TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES

Objective: in paper direct results of investigation the products of tumor makers – CEA (carcino-embryonic antigen), CYFRA 21-1 and SCC and heat shock proteins hsp27, hsp70, hsp90. reflacting the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis.

Materials and methods. There were investigated 36 patients with chronic hyperplastic laryngitis. It was investigated the production of CEA (carcino-embryonic antigen), CYFRA 21-1, SCC and heat shock proteins hsp27, hsp70 in immune-enzyme method. The variation of serum concentration oncomarkers was investigated in dependent on the maximum production of heat shock proteins reflactihg the value of cell stress in chronic hyperplastic laryngitis. Statistics analysis was convey in programs Statistica (version 6,0) and “Biostat 4.03”.

Results. It was shown more prognostic informative in chronic hyperplastic laryngitis the level of CEA, CYFRA 21-1 and SCC on the background of maximum production of heat shock proteins hsp27, hsp70, hsp90. The serum level of CEA was higher in comparison with control. On the maximum of production hsp27, hsp70, hsp90 the concentration of CEA was 2–3 ng/ml, Cyfra 21-1 – 0–1,2 ng/ml and SCC 1–2 ng/ml. Conclusions. Variation of serum oncomarkers level of CEA – 2–3 ng/ml, CYFRA 21-1 – 0–1,2  ng/ml and SCC – 1–2 ng/ml are the prognostic value in the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis. This results is important in clinical practice.

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