“Watch and wait” approach in the treatment of advanced radioiodine refractory differentiated thyroid cancer: a study of barriers and drivers of use

E. V. Borodavina; Бородавина Е. В.; A. Yu. Shurinov; Шуринов А. Ю.; S. I. Kutukova; Кутукова С. И.; E. N. Nedozorova; Недозорова Е. Н.; A. V. Malanchuk; Маланчук А. В.; Yu. V. Semenchenko; Семенченко Ю. В.; S. M. Povarkov; Поварков С. М.; K. V. Narovenkova; Наровенкова К. В.; A. V. Khodkevich; Ходкевич А. В.; Yu. V. Komoza; Комоза Ю. В.; K. A. Kofanova; Кофанова К. А.; S. P. Dmitriev; Дмитриев С. П.; E. B. Vasilyeva; Васильева Е. Б.; S. A. Shikhamirova; Шихамирова С. А.; M. N. Gorshenina; Горшенина М. Н.; L. N. Volodina; Володина Л. Н.; O. A. Snezhko; Снежко О. А.; O. A. Stativko; Стативко О. А.; D. V. Xenodokhov; Ксенодохов Д. В.; Yu. G. Dzhemageldieva; Джемагельдиева Ю. Г.; A. I. Khryapa; Хряпа А. И.; D. M. Ulimaeva; Улимаева Д. М.; E. M. Dagba; Дагба Е. М.; M. V. Volkonsky; Волконский М. В.; V. M. Filippova; Филиппова В. М.; M. O. Skorina; Скорина М. О.; O. V. Romanchuk; Романчук О. В.; I. I. Andrienko; Андриенко И. И.; M. V. Shorin; Шорин М. В.; A. A. Ishchenko; Ищенко А. А.; R. A. Dumbrava; Думбрава Р. А.; M. B. Bolieva; Болиева M. Б.; F. V. Tsarakhova; Царахова Ф. В.; Z. A. Gojieva; Годжиева З. А.; S. S. Dzhamirzaeva; Джамирзаева С. С.; P. Z. Aidaeva; Айдаева П. З.; M. O. Maximov; Максимов М. О.; I. S. Usoltseva; Усольцева И. С.; A. O. Milyukova; Милюкова А. О.; O. V. Toporkova; Топоркова О. В.; V. D. Sychev; Сычёв В. Д.; S. A. Rudakov; Рудаков С. А.; S. T. Sagdieva; Сагдиева С. Т.; M. A. Klochikhin; Клочихин М. А.; V. V. Molokova; Молокова В. В.; R. A. Skotnikov; Скотников Р. А.; E. N. Yeremina; Еремина Е. Н.; Yu. A. Panaseikin; Панасейкин Ю. А.; Ya. A. Tyugina; Тюгина Я. А.; Yu. I. Murzina; Мурзина Ю. И.; S. O. Podvyaznikov; Подвязников С. О.

doi:10.17650/2222-1468-2023-13-4-73-82

“Watch and wait” approach in the treatment of advanced radioiodine refractory differentiated thyroid cancer: a study of barriers and drivers of use

Authors: Borodavina E.V.¹, Shurinov A.Y.¹, Kutukova S.I.², Nedozorova E.N.³, Malanchuk A.V.⁴, Semenchenko Y.V.⁴, Povarkov S.M.⁴, Narovenkova K.V.⁵, Khodkevich A.V.⁵, Komoza Y.V.⁵, Kofanova K.A.⁶, Dmitriev S.P.⁶, Vasilyeva E.B.⁷, Shikhamirova S.A.⁸, Gorshenina M.N.⁹, Volodina L.N.¹⁰, Snezhko O.A.¹¹, Stativko O.A.¹², Xenodokhov D.V.¹³, Dzhemageldieva Y.G.¹³, Khryapa A.I.¹⁴, Ulimaeva D.M.¹⁴, Dagba E.M.¹⁴, Volkonsky M.V.¹⁵, Filippova V.M.¹⁵, Skorina M.O.¹⁵, Romanchuk O.V.¹⁶, Andrienko I.I.¹⁷, Shorin M.V.¹⁸, Ishchenko A.A.¹⁹, Dumbrava R.A.²⁰, Bolieva M.B.²¹, Tsarakhova F.V.²¹, Gojieva Z.A.²¹, Dzhamirzaeva S.S.²², Aidaeva P.Z.²², Maximov M.O.²³, Usoltseva I.S.²⁴, Milyukova A.O.²⁴, Toporkova O.V.²⁵, Sychev V.D.²⁵, Rudakov S.A.²⁵, Sagdieva S.T.²⁶, Klochikhin M.A.²⁶, Molokova V.V.²⁷, Skotnikov R.A.²⁸, Yeremina E.N.²⁹, Panaseikin Y.A.¹, Tyugina Y.A.³⁰, Murzina Y.I.¹¹, Podvyaznikov S.O.³¹^,32
Affiliations:
1. A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Center of Radiology, Ministry of Health of the Russia
2. Academician I.P. Pavlov First St. Petersburg State Medical University
3. Republican Clinical Oncological Dispensar, Ministry of Health of the Chuvash Republic
4. Voronezh Regional Clinical Oncological Dispensary
5. Bryansk Regional Oncological Dispensary
6. Scientific Research Institute of Clinical Oncology Nizhny Novgorod Regional Clinical Oncological Dispensary
7. Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
8. Republican Cancer Center
9. Republican Clinical Oncological Dispensary
10. Regional Clinical Oncological Dispensary
11. Oncological Dispensary
12. City Cancer Hospital No. 1, Moscow Healthcare Department
13. Clinical Oncological Dispensary No. 1, Ministry of Health of the Krasnodar Territory
14. Leningrad Regional Clinical Hospital
15. Moscow Cancer Hospital No. 62, Moscow Healthcare Department
16. Moscow Multidisciplinary Clinical Center “Kommunarka”, Moscow Healthcare Department
17. Klinsk Hospital
18. Naro-Fominsk Hospital
19. Regional Oncological Dispensary
20. Primorsk Regional Oncological Dispensary
21. Republican Oncological Dispensary, Ministry of Health of the Republic of North Ossetia–Alania
22. Republican Oncological Dispensary
23. Republican Oncological Dispensary, Ministry of Health of the Republic of Khakassia
24. Sakhalin Regional Clinical Oncological Dispensary
25. Tambov Regional Oncological Clinical Dispensary
26. Regional Clinical Oncological Hospital
27. Zabaikalsky Regional Oncological Dispensary
28. Tula Regional Clinical Oncological Dispensary
29. Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky
30. Ivanovo Regional Oncological Dispensary
31. N.N. Blokhin National Medical Russian Research Center of Oncology, Ministry of Health of Russia
32. Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Issue: Vol 13, No 4 (2023)
Pages: 73-82
Section: DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS
Published: 30.12.2023
URL: https://ogsh.abvpress.ru/jour/article/view/939
DOI: https://doi.org/10.17650/2222-1468-2023-13-4-73-82
ID: 939

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Abstract

Introduction. The multikinase inhibitors have demonstrated high clinical efficacy in treatment of the radioiodine refractory differentiated thyroid cancer. At the same time, the inclusion criteria in the studies has reflected a minimum set of characteristics important for beginning of use of these drugs and an approach that takes into account the tumor progression rate (the volume doubling time) in the absence of clinical manifestations of the disease that have made it possible to individualize the start of therapy.

Aim. To describe and evaluate the barriers and drivers of use the “watch and wait” approach by Russian oncologists in treatment of the radioiodine refractory thyroid cancer.

Materials and methods. We conducted 35 structured interviews with oncologists observing patients after radioiodine therapy in order to evaluate the “watch and wait” approach. unfortunately, data on use and prevalence of this approach in Russia are limited. The present study involved the use of deductive content analysis as well as analysis of implementation model of clinical guidelines and included investigation of issue of implementation of the “watch and wait” approach to current practice of therapy for radioiodine refractory differentiated thyroid cancer. One of the main tasks was to determine the influence of external factors on the treatment of this category of patients.

Conclusion. Barriers and drivers of using “watch and wait” approach in the treatment of differentiated radioiodine refractory thyroid cancer are identified at several levels. for wide use of this approach, it is necessary to involve oncologists taking into account their attitude regarding changes in routine practices, patient expectations and to obtain additional data regarding its long-term effectiveness.

Keywords

differentiated thyroid cancer, radioiodrefract cancer, “watch and wait” approach

About the authors

E. V. Borodavina

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Center of Radiology, Ministry of Health of the Russia

Author for correspondence.
Email: smysmymrik2007@yandex.ru
ORCID iD: 0000-0002-3306-5906

Ekaterina Vladimirovna Borodavina

249036; 4 Koroleva St.; Obninsk

Russian Federation

A. Yu. Shurinov

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Center of Radiology, Ministry of Health of the Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-4934-2012

249036; 4 Koroleva St.; Obninsk

Russian Federation

S. I. Kutukova

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: fake@neicon.ru
ORCID iD: 0000-0003-2221-4088

197022; 6–8 L’va Tolstogo St.; Saint Petersburg

Russian Federation

E. N. Nedozorova

Republican Clinical Oncological Dispensar, Ministry of Health of the Chuvash Republic

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“Watch and wait” approach in the treatment of advanced radioiodine refractory differentiated thyroid cancer: a study of barriers and drivers of use

Full Text

Abstract

Keywords

About the authors

References

Supplementary files