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PROGNOSTIC SIGNIFICANCE OF BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA. REVIEW
- Authors: Ignatova A.V.1, Mudunov A.M.2, Narimanov M.N.2
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Affiliations:
- Russian Medical Academy of Post-Graduate Education., Moscow
- Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow
- Issue: Vol 4, No 4 (2014)
- Pages: 28-33
- Section: LITERATURE REVIEW
- Published: 15.04.2014
- URL: https://ogsh.abvpress.ru/jour/article/view/111
- DOI: https://doi.org/10.17650/2222-1468-2014-0-4-28-33
- ID: 111
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Abstract
Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of molecules-biomarkers that can be used for prediction of behaviour of this disease to achieve the above objective.
We identified and classified 24 molecular biomarkers into five groups based on their biological functions: 1) cell cycle acceleration and proliferation; 2) hypoxia-inducible factors; 3) tumour suppression and apoptosis; 4) angiogenesis; 5) cell adhesion and matrix degradation. We considered articles published in PubMed-indexed journals over the past 8 years and conducted a literature review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome.
About the authors
A. V. Ignatova
Russian Medical Academy of Post-Graduate Education., Moscow
Author for correspondence.
Email: annasurge@gmail.com
Department of Oncology Russian Federation
A. M. Mudunov
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow
Email: annasurge@gmail.com
Russian Federation
M. N. Narimanov
Research Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow
Email: annasurge@gmail.com
Russian Federation
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