Nutritional support in patients with squamous cell carcinoma of the oropharyngeal area
https://doi.org/10.17650/2222-1468-2016-6-1-39-42
Abstract
Up to half of all patients with squamous cell carcinoma of the oropharyngeal area start their treatment when they have malnutrition that results from the primary disease. The main causes of weight loss in oropharyngeal tumors are pain syndrome and dysphagia of various etiologies, which lead to malnutrition and dehydration, as well as intoxication caused by tumor lysis and contamination. This results in impaired metabolic processes, worsening the general condition of patients. During further antitumor therapy, the manifestations of malnutrition are only aggravated, which is due to the high toxicity of chemoradiation therapy and the traumaticity of surgical interventions.
About the Authors
A. M. Mudunov
Head and Neck Tumor Department, Surgery Division for Tumors of the Upper Respiratory and Digestive Tracts, N.N. Blokhin Russian Cancer Research Center at the Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Russian Federation
Russian Federation
D. B. Udintsov
Head and Neck Tumor Department, Surgery Division for Tumors of the Upper Respiratory and Digestive Tracts, N.N. Blokhin Russian Cancer Research Center at the Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Russian Federation
Russian Federation
References
1. Langius J.A., Doornaert P., Spreeuwenberg M.D. et al. Radiotherapy on the neck nodes predicts severe weight loss in patients with early stage laryngeal cancer. Radiother Oncol 2010;97(1):80–5.
2. Matthews T.W., Lampe H.B., Dragosz K. Nutritional status in head and neck cancer patients. J Otolaryngol 1995;24(2):87–91.
3. Unsal D., Mentes B., Akmansu M. et al. Evaluation of nutritional status in cancer patients receiving radiotherapy: a prospective study. Am J Clin Oncol 2006;29(2):183–8.
4. Couch M.E., Dittus K.,. Toth M.J. et al. Cancer cachexia update in head and neck cancer: Definitions and diagnostic features. Head Neck 2015;37(4):594–604.
5. Vermorken J.B., Remenar E., van Herpen C. at al. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 2007;357(17):1695–704.
6. Wendt T.G., Grabenbauer G.G., Rodel C.M. et al. Simultaneous radiochemotherapy alone in advanced head and neck cancer: a randomized multicenter study. J Clin Oncol 1998;16(4):1318–24.
7. Луфт В.М., Луфт А.В. Нутриционная поддержка онкологических больных: возможности и противоречия. Вестник интенсивной терапии 2008;(2):43–50. [Luft V.М., Luft А.V. Nutritional support of oncologic patients: possibilities and contradictions. Vestnik intensivnoy terapii = Herald of the Intensive Therapy 2008;(2):43– 50. (In Russ.)].
8. Практические рекомендации по нутритивной поддержке при химиотерапии и/или лучевой терапии. Доступно по ссылке: http://www.rosoncoweb.ru/ standarts/RUSSCO/2-09.pdf. [Practical recommendations on the nutritive support at chemical and /or radial therapy. Available at: http://www.rosoncoweb.ru/standarts/ RUSSCO/2-09.pdf. (In Russ.)].
9. Mekhail T.M., Adelstein D.J., Rybicki L.A. et al. Nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube? Cancer 2001;91(9):1785–90.
10. Corry J., Poon W., McPhee N. et al. Prospective study of percutaneous endoscopic gastrostomy tubes versus nasogastric tubes for enteral feeding in patients with head and neck cancer undergoing (chemo)radiation. Head Neck 2009;31(7):867–76.
11. Langius J.A., Zandbergen M.C., Eerenstein S.E. et al. Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo) radiotherapy: a systematic review. Clin Nutr 2013;32(5):671–8.
12. Bossola M. Nutritional interventions in head and neck cancer patients undergoing chemoradiotherapy: a narrative review. Nutrients 2015;7(1):265–76.
13. Langius J.A., Bakker S., Rietveld D. H. et al. Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy. Br J Cancer 2013;109(5):1093–9.
14. van Bokhorst-de van der Schueren M.A.,van Leeuwen P.A., Sauerwein H.P. et al. Assessment of malnutrition parameters in head and neck cancer and their relation to postoperative complications. Head Neck 1997;19(5):419–25.
15. de Luis D.A., Aller R., Izaola O. et al. Postsurgery enteral nutrition in head and neck cancer patients. Eur J Clin Nutr 2002;56(11):1126–9.
16. Доброхотова В.З. Анализ осложнений реконструктивных операций при злокачественных опухолях полости рта. Дис. ... канд. мед. наук. М., 2006. [Dobrohotovа V.Z. Аnalysis of complications of reconstructive operations at malignant tumors of the mouth cavity. Thesis ... of doctor of medicine. Мoscow, 2006 (In Russ.)].
Review
For citations:
Mudunov A.M., Udintsov D.B. Nutritional support in patients with squamous cell carcinoma of the oropharyngeal area. Head and Neck Tumors (HNT). 2016;6(1):39-42. (In Russ.) https://doi.org/10.17650/2222-1468-2016-6-1-39-42
Views:
696
Email this article 