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Clinical case of surgical treatment of advanced basal cell carcinoma of the skin on the face

https://doi.org/10.17650/2222-1468-2022-12-3-141-148

Abstract

Introduction. Basal cell carcinoma is the most common type of non-melanocytic malignant tumors of the skin. The main treatment methods for this pathology are local methods such as surgery and radiation. In rare cases, basal cell carcinoma can become locally advanced and / or metastatic.

Aim. To demonstrate the possibility of reconstructive surgery for large defects after removal of locally advanced tumors of the face and describe a rare case of basal cell carcinoma metastasis into the regional lymph nodes.

Clinical case. The article presents a clinical case of treatment of basal cell skin cancer with metastases into the regional lymph nodes. According to the patient, tumor on the skin of the left cheekbone area first appeared in 2007. The patient did not seek medical help. In 2017, the tumor was resected at the local medical facility. In 2018, the patient noted repeat tumor growth. In November of 2021, when the patient first consulted at the Republican Clinical Oncological Dispensary of the ministry of Health of the Bashkortostan Republic, the tumor was 7 × 5 cm. Invasion depth was up to 1.5 cm, infiltration into the temporal and mastication muscles and destruction of the zygomatic bone were observed. On 18.11.2021 at Republican Clinical Oncological Dispensary of the ministry of Health of the Bashkortostan Republic, wide resection of the skin tumor with resection of the zygomatic arch, parotidectomy on the left with defect removal using anterolateral thigh flap was performed. per histological examination, basal cell carcinoma with lymphovascular and perineural invasion and advancement into the masticator muscle and zygomatic bone was diagnosed, as well as carcinoma metastases in 2 lymph nodes with advancement beyond the capsule.

Conclusion. Implementation of revascularization flaps significantly widens choices for surgical treatment of this patient group in a regional oncological dispensary and gives satisfactory esthetic results due to removal of large defects after surgical intervention.

About the Authors

N. A. Sharafutdinova
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan
Russian Federation

Natalia Anatolyevna Sharafutdinova 

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan



Sh. I. Musin
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan; Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan

3 Lenin St., Ufa 450008, Republic of Bashkortostan



A. V. Sultanbayev
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan



K. V. Menshikov
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan; Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan

3 Lenin St., Ufa 450008, Republic of Bashkortostan



V. V. Ilyin
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan



B. A. Ibragimov
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan



A. A. Izmailov
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan; Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan

3 Lenin St., Ufa 450008, Republic of Bashkortostan



I. A. Sharifgaliev
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan



F. D. Zainullin
Republican Clinical Oncological Dispensary, Ministry of Health of Republic of Bashkortostan
Russian Federation

73 / 1 Prospekt Oktyabrya, Ufa 450054, Republic of Bashkortostan



References

1. The state of oncological care to the population of Russia in 2020. Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow: P.A. Herzen Moscow State Medical Research Institute – branch of the Federal State Budgetary Institution “NMIC of Radiology” of the Ministry of Health of Russia, 2021. (In Russ.).

2. Basal cell and squamous cell skin cancer. Clinical recommendations of the Ministry of Health of Russia. 2020.(In Russ.). Available at: https://oncology-association.ru/wp-content/uploads/2020/09/rakkozhi-bazalnokletochnyj-i-ploskokletochnyj.pdf.

3. Skoda A.M., Simovic D., Karin V. et al. The role of the Hedgehog signaling pathway in cancer: a comprehensive review. Bosn J Basic Med Sci 2018;18(1):8–20. DOI: 10.17305/bjbms.2018.2756

4. Snarskaya E.S., Poluboyarov A.A. Molecular mechanisms of development of basal cell carcinoma associated with hereditary syndromes. Rossijskij zhurnal kozhnyh i venericheskih boleznej = Russian Journal of Skin and Venereal Diseases 2014;3:4–8. (In Russ.).

5. Walling H.W., Fosko S.W., Geraminejad P.A. et al. Aggressive basal cell carcinoma: presentation, pathogenesis, and management. Cancer Metastasis Rev 2004;23(3–4):389–402. DOI: 10.1023/B:CANC.0000031775.04618.30

6. Musin Sh. I., Sharafutdinova N.A., Sultanbaev A.V. et al. Hedgehog inhibitor in the treatment of basal cell skin cancer: case report. Opukholi golovy i shei = Head and Neck Tumors 2021;11(1):109–14. (In Russ.). DOI: 10.17650/2222-1468-2021-11-1-109-114

7. Tanese K. Diagnosis and management of basal cell carcinoma. Curr Treat Options Oncol 2019;20(2):13. DOI: 10.1007/s11864-019-0610-0

8. Reshetov I.V., Matorin O.V., Babaskina N.V. Clinical characteristics and possibilities of drug therapy of inoperable locally advanced and metastatic basal cell skin cancer. Onkologiya. Zhurnal im. P.A. Gercena = Oncology. Journal named after P.A. Herzen. 2014;3(2):44–8. (In Russ.).

9. Бройнингер X., Белова И.А. Микроскопически контролируемая хирургия с трехмерным гистологическим контролем, тумесцентная локальная анестезия и внутрикожная шовная техника под натяжением в лечении злокачественных новообразований кожи. Опухоли головы и шеи 2018;8(3):21–36. DOI: 10.17650/2222-1468-2018-8-3-21-36

10. Niazi Z.B., Lamberti B.G. Perineural infiltration in basal cell carcinoma. Br J Plast Surg 1993;46(2):156–7. DOI: 10.1016/0007-1226(93)90150-a

11. Brown C.I., Perry A.E. Incidence of perineural invasion in histologically aggressive types of basal cell carcinoma. Am J Dermatopathol 2000;22(2):123–5. DOI: 10.1097/00000372-200004000-00006

12. Leibovitch I., McNab A., Sullivan T. et al. Orbital invasion by periocular basal cell carcinoma. Ophthalmology 2005;112(4):717– 23. DOI: 10.1016/j.ophtha.2004.11.036

13. Ratner D., Bagiella E. The efficacy of curettage in delineating margins of basal cell carcinoma before Mohs micrographiс surgery. Dermatol Surg 2004;30(5):821–2. DOI: 10.1046/j.1524-4725.2003.29272.x

14. Von Domarus H., Stevens P.J. Metastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literature. J Am Acad Dermatol 1984;10(6):1043–60. DOI: 10.1016/s01909622(84)80334-5


Review

For citations:


Sharafutdinova N.A., Musin Sh.I., Sultanbayev A.V., Menshikov K.V., Ilyin V.V., Ibragimov B.A., Izmailov A.A., Sharifgaliev I.A., Zainullin F.D. Clinical case of surgical treatment of advanced basal cell carcinoma of the skin on the face. Head and Neck Tumors (HNT). 2022;12(3):141-148. (In Russ.) https://doi.org/10.17650/2222-1468-2022-12-3-141-148

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ISSN 2222-1468 (Print)
ISSN 2411-4634 (Online)