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Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer
- Authors: Kaprin A.D.1, Ivanov S.A.1, Sevryukov F.E.1, Pimonova I.S.1, Isaev P.A.1, Severskaya N.V.1, Ilyin A.A.1, Polkin V.V.1, Siomin D.Y.1, Vasilkov S.V.1, Derbugov D.N.1, Panaseikin Y.A.1, Medvedev V.S.1
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Affiliations:
- National Medical Research Radiological Center, Ministry of Health of Russia.
- Issue: Vol 8, No 3 (2018)
- Pages: 72-76
- Section: ORIGINAL REPORT
- Published: 07.11.2018
- URL: https://ogsh.abvpress.ru/jour/article/view/363
- DOI: https://doi.org/10.17650/2222-1468-2018-8-3-72-76
- ID: 363
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Abstract
The study objective is to evaluate modern-era radiotherapy (external beam radiotherapy, EBRT) and target therapy (TT) outcomes for advanced medullary thyroid cancer (MTC).
Materials and methods. Seventy eight consecutive patients with stage IV MTC were evaluated. All of them with relapsing locally advanced or metastatic MTC, 16 had clinically relevant mediastinal involvement, and 59 had distant metastasis; 26 patients received conformal EBRT or intensity-modulated radiotherapy in monomode, 16 patients – conformal EBRT with simultaneous TT with vandenanib, 36 patients – TT in monomode. Median EBRT dose was 60 Gy.
Results. Kaplan–Meier estimates of the median overall survival rate was 14 months for radiotherapy in monomode, 48 months – for conformal EBRT + simultaneous TT with vandenanib, 50 months – for TT in monomode. EBRT and TT allows for significantly shorter periods (median 3.8 weeks), to relieve the symptoms of compression-mediated organs and structures of the neck and mediastinum than in the TT (median 10.2 weeks) (p <0.001).
Conclusion. EBRT and TT provided durable locoregional disease control with limited morbidity.
About the authors
A. D. Kaprin
National Medical Research Radiological Center, Ministry of Health of Russia.
Author for correspondence.
Email: fake@neicon.ru
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
S. A. Ivanov
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0001-7689-6032
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
F. E. Sevryukov
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0002-9756-6275
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
I. S. Pimonova
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
P. A. Isaev
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: isaev@mrrc.obninsk.ru
ORCID iD: 0000-0001-9831-4814
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
N. V. Severskaya
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0002-9426-8459
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
A. A. Ilyin
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0002-6581-633X
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
V. V. Polkin
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0003-0857-321X
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
D. Yu. Siomin
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0003-0442-6933
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
S. V. Vasilkov
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
ORCID iD: 0000-0002-4423-5640
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
D. N. Derbugov
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
Yu. A. Panaseikin
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
V. S. Medvedev
National Medical Research Radiological Center, Ministry of Health of Russia.
Email: fake@neicon.ru
3 2nd Botkinsky Proezd, Moscow 125284. Russian Federation
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