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Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck
- Authors: Bolotina L.V.1, Deshkina T.I.1, Kornietskaya A.L.1, Kravtsov S.A.2, Ustinova T.V.1, Paychadze A.A.1, Kaprin A.D.1, Fedenko А.А.1
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Affiliations:
- P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
- City Clinical Hospital No. 1, Moscow Healthcare Department
- Issue: Vol 10, No 2 (2020)
- Pages: 10-21
- Section: DIAGNOSIS AND TREATMENT OF HEAD AND NECK TUMORS
- Published: 23.07.2020
- URL: https://ogsh.abvpress.ru/jour/article/view/522
- DOI: https://doi.org/10.17650/2222-1468-2020-10-2-10-21
- ID: 522
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Abstract
The results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction chemotherapy can be used, including platinum drugs, preferably in combination with cetuximab. Next immuno-oncological drugs should be prescribed. In the future, in the 1st line of therapy, it is possible to replace cetuximab with pembrolizumab or monotherapy with pembrolizumab, which allows to increase the effectiveness of treatment and reduce its toxicity. The article presents 3 clinical observations that demonstrate the possibility of integration the results of clinical research in practice.
About the authors
L. V. Bolotina
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Author for correspondence.
Email: lbolotina@yandex.ru
ORCID iD: 0000-0003-4879-2687
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
T. I. Deshkina
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-3371-7548
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
A. L. Kornietskaya
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0003-0092-0459
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
S. A. Kravtsov
City Clinical Hospital No. 1, Moscow Healthcare Department
Email: fake@neicon.ru
ORCID iD: 0000-0002-0681-8976
17/1 Baumanskaya St., Moscow 105005 Russian Federation
T. V. Ustinova
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-2061-0522
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
A. A. Paychadze
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0001-7912-8055
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
A. D. Kaprin
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0001-8784-8415
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
А. А. Fedenko
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
3 2 nd Botkinsky Dr., Moscow 125284 Russian Federation
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