Lung cancer brain metastases – the role of neurosurgery
https://doi.org/10.17650/2222-1468-2016-6-2-42-49
Abstract
Lung cancer is mostly common occurring oncological disease in the developed countries. Currently lung cancers are subdivided into nonsmall-cell (adenocarcinoma, large-cell, squamous cell) and small-cell. The difference in the clinical and morphological picture leads to the necessity of choosing therapeutic approaches to patients of various groups.
Lung cancer should be referred to encephalotropic diseases since metastatic lesion of the central nervous system is sufficiently common complication. Successes of complex treatment of primary tumor result in increase of total longlivety currently ther is ageing of patients suffering lung cancer. These factors increase the risk of metastatic lesions of the brain.
Interest to the problem of neurosurgical treatment of patients suffering lung cancer is determined by frequency of lesion, varicosity of morphological variants of the disease, requiring various algorithms of treatment and diagnosis.
The main role of neurosurgical intervention in cerebral metastases of lung cancer consist in creation of the paled of carrying out combined therapy. Ideally, a neurosurgical operation should be carried out with clearcut observance of oncological principles of ablasty.
Adequate comprehensive approach to treatment or patients with cerebral metastases of various forms of lung cancer with the developed of optimal tactics of and stages of treatment would make it possible to increase duration and quality of life of patients.
About the Authors
V. A. Aleshin
N.N. Blokhin Russian Cancer Research Center at the Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
V. B. Karakhan
N.N. Blokhin Russian Cancer Research Center at the Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
A. Kh. Bekyashev
N.N. Blokhin Russian Cancer Research Center at the Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
D. M. Belov
N.N. Blokhin Russian Cancer Research Center at the Ministry of Health of Russia
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
Russian Federation
23 Kashirskoe Shosse, Moscow, 115478
References
1. Карахан В.Б., Алешин В.А., Белов Д.М. и др. Новые хирургические технологии удаления метастазов рака в головном мозге в зависимости от топографии, количества и макроструктуры опухолевых узлов. В сб.: Современные проблемы нейроонкологии: сборник статей научной конференции, посвященной созданию нейрохирургического (онкологического) отделения. М.: Издательская группа РОНЦ, 2007. С. 6–12. [Karakhan V.B., Aleshin V.A., Belov D.M. et al. New surgical technologies of removal of cancer metastases in the brain depending on the topography, amount and microstructure of tumor nodules. In vol.: Modern neuro-oncology problems: collection of articles of the scientific conference for creation of a neurosurgical (oncological) department. Moscow: N.N. Blokhin RCRC Publishing Group, 2007. Pp. 6–12. (In Russ.)].
2. Ротин Д.Л., Паклина О.В., Кобяков Г.Л. и др. Клинико-морфологические факторы прогноза при метастазах рака легкого в головной мозг. Вопросы нейрохирургии им. Н.Н. Бурденко 2013;77(1):24–9. [Rotin D.L., Paklina O.V., Kobyakov G.L. et al. Clinical and morphological prognosis factors in brain metastases of the lung cancer. Voprosy khirurgii im. N.N. Burdenko = N.N. Burdenko Center, Neurosurgery Issues 2013;77(1):24–9. (In Russ.)].
3. УлитинА.Ю., ОлюшинВ.Е., СафаровБ.И. Метастатические опухоли головного мозга. СПб., 2010. 384 с. [Ulitin A.Yu., Olyushin V.E., Safarov B.I. Metastatic brain tumors. Saint Petersburg, 2010. 384 p. (In Russ.)].
4. Andrews R.J., Gkick D.S., Konchingeri R.H. Surgical resection of brain metastases from lung cancer. Acta Neurochir (Wien) 1996;138(4):382–9.
5. Gaspar L., Scott C., Rotman M. et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 1997;37(4):745–51.
6. Jemal A., Bray F., Center M.M. et al. Global cancer statistics. CA Cancer J Clin 2011;61(2):69–90.
7. Kalkanis S.N, Kondziolka D., Gaspar L.E. et al. The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010;96(1): 33–43.
8. Landis S., Murray T., Bolden S., Wingo P.A. Cancer statistics, 1999. CA Cancer J Clin 1999;49(1):8–31.
9. Monninhoff C., Maderwald S., Theysohn J.M. et al. Imaging of brain metastases of bronchial carcinomas with 7 T MRI – initial results. Rofo 2010;182(9): 764–72.
10. Takeda T., Saitoh M., Takeda S. Solitary cystic brain metastasis of small-cell lung carcinoma controlled by a stereotactically inserted Ommaya reservoir. Am J Med Sci 2009;337(3):215–7.
Review
For citations:
Aleshin V.A., Karakhan V.B., Bekyashev A.Kh., Belov D.M. Lung cancer brain metastases – the role of neurosurgery. Head and Neck Tumors (HNT). 2016;6(2):42-49. (In Russ.) https://doi.org/10.17650/2222-1468-2016-6-2-42-49
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