Treatment strategies of recurrent jaw osteosarcoma: case report
https://doi.org/10.17650/2222-1468-2023-13-3-89-97
Abstract
Osteosarcoma of jaw is a rare malignant neoplasm of the maxillofacial region. Morphologically and radiologically identical to trunk and extremities sarcomas, but clinical features and prognosis of the disease have important differences. The strategy in treatment of gnathic sarcomas extrapolated from peripheral sarcomas, and represents an integrated multidisciplinary approach. The role of neoadjuvant chemotherapy remains controversial as well as adjuvant chemotherapy due to lack of clinical research. Surgical treatment with achievement of clean resection margins is the main favorable prognostic factor. Fibular free flap has been widely used for the last decade for mandible reconstruction. The strategies of treatment recurrent disease directly depend on ability to perform complete resection. Despite increased technical complexity, secondary free peroneal flap reconstruction can be performed safely, reliably, and with similar results to the premier segmental mandibulectomy. The use of radiation therapy is limited to unresectable or recurrent lesions. Well known that jaw osteosarcomas have a relatively higher survival rate and low metastasis rate, however, local recurrences significantly worsen the prognosis of patients. The following is a clinical case of treatment recurrent jaw osteosarcoma using second fibular free flap.
About the Authors
O. A. Saprina
N.N. Blokhin National Medical Russian Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Oksana A. Saprina
24 Kashirskoye Shosse, Moscow 115522
M. A. Kropotov
N.N. Blokhin National Medical Russian Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoye Shosse, Moscow 115522
B. B. Vyzhigina
N.N. Blokhin National Medical Russian Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoye Shosse, Moscow 115522
K. А. Ganina
N.N. Blokhin National Medical Russian Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoye Shosse, Moscow 115522
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Review
For citations:
Saprina O.A., Kropotov M.A., Vyzhigina B.B., Ganina K.А. Treatment strategies of recurrent jaw osteosarcoma: case report. Head and Neck Tumors (HNT). 2023;13(3):89-97. (In Russ.) https://doi.org/10.17650/2222-1468-2023-13-3-89-97
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