Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report
Yu. M. Bychkov,
A. M. Mudunov,
I. M. Gelfand,
B. G. Pkheshkhova,
O. D. Ryzhova,
А. A. Akhundov,
V. Z. Dobrokhotova,
М. N. Narimanov https://doi.org/10.17650/2222-1468-2019-9-2-99-104
Abstract
The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.
Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.
Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.
Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy.
About the Authors
Yu. M. Bychkov
Russian Scientific Center of Roentgenoradiology, Ministry of Health of Russia
Russian Federation
Russian Federation
86 Profsoyuznaya St., Moscow 117997
A. M. Mudunov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
I. M. Gelfand
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
B. G. Pkheshkhova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
O. D. Ryzhova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
А. A. Akhundov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
V. Z. Dobrokhotova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Bld. 4, 2 Bol’shaya Pirogovskaya St., Moscow 119991
М. N. Narimanov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
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For citations:
Bychkov Yu.M., Mudunov A.M., Gelfand I.M., Pkheshkhova B.G., Ryzhova O.D., Akhundov А.A., Dobrokhotova V.Z., Narimanov М.N. Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report. Head and Neck Tumors (HNT). 2019;9(2):99-104. (In Russ.) https://doi.org/10.17650/2222-1468-2019-9-2-99-104
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