Atypical teratoid rhabdoid tumor with intratumoral advancement: significance of active surgical approach in long-term disease (109 months) with metastatic cascade
https://doi.org/10.17650/2222-1468-2022-12-3-127-135
Abstract
The article presents a clinical case of atypical teratoid rhabdoid tumor with one of the longest catamnesis described in literature (109 months) and high quality of life. first, a giant tumor of the frontal lobe with advancement into a lateral ventricle was found in a female patient and totally removed. It was histologically diagnosed as primitive neuroectodermal tumor. Combination treatment consisting of radiotherapy, high-dose polychemotherapy and cellular immunotherapy including intrathecal therapy led to 4-year recurrence-free period. Recurrence of the tumor was resected. The period of the 2nd remission was 34 months. Subsequently, multistage metastasis of the tumor through cerebrospinal fluid tracts of the brain and spinal cord was observed. Twice microsurgical treatment with removal of symptomatic metastases in ventricles Iv and III was performed. In repeat morphological examinations, the tumor was verified as atypical teratoid rhabdoid tumor. The presented clinical case shows the role of active surgical tactics in effective long-term combination treatment of this severe pathology.
About the Authors
V. B. Karakhan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
E. V. Prozorenko
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
Bld. 2, 8 Trubetskaya St., Moscow 119991
G. L. Mentkevich
Tver’ State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
4 Sovetskaya St., Tver’ 170100
I. S. Dolgopolov
Tver’ State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
4 Sovetskaya St., Tver’ 170100
N. V. Sevyan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
Bld. 2, 8 Trubetskaya St., Moscow 119991
D. M. Belov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115522
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Review
For citations:
Karakhan V.B., Prozorenko E.V., Mentkevich G.L., Dolgopolov I.S., Sevyan N.V., Belov D.M. Atypical teratoid rhabdoid tumor with intratumoral advancement: significance of active surgical approach in long-term disease (109 months) with metastatic cascade. Head and Neck Tumors (HNT). 2022;12(3):127-135. (In Russ.) https://doi.org/10.17650/2222-1468-2022-12-3-127-135
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