PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA
https://doi.org/10.17650/2222-1468-2012-0-1-23-27
Abstract
The Medical Radiology Research Center Clinic performed photodynamic therapy (PDT) in 57 patients with cancer of the oral mucosa in the independent fashion. Pretreatment recurrent tumors were diagnosed in half (50.9 %) of the patients. Spectroscopy showed the therapeutic accumulation of the drug, which was 1.8–3 times greater than that in the skin and intact mucosa in the presence of a malignant neoplasm. Complete and partial tumor regression was achieved in 50 (87.7 %) and 4 (7 %) patients, respectively; stabilization was seen in 3 (5.3 %) patients. Three-year overall survival was 86.7 ± 5.2 % and three-year relapse-free survival was 70.5 ± 7.1 %. PDT has an organ-saving directionality, without causing functional and cosmetic impairments, thus showing its rather high effectiveness.
About the Authors
V. V. Polkin
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
M. A. Kaplan
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
V. S. Medvedev
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
D. Yu. Semin
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
V. N. Kapinus
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
I. S. Spichenkova
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
P. A. Isayev
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
D. N. Derbugov
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
A. M. Shubina
Medical Radiology Research Center, Ministry of Health and Social Development of Russia, Obninsk
Russian Federation
Russian Federation
References
1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45(4–5):309–16.
2. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2009 году (заболеваемость и смертность). М.: ФГУ МНИОИ им. П.А. Герцена МЗ и СР РФ, 2011. 260 с.
3. Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2007 г. Вестник РОНЦ им. Н.Н. Блохина РАМН 2009;20(3) (прил. 1):1–158.
4. Голдобенко Г.В., Канаев С.В. Современные проблемы радиационной онкологии. Вопр онкол 1997;43(5):481–7.
5. Горбунова В.А., Бредер В.В. Качество жизни онкологических больных. Материалы IV Росс. онкол. конф. М., 2000. С. 125–7.
6. Ионова Т.Н., Новик А.А., Сухонос Ю.А. Понятие качества жизни больных онкологического профиля. Онкология 2000; 2(1–2):25–7.
7. Цыб А.Ф., Каплан М.А., Романко Ю.С., Попучиев В.В. Клини ческие аспекты фото динамической терапии. Калуга: Издательство научной литературы Н.Ф. Бочкаревой, 2009. 204 с.
8. Вакуловская Е.Г., Стратонников А.А., Таболиновская Т.Д., Кондратьева Т.Т. Фотодинамическая терапия у больных раком слизистой оболочки полости рта, ротоглотки и нижней губы. Сибирск онкол журн 2005;2(14):13–7.
Review
For citations:
Polkin V.V., Kaplan M.A., Medvedev V.S., Semin D.Yu., Kapinus V.N., Spichenkova I.S., Isayev P.A., Derbugov D.N., Shubina A.M. PLACE OF PHOTODYNAMIC THERAPY IN ORGAN-SPARING TREATMENT PROGRAMS FOR SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA. Head and Neck Tumors (HNT). 2012;(1):23-27. (In Russ.) https://doi.org/10.17650/2222-1468-2012-0-1-23-27
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