The effect of oral cavity condition on expression of saliva biomarkers in patients with oral mucosa pathology
https://doi.org/10.17650/2222-1468-2024-14-3-83-91
Abstract
Introduction. Despite visual accessibility of the elements of tumor lesions in the oral mucosa, patients with this pathology rarely seek medical help. Regeneration of the mucosa is a long process taking varying time depending on the location of the lesions. Asymptomatic tumor process leads to its diagnosis at late stages.
Aim. To develop clinical and proteomic approach to diagnosis of malignancies of the oral mucosa at the stage of out-patient dentist appointment.
Clinical observations. Examples of extended clinical, dental and immunoenzymatic monitoring in patients with elements of tumor lesions of the oral mucosa with long-term course are presented.
Conclusion. The use of extended clinical, dental and immunoenzymatic analysis of oral fluid in patients with elements of tumor lesions of the oral mucosa allows to diagnose this pathology early.
About the Authors
E. V. Kochurova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119048
O. I. Panferova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119048
E. O. Kudasova
Synergy University
Russian Federation
Russian Federation
80 Leningradsky Prospekt, 125080 Moscow
E. V. Izhnina
Kuban State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
4 Mitrofana Sedina St., Krasnodar 350063
O. S. Guyter
I.P. Pavlov Ryazan State Medical University, Ministry of Health of the Russia
Russian Federation
Russian Federation
9 Vysokovoltnaya St., Ryazan 390026
D. V. Ermolin
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 2, 8 Trubetskaya St., Moscow 119048
References
1. Fuoad S.A.A., Mohammad D.N., Hamied M.A., Garib B.T. Orofacial malignancy in north of Iraq: a retrospective study of biopsied cases. BMC Oral Health 2021;21(1):147. DOI: 10.1186/s12903-021-01521-3
2. Reshetov I.V., Nikolenko V.N., Kochurova E.V. et al. Implementation of the principles of oncological alertness in the treatment of patients with pathological processes of the oral mucosa. Head and Neck. Golova i sheya = Head and Neck 2024;12(2):90–8. (In Russ.). DOI: 10.25792/HN.2024.12.2.90-98
3. Olsen A., Tjønneland A.M. Alcohol consumption and risk of cancer. Ugeskr Laeger 2021;183(14):V12200929.
4. Sikorsky D.V., Podvyaznikov S.O., Kanishcheva N.V. et. al. Total glossectomy in multimodal treatment of oropharyngeal cancer: immediate results. Opukholi golovy i shei = Head and Neck Tumors 2020;10(1):38–46. (In Russ.). DOI: 10.17650/2222-1468-2020-10-1-38-46
5. Shinn J.R., Davis S.J., Lang-Kuhs K.A. et al. Oropharyngeal squamous cell carcinoma with discordant p16 and HPV MRNA results: incidence and characterization in a large, contemporary united states cohort. Am J Surg Pathol 2021;4(7):951961. DOI: 10.1097/PAS.0000000000001685
6. Kochurova E.V., Nikolenko V.N., Kudasova E.O. et al. Low dental status as an indicator of malignancy of the oral mucosa. Opukholi golovy i shei = Head and Neck Tumors 2023;13(4):83–91. (In Russ.). DOI: 10.17650/2222-1468-2023-13-4-83-91
7. Brouwer P., Bikker F.J., Brand H.S., Kaman W.E. Is TIMP-1 a biomarker for periodontal disease? A systematic review and metaanalysis. J Periodontal Res 2022;57(2):235–45. DOI: 10.1111/jre.12957
8. Chattopadhyay I., Verma M., Panda M. Role of oral microbiome signatures in diagnosis and prognosis of oral cancer. Technol Cancer Res Treat 2019;18:1533033819867354. DOI: 10.1177/1533033819867354
9. Kochurova E.V., Kudasova E.O., Nikolenko V.N., Panferovа O.I. The role of oral fluid biomarkers in the diagnosis of cancer of the oral mucosa. Voprosy onkologii = Questions of Oncology 2022;5:565–70. (In Russ.).
10. Jäsberg H., Tervahartiala T., Sorsa T. et al. Probiotic intervention influences the salivary levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinases (TIMP)-1 in healthy adults. Arch Oral Biol 2018;85:58–63. DOI: 10.1016/j.archoralbio.2017
11. Afacan B., Çınarcık S., Gürkan A. et al. Full-mouth disinfection effects on gingival fluid calprotectin, osteocalcin, and N-telopeptide of type I collagen in severe periodontitis. J Clin Periodontol 2020;91(5):638–50. DOI: 10.1002/JPER.19-0445
12. Wetzels J.W.G.H., Meijer G.J., Koole R. et al. Costs and clinical outcomes of implant placement during ablative surgery and postponed implant placement in curative oral oncology: a five-year retrospective cohort study. Clin Oral Implants Res 2017;28(11):1433–42. DOI: 10.1111/clr.13008
13. Michaud D.S., Fu Z., Shi J., Chung M. Periodontal disease, tooth loss, and cancer risk. Epidemiol Rev 2017;39(1):49–58. DOI: 10.1093/epirev/mxx006
14. Malignant neoplasms of the lip. Clinical guidelines. (In Russ.). Available at: https://legalacts.ru/doc/klinicheskie-rekomendatsiizlokachestvennye-novoobrazovanija-guby-utv-minzdravom-rossii/.
15. Malignant neoplasms of the oral cavity. Clinical guidelines. 2020. (In Russ.). Available at: https://legalacts.ru/doc/klinicheskierekomendatsii-zlokachestvennye-novoobrazovanija-polosti-rta-utvminzdravom-rossii_1/.
16. Malignant neoplasms of the oral cavity. Clinical recommendations. Coding according to the International Statistical Classification of Diseases and Related Health Problems: C02.0, C02.1, C02.2, C02.3, C02.8, C02.9, C03, C04, C05.0, C06. 2020. (In Russ.). Available at: https://sudact.ru/law/klinicheskie-rekomendatsiizlokachestvennye-novoobrazovaniia-polosti-rta-utv/ klinicheskie-rekomendatsii/.
Review
For citations:
Kochurova E.V., Panferova O.I., Kudasova E.O., Izhnina E.V., Guyter O.S., Ermolin D.V. The effect of oral cavity condition on expression of saliva biomarkers in patients with oral mucosa pathology. Head and Neck Tumors (HNT). 2024;14(3):83-91. (In Russ.) https://doi.org/10.17650/2222-1468-2024-14-3-83-91
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