Diffuse midline glioma of the brainstem: genetic features, complications and treatment prospects
A. M. Kryanev,
I. D. Rozanov,
S. S. Lebedev,
D. N. Grekov,
K. S. Titov,
T. A. Yakusheva,
M. Kh. Salpagarov https://doi.org/10.17650/2222-1468-2024-14-1-49-55
Abstract
Diffuse midline glioma of the brain is a rare but very aggressive and resistant glial tumor. This pathology is characterized by impossibility of radical surgical treatment, radioresistance, resistance to drug treatment, high morbidity in children, low quality of life of the patients, frequent complications in the form of neurologic deficit, and unfavorable prognosis. The absence of effective treatment scheme for diffuse midline glioma requires identification of other methods (oncolytic virus therapy, immunotherapy) but there is not enough data on this topic leading to the necessity of its further investigation.
About the Authors
A. M. Kryanev
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
5 2nd Botkinsky Proezd, Moscow 125284
I. D. Rozanov
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
Ivan D. Rozanov.
5 2nd Botkinsky Proezd, Moscow 125284
S. S. Lebedev
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
5 2nd Botkinsky Proezd, Moscow 125284; Bld. 1, 2 / 1 Barricadnaya St., Moscow 125993
D. N. Grekov
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation
Russian Federation
5 2nd Botkinsky Proezd, Moscow 125284; Bld. 1, 2 / 1 Barricadnaya St., Moscow 125993
K. S. Titov
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department; Peoples' Friendship University of Russia
Russian Federation
Russian Federation
5 2nd Botkinsky Proezd, Moscow 125284; 6 Miklukho-Maklaya St., Moscow 117198
T. A. Yakusheva
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department; Peoples' Friendship University of Russia
Russian Federation
Russian Federation
5 2nd Botkinsky Proezd, Moscow 125284; 6 Miklukho-Maklaya St., Moscow 117198
M. Kh. Salpagarov
S.P. Botkin City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
5 2nd Botkinsky Proezd, Moscow 125284
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Review
For citations:
Kryanev A.M., Rozanov I.D., Lebedev S.S., Grekov D.N., Titov K.S., Yakusheva T.A., Salpagarov M.Kh. Diffuse midline glioma of the brainstem: genetic features, complications and treatment prospects. Head and Neck Tumors (HNT). 2024;14(1):49-55. (In Russ.) https://doi.org/10.17650/2222-1468-2024-14-1-49-55
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