892.

85. Yarom N., Hovan A., Bossi P. et al. Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines – part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents. Support Care Cancer 2020;28(5):2457–72. DOI: 10.1007/s00520-019-05256-4.

86. Chitapanarux I., Traisathit P., Chitapanarux T. et al. Arginine, glutamine, and fish oil supplementation in cancer patients treated with concurrent chemoradiotherapy: a randomized control study. Curr Probl Cancer 2020;44(1):121–32. DOI: 10.1016/j.currproblcancer.2019.05.005.

87. Piredda M., Facchinetti G., Biagioli V. et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: a pilot randomised controlled trial. Eur J Cancer Care (Engl) 2017;26(6). DOI: 10.1111/ecc.12757.

88. Marucci L., Farneti A., Di Ridolfi P. et al. Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer. Head Neck 2017;39(9):1761–9. DOI: 10.1002/hed.24832.

89. Matsuda C., Munemoto Y., Mishima H. et al. Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol 2015;76(1):97–103. DOI: 10.1007/s00280-015-2767-y.

90. Khurana H., Pandey R.K., Saksena A.K., Kumar A. An evaluation of vitamin E and pycnogenol in children suffering from oral mucositis during cancer chemotherapy. Oral Dis 2013;19(5):456–64. DOI: 10.1111/odi.12024.

91. Ahmed K.M. The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer. A randomized clinical trial. Saudi Dent J 2013;25(4):141–7. DOI: 10.1016/j.sdentj.2013.09.001.

92. Luo Y., Feng M., Fan Z. et al. Effect of kangfuxin solution on chemo/radiotherapy-induced mucositis in nasopharyngeal carcinoma patients: a multicenter, prospective randomized phase III clinical study. Evid Based Complement Alternat Med 2016;2016:8692343. DOI: 10.1155/2016/8692343.

93. Carulli G., Rocco M., Panichi A. et al. Treatment of oral mucositis in hematologic patients undergoing autologous or allogeneic transplantation of peripheral blood stem cells: a prospective, randomized study with a mouthwash containing Camelia Sinensis leaf extract. Hematol Rep 2013;5(1):21–5. DOI: 10.4081/hr.2013.e6.

94. Kong M., Hwang D.-S., Yoon S.W., Kim J. The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: a single-blind randomized preliminary study. Onco Targets Ther 2016; 9:4533–8. DOI: 10.2147/OTT.S108769.

95. Das D., Chandola H., Agarwal S. Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies. Ayu 2011;32(2):196–9. DOI: 10.4103/0974-8520.92579.

96. Babaee N., Moslemi D., Khalilpour M. et al. Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: A randomized controlled clinical study. Daru 2013;21(1):18. DOI: 10.1186/2008-2231-21-18.

97. Miranzadeh S., Adib-Hajbaghery M., Soleymanpoor L., Ehsani M. A new mouthwash for chemotherapy induced stomatitis. Nurs Midwifery Stud 2014;3(3):e20249. DOI: 10.17795/nmsjournal20249.

98. Elkerm Y., Tawashi R. Date palm pollen as a preventative intervention in radiationand chemotherapy-induced oral mucositis: a pilot study. Integr Cancer Ther 2014;13(6):468–72. DOI: 10.1177/1534735414547110.

99. Giacomelli I., Scartoni D., Fiammetta M. et al. Oral Lapacho-based medication: an easy, safe, and feasible support to prevent and/or reduce oral mucositis during radiotherapy for head and neck cancer. Nutr Cancer 2015;67(8):1249–53. DOI: 10.1080/01635581.2015.1082114.

100. Bertoglio J.C., Calderón S., Lesina B. et al. Effect of SAMITAL® in the treatment of chemotherapy-induced mucositis in adult oncohematological patients. Future Oncol 2013;9(11):1727–32. DOI: 10.2217/fon.13.164.

101. Limaye S.A., Haddad R.I., Cilli F. et al. Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy. Cancer 2013;119(24):4268–76. DOI: 10.1002/cncr.28365.

102. Sharma A., Rath G.K., Chaudhary S.P. et al. Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapyinduced mucositis in patients with head and neck cancer: a randomized doubleblind placebo-controlled study. Eur J Cancer 2012;48(6):875–81. DOI: 10.1016/j.ejca.2011.06.010.

103. Yen S.H., Wang L.-W., Lin Y.-H. et al. Phenylbutyrate mouthwash mitigates oral mucositis during radiotherapy or chemoradiotherapy in patients with head-andneck cancer. Int J Radiat Oncol Biol Phys 2012;82(4):1463–70. DOI: 10.1016/j.ijrobp.2011.04.029.

104. Baharvand M., Hamian M., Moosavizadeh M.A. et al. Phenytoin mouthwash to treat cancer therapy-induced oral mucositis: a pilot study. Indian J Cancer 2015;52(1):81–5. DOI: 10.4103/0019-509X.175597.

105. Karaca H., Bozkurt O., Ozaslan E. et al. Positive effects of oral β-glucan on mucositis and leukopenia in colorectal cancer patients receiving adjuvant FOLFOX-4 combination chemotherapy. Asian Pac J Cancer Prev 2014;15(8):3641–4. DOI: 10.7314/apjcp.2014.15.8.3641.

106. Bonfili P., Gravina G.L., Marampon F. et al. Oral platelet gel supernatant plus supportive medical treatment versus supportive medical treatment in the management of radiation-induced oral mucositis. Am J Clin Oncol 2017;40(4):336–41. DOI: 10.1097/COC.0000000000000177.

107. Atay M.H., Aslan N.A., Aktimur S., Buyukkaya P. et al. Safety and efficacy of ankaferd hemostat (ABS) in the chemotherapy-induced oral mucositis. UHOD Uluslararasi Hematoloji-Onkoloji Dergisi 2015;25(3):166–171. DOI: 10.4999/uhod.15811.


Для цитирования:


Ерёмина А.О., Задеренко И.А., Иванов С.Ю., Алиева С.Б., Дымников А.Б., Хромушина А.В., Пхешхова Б.Г. Оральные мукозиты у пациентов с онкологической патологией орофарингеальной области: обзор литературы. Опухоли головы и шеи. 2020;10(3):72-80. https://doi.org/10.17650/2222-1468-2020-10-3-72-80

For citation:


Eremina A.O., Zaderenko I.A., Ivanov S.Yu., Alieva S.B., Dymnikov A.B., Khromushina A.V., Pkheshkhova B.C. Oral mucositis in patients with oncological pathology of the oropharyngeal region: review. Head and Neck Tumors (HNT). 2020;10(3):72-80. (In Russ.) https://doi.org/10.17650/2222-1468-2020-10-3-72-80

Просмотров: 41


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2222-1468 (Print)
ISSN 2411-4634 (Online)